Paclitaxel

The development of taxol and docetaxel into two of the worlds most important anticancer drugs (Taxol® and Taxotere®) has proven the stabilization of cellular microtubules to be a clinically relevant mechanistic principle. Microtubule stabilization thus also provides a promising conceptual framework for the future discovery of new and improved antitumor agents and this is not in the least reflected in the significant number of new agents (taxane and non-taxane based) that are currently undergoing

Researchers at the National Cancer Institute have found that approximately 38.5% of both male and female will be diagnosed with some form of cancer throughout their lives. Unfortunately, this statistic hits a little too close to home for many of us. (BE3) Because there are so many different branches, forms, and strings of cancer, scientists are still unable to find a specific cure for all of them. (BE2) Cancer affects all of us in so many different ways and with so many different people, for me,

HINTS is an acronym for Health Information National Trends Survey and its purpose is to collect cancer-related data on a national level (HINTS, 2007). The goal of HINTS is to assess how information pertaining to cancer is accessed, how the risk of developing cancer is viewed by the public, how the course of communication has changed, and how the patterns of health has changed through the course of the past several years (HINTS, 2007). Once data has been collected, researchers are able to gain a better

What is Docetaxel Docetaxel (doe-se-TAKS-sel) is a man-made antineoplastic chemotherapeutic agent developed to treat different types of cancers by stop cancer cell replication. Antimicrotubule agents such as docetaxel inhibit the microtubule structure of the cell ultimately results in the cells death. Microtubules are part of the cell's machinery for dividing and replicating itself. Belonging to the taxoid family Docetaxel is an antineoplastic. Also known as Taxotere its original trademarked brand

According to the National Cancer Institute and other cancer organizations, there are about 250000 to 400000 people who receive chemotherapy each year. Medical professionals knows enough about the side effects that these drugs pose an acceptable amount of risk in relation to the benefits that they offer. Health care professionals do ways to prevent, detect and diagnose, control, and treat the cancer through studying the psychological impacts of the disease and its treatment and the ways to improve

Following an acute hypersensitivity reaction and return to baseline, the paclitaxel titration regimen was initiated. Paclitaxel is mixed in 250 mL NS or D5W for weekly doses, and in 500 mL NS or D5W for every 3 weekly doses. Titration rate for rechallenge paclitaxel infusions is as follows: 30 mL/hour = 5 mL; 60 mL/hour = 10 mL; 90 mL/hour = 15

INTRODUCTION What are lung cancers? Lung cancers are the abnormal cells which grow in uncontrolled manner in one or both lungs. They do not function as normal lung cells and do not develop into healthy lung tissue. The abnormal cells can grow, form tumours and interfere with the normal functions of the lung (Lungcancer.org, 2015). Lung cancers can be divided into two major types, namely non-small cell lung cancers (NSCLC) and small cell lung cancers (SCLC). NSCLC can be further classified into three

Literature Review Draft Atherosclerosis is characterised by gradual decrease in the luminal diameter of large arteries, it has major health implications and contributes to around 50% of all deaths within westernized countries (7). Patients can undergo coronary artery stenting to prolong the effects of this. Treatments for this have undergone major developments over the past 40 years, including balloon angioplasty in 1977, development of bare-metal stents (BMS) in the 1980’s, introduction of drug-eluting

transporter. In the article, Sharma and Freeze believe paclitaxel should stabilize and reverse the inhibitory effect of nocodazole, however this is not the case. Paclitaxel binds to tubulin and inhibits the disassembly of microtubules, thereby likewise inhibiting cell division. It also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor. It was found in Figure 4b. the presence of both nocodazole and paclitaxel the movement of compounds by mannose is less than when

Cancer Cancer is one of the leading causes of morbidity and mortality worldwide, with approximately 14 million new cases in 2012.2 The amount of new cases is expected to rise by about 70% over the next 2 decades. Cancer which causes nearly 1 in 6 deaths, is the second leading cause of death globally, and was responsible for 8.8 million deaths in 2015. Approximately 70% of deaths from cancer occur in low- and middle-income countries. In 2012 about 14.1 million new cases of cancer occurred globally