Myelin

1.6 Role of AGC1 in the myelin synthesis One of the main symptoms of the patients affected by AGC1 deficiency, i.e. the cerebral atrophy with global brain hypomyelination suggests that the blocked efflux of aspartate from neuronal mitochondria, due to the impaired AGC1, can alter the normal myelin formation (Falk et al., 2014; Wibom et al., 2009; Wolf & van der Knaap, 2009). The cytosolic aspartate is essential for many synthetic processes as that of urea, purines, pyrimidines and proteins. In neurons

This report will discuss what multiple sclerosis is, symptoms, how it is treated, and much more. Multiple Sclerosis causes demyelination and affects the central nervous system. Multiple Sclerosis is caused by chromosome 6. It is an autoimmune disease in which the body’s immune system attacks its own tissues. Symptoms of this disorder include numbness or weakness in one or more limbs typically on one side of the body or the legs, partial or complete loss of vision, tingling or pain in parts of

Gangliosides (GM) are glycosphingolipids with complex structures that are found within cellular membranes. They are most abundant in the nervous system with many important functions such as serving as the structural components of biomembranes, mediators in signal transductions, and playing a role in cell-to-cell recognition. While the presence of gangliosides is vital to cellular function, ganglisoide degradation is necessary to prevent a buildup of lipids. The excess presence of gangliosides

ASHA defines dysarthria as “A neurological motor speech disorder affecting the strength, range of motion, speed, and precision of the speech musculature” (ASHA, 2017). There are several congenital and acquired causes for this disorder including: traumatic brain injury, tumors, degenerative diseases, strokes, toxic and metabolic conditions. The damage causes paralysis, weakness, or lack of coordination of the the muscles involved in articulating speech, which results in reduced intelligibility. Dysarthria

“Stay Down! Stay Down! Nice little mouse,” Doctor Goldman said wearily as he stumbled to the floor. “NO! NO!,” he shouted and then it went silent. The whole experiment started off to show how human glial cell transplants could help cure diseases like alzheimer's and multiple sclerosis.Glial cells make up over eighty percent of the brain cells with neurons making up the roughly other twenty percent. The glial cells are responsible for guarding and protecting the neurons. The hope was that because

Multiple Sclerosis is also known as MS and is a disease of the central nervous system. It is a chronic inflammation disease that is immune-mediated and attacks the protective sheath that covers the fibers of the nerve and causes problems of communication between the brain and the remainder of the body. This disease will eventually cause the nerves to deteriorate or become damaged permanently. Multiple Sclerosis has the potential to disable the brain and spinal cord. The cause of this autoimmune disease

Cristiaan Ciarlo Bio 328 Summary: The article titled: Microbiota Controls the Homeostasis of Glial Cells in the Gut Lamina Propria assessed the varying conditions in which Microbiota within the developing digestive tract can influence the process of network formation of the certain aspects of the enteric nervous system. The enteric nervous system (ENS) is the aspect of the digestive system endowed with its own nervous system (Bowen 2006). As far as the article is concerned, there were three

There are many people worldwide who are being diagnosed with musculoskeletal disorders daily. Spinal Stenosis is a perfect example in which many adults over the age of 60 Years of age develop. This is a disease that causes a narrowing in the spinal canal which can lead to added pressure on the spinal cord and the nerves that travel through the spine (Mayo Clinic, 2015) Spinal stenosis is most commonly found in 2 places of the spine. If the upper portion of the spine is affected, it is referred

Psoriasis is a chronic immune- mediated skin disease which affects adult population. It has the symptoms which includes redness, scaling, flaking, pruritus, skin tightness, pain, and bleeding. It has significant negative impact on patients’ physical and mental functioning. This disease also leads to impairment of quality of life, psychological well-being, and work productivity. Brodalumab is a human monoclonal antibody which blocks IL-17 receptor. There are three clinical trial phase were done by

Abstract Myelin and oligodendrocyte dysfunctions have been consistently found in patients with schizophrenia. The effect of antipsychotics on myelin disturbances is unknown. The present study examined the effects of quetiapine on oligodendrocyte regeneration and myelin repair in a demyelination animal model. C57BL/6 mice were fed with cuprizone (0.2% w/w) for 12 weeks to induce chronic demyelination and oligodendrocyte degeneration, after which cuprizone was withdrawn to allow recovery. Quetiapine