P53

A cancerous cell must adapt to various biological, chemical pathways, and modify it to impose its malignant behavior in human’s cell. The authors, Douglas Hanahan and Robert A. Weinberg points out six significant variations in cell physiology that leads to the composition of most of these cancerous cell. The cell’s autonomy in growth signals, insensivity to growth-inhibitory signals, circumvent apoptosis, endless replication, angiogenesis sustainability, as well as neighboring tissue invasion along

SLE is an autoimmune disease that is more common in women versus men. Ninety-six percent of SLE cases are in women, whereas only four percent of SLE cases occur in men. The survival rate of systemic lupus erythematosus has improved due to many factors such as earlier diagnosis, better management of disease and prevention of organ damage. Despite these advances in care, the life expectancy of patients with SLE remains, lower than the general population. SLE may also be associated with an increased

Kerr, Wyllie, and Currie first used the term apoptosis in a paper in 1972 to describe a morphologically distinct form of cell death, although certain components of the apoptosis concept had been described years previously. Our understanding of the mechanisms involved in the process of apoptosis in mammalian cells transpired from the investigation of programmed cell death that occurs during the development of the nematode Caenorhabditis elegans (Horvitz, 1999). In this organism 1090 somatic cells

JCV belongs to the Polyomaviridae family comprising non-enveloped tumor viruses with icosahedral capsids containing small, circular, double-stranded DNA genomes [White et al., 2005]; it encloses a large number of members that are able to infect various animal species including rodents, rabbits, birds and primates, including man [Imperiale, 2001; Delbue et al., 2012]; in particular, to date, have been discovered 11 polyomaviruses infecting man [White et al., 2013; Feltkamp et al., 2013] (Fig. 1.1)

DISCUSSION Here we report that TRF2 transcriptionally regulates p21 expression. Our results show that this is through the engagement of the REST-CoREST-LSD1 repressor complex at the p21 promoter in a TRF2-dependent fashion. To the best or our knowledge this has not been reported before. Co-immunoprecipitation experiments showing interaction of TRF2 with the histone modification factor lysine-specific demethylase LSD1 inside cells, and interaction of TRF2 with REST further supported role of TRF2

Heme-group containing mammalian peroxidase enzymes possess a highly conserved structure and partake in reactions associated with the development of inflammatory diseases, defense system of the host as well as the biogenesis of hormones (Péterfi et al., 2009)(Cheng, Salerno, Cao, Pagano, & Lambeth, 2008). The heme-binding sites of peroxidase enzymes possess specific features that are preserved as well as characteristics including disulphide bonds forming between cysteine residues, a binding site for

Ovarian cancer is one of the leading cause feminine death. Ovarian cancer is cancer that is located in the female organ that produces eggs. Ovarian cancer is most likely to develop in the females that have lived half a century or more. Ovarian cancer cannot be discovered until it has reached the pelvis area in certain tests. Once it has actually reached the pelvis area, it is considered fatal and this is considered the last stage. There are three types of ovarian cancer: epithelial, stromal, and

A cancerous cell must adapt to various biological chemical pathways and modify itself to impose its malignant behavior not only in humans but as well as in other species. The authors, Douglas Hanahan and Robert A. Weinberg points out six significant variations in cell physiology that leads to the composition of most of these cancerous cell. The cell autonomy in growth signals, insensivity to growth-inhibitory signals, avoid apoptosis, endless replication, angiogenesis sustainability, as well as neighboring

Multiple Myeloma Multiple Myeloma is a form of cancer which affects the plasma cells of the body, which are white blood cells. Multiple Myeloma, first described in 1848, is a disease “characterized by a proliferation of malignant plasma cells and a subsequent overabundance of monoclonal paraprotein.” To understand how Multiple Myeloma affects an infected person’s plasma cells, it helps to have a general understanding of how normal blood cells are formed and how they act. Most blood cells develop

The Onyx-015 is an oncolytic adenovirus that is similar to the H101 virus. The Onyx-015 is also used to treat head and neck cancers along with chemotherapy. This virus has been created in the US but has yet to be regulated by the government. During the trial period of the virus, there were 22 patients admitted into the trial that had head and neck cancers. In order to be admitted into the trial there were some conditions that had to be met. These conditions consists of, the life expectancy of the