Oligodendrocyte

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  • Oligodendrocytes Essay

    1294 Words  | 6 Pages

    AdilijiangbLyndaKongbJunhuiWangbJimingKongcQingrongTanaXin-MinLiabc Show more https://doi.org/10.1016/j.brainres.2012.06.003Get rights and content Abstract Increasing evidence supports an important role of oligodendrocytes and myelination in the pathogenesis of schizophrenia. Oligodendrocytes are the myelin-producing cells in the central nervous system. To test the myelination dysfunction hypothesis of schizophrenia, possible myelination dysfunction was evaluated in a phencyclidine (PCP)-induced

  • Essay On Oligodendrocytes

    1277 Words  | 6 Pages

    As aforementioned, due to high metabolic demands, oligodendrocytes are specifically vulnerable to oxidative stress in the mitochondria, as well as ER stress. A prominent example is the cuprizone animal model, which uses cuprizone as a oligodendrocytes-specific neurotoxin that induces CNS demyelination in mice, specifically in the corpus callosum (Torkildsen, Brunborg, Myhr, & Bo, 2008). Importantly, cuprizone acts as a chopper chelator that interferes with complex IV of the mitochondrial respiratory

  • Cuprizone Lab Study

    4820 Words  | 20 Pages

    Differential effects of antipsychotics on the development of rat oligodendrocyte precursor cells exposed to cuprizone Abstract Cuprizone (CPZ) is a copper-chelating agent and has been shown to induce white matter damage in mice and rats. The compromised white matter and oligodendrocytes (OLs) respond to some antipsychotics in vivo. However, little is known about the effects of antipsychotics on cultured OLs in the presence of CPZ. The aim of this study was to examine effects of some antipsychotics

  • The Effects Of Myelin And Oligodendrocyte Dysfunctions

    5738 Words  | 23 Pages

    Abstract Myelin and oligodendrocyte dysfunctions have been consistently found in patients with schizophrenia. The effect of antipsychotics on myelin disturbances is unknown. The present study examined the effects of quetiapine on oligodendrocyte regeneration and myelin repair in a demyelination animal model. C57BL/6 mice were fed with cuprizone (0.2% w/w) for 12 weeks to induce chronic demyelination and oligodendrocyte degeneration, after which cuprizone was withdrawn to allow recovery. Quetiapine

  • Attempts to Mobilize Oligodendrocyte Progenitors Essay

    518 Words  | 3 Pages

    The lineage of rodent oligodendrocyte has been very well characterized in vitro studies. In fact, the oligodendrocyte formation is very crucial in embryogenesis as well as in the postnatal development of the individual. To be more specific, these cells are essential for myelinating neuronal axons in the central nervous system and thus allowing fast conduction of electric impulses along the neurve fibres. Oligodendrocyte death leads to demyelination process, a pathological feature of neurological

  • Aspirin: The Miracle Drug Essay

    1158 Words  | 5 Pages

    may result in cognitive impairments such as deficits in learning and memory. White matter lesions (WML) have also been linked to increasing the risk of post-stroke dementia. Cerebral white matter damage has been widely overlooked. Comprised of oligodendrocytes that form the insulating myelin in the CNS, white matter is evidentially just as vulnerable to ischemia as gray matter.

  • Complications Of Antiterase On The Development Of CG4 Cells

    3896 Words  | 16 Pages

    igodendrocyteÊlineageÊtranscriptionÊfactorsÊ1ÊandÊ2. Abstract Aims Oligodendrocyte/myelin abnormalities may be an important component of the pathogenesis found in schizophrenia. The aim of this current study was to examine the possible effects of the antipsychotic drugs (APDs) haloperidol (HAL), olanzapine (OLA), and quetiapine (QUE) on the development of oligodendroglial lineage cells. Main methods CG4 cells, an oligodendrocyte progenitor cell line, were treated with various concentrations of HAL

  • The Spinal Cord and Spinal Cord Injury

    1139 Words  | 5 Pages

    However, studies have shown that human embryonic stem cell derived oligodendrocyte progenitor cells can help in neuroprotection, homeostatic maintenance, suppressing inflammation, and promoting the regeneration of axons. (Sharp et al., 2010). Most of the neural stem cell potential is in ependymal cells (Meletis et al., 2008). Transplanting these oligodendrocyte progenitor cells just one week after the injury showed widespread oligodendrocyte remyelination throughout the white matter (Keirstead et al.

  • What Is Myelin Gene Regulatory Factor ( MRF )?

    1636 Words  | 7 Pages

    expression is specific to terminally differentiated oligodendrocytes (Cahoy et al., 2008; Heiman et al., 2008). Importantly, knockdown of MRF in oligodendrocytes by RNA interference downregulates expression of the majority CNS myelin genes (Emery et al., 2009). In contrast, overexpression of MRF in in vitro cultured OPCs can promote myelin gene expression. Oligodendrocyte lineage-specific MRF knockout mice show normal premyelinating oligodendrocytes but they display severe myelin gene expression deficits

  • A Diet Of Fasting And Its Effects On Children

    1804 Words  | 8 Pages

    A diet mimicking fasting alleviates MS symptoms – the ‘fast’ way to reduce the effects of autoimmunity. A discussion of the article ‘A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms’ which was published in June 2016, by In Young Choi, Laura Piccio, Patra Childress, Friedemann Paul, Markus Bock, Valter D. Longo Abstract Choi et al. have found that participating in a diet mimicking fasting can promote regeneration of myelin and reduce autoimmunity

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