Microfluidics

through a channel proportional to it can be considered or defined as microfluidics technology. It uses small size of particles and flow characteristics of fluid such as laminar flow in microchannel to manipulate particle behavior [1]. This resulted in the significant advancement in the field of bio-medicine especially through the development and discovery of newer methods of analysis, which is certainly without a doubt due to microfluidic technology and science [2]. This technology provides significant

Instrumentation & Microcontrollers Case Study - Microfluidics ZHENG Weihao 201419390 30th April, 2015 Report Declaration of Originality Contents Introduction 1 Motivation and features for Microfluidic and Lab-on-a-chip 1 Physical background and principle of operation 2 Two examples of Microfluidics technology 4 Microfluidics technology combined with microcontrollers 4 Two commercially available systems of Microfluidics technology 4 Future development of Microfluidics technology 5 Conclusions 5 References

The earliest microfluidic devices were made mostly made from silicon since the technology for patterning silicon wafers had already been developed by the electronics industry for its usage in microelectronics and micro electro mechanical systems (MEMS). Silicon however has the following disadvantages: (1) It is not optically transparent in the wavelength range used for optical detection; (2) Its conductive properties make it unsuitable for applications that involve electro kinetic flow to transport

results because human cells can be used. Microdosing is the process of giving minimal amounts of a product/medicine to subjects to see if reaction occurs, this eliminates the possibility of a deadly allergic reaction but still gives accurate results. Microfluidic chips also known as “organs on a chip” contain samples of human tissue from different parts of the body, these are linked by microchannels which then a blood substitute is run through the channels to represent bodily functions. Computer models

ABSTRACT Microfluidics biochips are revolutionary devices in the field of clinical diagnostics, DNA analysis and molecular biology. Biochips involve various fields of science and engineering i.e., physics, chemistry, biochemistry, nanotechnology, fabrication technology and computer science. It uses small volume fluids on scale of micro to nano liter for automatically carrying out the reactions needed for some biochemical assays. In this report I have covered basic overview of biochips, kinds of biochips

Introduction Microfluidics has been studied over the past two decades. Since then several industries have adopted these technologies to improve their processes. This new technology helps to develop microstructures, where all chemical and physical parameters could be tested in a controlled environment at a much faster rate with fewer safety issues involved. The utility and the lifetime of microfluidic systems depend critically on their ability to maintain a flow without interruption. Indeed, clogging

ARTICLE MAKE A TITLE Qasid Chaudhry Human Biology Department, University of Toronto, Toronto, ON M5S 3J6 Microfluidic chips allow for the manipulation, at small quantities of neuronal cells. Further, these chips allow for precise temporal and spatial control. This model is one that can be useful in the framework of neurodegeneration. Deleglise et al (2013) fabricated a 3 chamber microfluidic chip. The chambers held one of: coritical neuron soma and dendrites, cortical axons, or striatal neurons.

involved in clinical and laboratory research for the last three years. I worked during the summer, and as I gained proficiency with the technology, I began working on these projects during the school year too. I worked on a project where we applied Microfluidic assay technology to assess the function of Calponin in platelets. This is a unique study that I completed under the guidance of my mentor Dr. Hines, who is an assistant professor at the Wayne State School of Medicine in Detroit, Michigan. As a

from various sites according to cancer type.1 The small sample volumes, real time detection, multiplexing capabilities inherent in microfluidic systems offer the opportunity for CTCs separation and detection.3 Most reported microfluidic devices for CTC detection are based on cell-affinity micro-chromatography, magnetic activated micro-cell sorting, size-based microfluidic separation, and dielectrophoresis.3 While the majority of existing systems focused on cell

5. Hydrogel Based Microreactors Hydrogels are water swollen three-dimensional polymer networks with utilities in diverse areas of biotechnology and biomedicine, tissue engineering.[216] These materials have significant advantages over solid matrices comprised of water-insoluble organic polymers.[217] In that a well-hydrated environment provides stability and function of immobilized biological cargo, including enzymes and cells.[218] A wide choice of constituting polymers, both natural and synthetic