Liver

Cirrhosis and Related Liver Disorders The liver is the largest gland and second largest organ in the human body. It is also the only internal organ capable of regeneration following injury. Located in the abdominal cavity, this reddish brown organ is divided into lobes of different size and shape. The liver plays a critical role in metabolism, digestion, elimination, and detoxification, among other processes. This organ performs a surprisingly large number of functions that influence virtually

What is liver damage and what are the diseases that are associated with it? Liver is one of the organs in the body that is able to regenerate itself, especially in some cases like liver transplant. The liver can regenerate and make new hepatic cells. However, liver damage or liver failure is a serious condition that progresses over time. Where the liver will no longer able to regenerate. There are many diseases that are associated with liver failure. For example, Hepatitis B and C, cirrhosis and

Liver fibrosis is the typical end-stage, pathological process that follows chronic hepatitis C(CHC)viral infection or other disorders of the liver.[1] Fibrosis is a dynamic scarring process in which chronic inflammation stimulates production and accumulation of collagen and extracellular matrix proteins as described in other articles. [1, 2] Over time patients with CHC viral infection experience a remodelling of the total collagen content. This progressive remodelling causes liver fibrosis, which

Papaya Seeds as a Treatment for Liver Cirrhosis Liver cirrhosis is a disease, usually caused by excessive alcohol consumption over many years, wherein the liver shrinks and becomes hardened. In this state it is ineffective at removing toxins from the body, leading to a variety of serious health problems. Papaya seeds are often reported as an effective treatment for liver cirrhosis. One method is to grind up around five dried seeds in a pepper grinder, or crush up fresh ones in a mortar and pestle

• Liver function: • The liver is a large, meaty organ that sits on the right side of the belly. • The liver is the main site of metabolism for drugs and other exogenous compounds. • It regulates the composition of blood, including the amounts of sugar, protein, fat , and nutrients. • Hepatotoxicity: • Damage or injury to the liver caused by a drug, chemical or other agent. Symptoms vary depending on the degree of exposure and hence extent of the liver damage or injury. Mild liver damage may cause

Liver plays a central role in transforming and clearing chemicals and is consequently susceptible to the toxicity induced from these agents. Chemicals that cause liver injury are termed hepatotoxins, and more than 900 drugs have been implicated in causing liver injury and it is the most common reason for a drug to be withdrawn from the market. Chemicals often cause subclinical injury to liver which may be manifest by abnormal liver enzyme tests. Certain medicinal agents when taken in overdoses and

Liver structure: The liver consists of a wide array of cell types: hepatocytes are the main parenchymal cells comprising 80% of the total cell population. Furthermore, there are smaller populations of non-parenchymal cells such as liver sinusoidal endothelial cells (LSECs), resident hepatic macrophages (Kupffer cells), pericytes or hepatic stellate cells (HSCs) and liver progenitor cells (LPCs) (Malarkey et al 2005; Wallace et al 2008). The hepatocyte is a polyhedral epithelial cell approximately

The Liver is the body's largest gland, weighing about three to four pounds. It is located beneath the diaphragm in the right upper quadrant (RUQ) of the abdominal cavity. Without the liver, our bodies would be poisoned and unfit for us to do anything at all. It is a metabolically active organ responsible for many vital life functions. The primary functions of the liver are: Bile productions and excretion. Excretion of bilirubin, cholesterol, hormones, and drugs. Metabolism of fats, proteins

Targeted Liposomes for Liver Fibrosis: In Vivo Liposome Delivery of siRNA to Stellate Cells to Silence TGF-B1 and VEGF Expression Summary Over the last few decades, liver disease has become a growing burden in global health due to the limited efficacy of treatment and therapies for liver disease. One potential solution to the dilemma of curative treatment for liver disease is the emerging development and utilization of nanotechnology strategies for more effective liver disease diagnosis and therapy

Liver cirrhosis is a problem that can be caused by many liver diseases. It is a progressive disease itself, developing slowly over many years. It is characterized as scarring to the normal liver tissue which keeps this organ from working as it should and causes it to take on an abnormal structure. The diseases that lead to cirrhosis injure and kill liver cells. Scar tissue that has formed due to inflammation and repair, prevents the cells that have not died to properly replace the dead cells which