Oligomer

phase. A few G-actin subunits combine to form short oligomers. However these are unstable and readily dissociate. When three subunits bind together and transition to form a more stable oligomer with many subunit-subunit interactions, this can then act as a seed for actin polymerisation (often called the nucleus). The phase is sometimes referred to as the lagging phase, this is due to a delay in the time taken for G-actin to form these stable oligomers. This was proven in experiment when some preformed

concentration. We speculated a possible structural rearrangement of A fibers (disintegration) occur after binding to nanodiscs resulting in the ThT quenching during the reaction due to an inherent nature of off pathway unstable protofibers and/or oligomers. Rapid sheet induction in A1-40 by Nanodiscs The secondary structural transition of A1-40 form a random coil conformation to a metastable sheet structure during self-seeding reaction is a ubiquitous phenomenon. Here, we investigated the

Fortunately this method had better results though there are a lot more things to overcome. In making PNA a prospect for drugs, researchers have demonstrated proof of concept for using PNA oligomers to activated or suppress the transcription, replication, or repair of specific genes by binding DNA is various ways. PNA oligomers and conventional nucleic acids have the same problem of poor bioavailability because they are large water loving molecules making it difficult for them to enter cells. The productions

using chitosan and its derivatives” (Advanced Drug delivery reviews, 2010). Second, critique an original research paper about hydrotropic oligomer-conjugated glycol chitosan as a carrier for tumor-targeted paclitaxel delivery, which was published in Journal of Controlled Release in 2013 (title: Enhanced drug-loading and therapeutic efficacy of hydrotropic oligomer-conjugated glycol chitosan nanoparticles for tumor-targeted paclitaxel delivery). Chitosan, a linear aminopolysaccharide composed of randomly

#1 Make Observation What causes Alzheimer’s disease neurologically? This question came to my mind when I was watching the movie ‘The Notebook’ for the fifth time. Unusual for a guy, I love romantic genre movies and I was wondering why Alzheimer causes short and long term memory loss. I also had an interest on the Alzheimer’s disease after watching the movie ‘Rise of the Planet of the Apes’ where the protagonist tries to fix the neurology nerve system to heal his father’s Alzheimer. #2 Ask Question

Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most widespread age-related neurodegenerative diseases. Both diseases impact a considerable number of people, where AD occurs in around 10 percent of the population greater than the age of 65 while PD occurs in roughly 1 percent of the population above the age of 65. AD is considered to be the most widespread cause of dementia, characterised by the progressive memory and cognitive deficits which impair ones day to day activities. The pathological

to generate an immunotherapy that targeted the modified ATXN1 oligomers. After injecting the infected mice with the immunotherapy the research group observed a hindrance of local propagation of the oligomer and therefore modified the phenotype of the prion positive mice. However this method is not curative, as the neurons that express the poly-Q ATXIN1 oligomer will continue to do so, generating more toxic prion like proteins. This provided cause for the theory that though the immunotherapy may

Alzheimer’s is a progressive neurodegenerative disease that steadily destroys the memory and other important mental functions such as social skills, intellect, and memory (4). Although the exact cause of Alzheimer’s is not known, most cases of the disease are caused by genetic mutations passed from the parent to the child (1). There are several genes associated with Alzheimer’s one in particular is apolipoprotein E (1). The presence of one or more of these genes does not necessarily mean that

sHSPs are a ubiquitous class of chaperones found across all kingdoms of life. sHSP range in size from 12-42 kilo Daltons in large oligomers of 12 to >32 subunits and the structure is homologous across all species. The sHSP monomer consists of three domains: a disordered N-terminal arm, a beta-sandwich α-crystallin domain, and a flexible C-terminal extension. The N-terminal domain is

Autophagy is an essential mechanism for maintaining cellular homeostasis. Scattered evidence suggests the involvement of autophagy in the maintenance of stemness by preventing senescence. However, further studies are required to confirm the specific effects and mechanism of autophagy on NSC population. Therefore, in the current proposal, we hypothesize that autophagy may profoundly affect NSC pool, early stage neuronal development and functional stability of neural circuits in the neurogenic regions