Pluripotency

Our entire bodies are made up of cells; without them, our bodies would not be able to thrive, let alone be created. Our bones, muscles, organs, tissues and skin are all composed of specialized cells that code for the type of cell they are assigned to be. Many body cells, for example, a liver cell, can reproduce many new cells; but the cells reproduced are only capable of being created as a liver cell. This example is a major reason why researchers are so interested in stem cell research. Stem cells

Injection Therapy using Stem Cells Imagine a future where Alzheimer’s and Parkinson’s diseases are looked at in the same regard as polio. Imagine a different and truly personal kind of medicine that avoids the use of potentially risky and invasive procedures. Regenerative medicine has the promise to be just that. Using injection therapy which involve the injection of stem cells which undergo differentiation that will repair damaged tissues. This process happens when one parent (stem) cell divides

The Great Stem Cell Debate In 1998, President Bill Clinton issued a National Bioethics Advisory Commission to begin to study the question of stem cell research (Stem Cells Fast Facts). Since then many advances have been made and stem cells have been used to aid in the alleviation of several medical conditions such as macular degeneration, bone marrow deficiencies, and growing new sheets of new skin for burn victims (Hug). Even though there is much stigma surrounding stem cell research, the medical

This state of pluripotency means that these cells can be used to replace old damaged tissues or help rebuild destroyed parts of the body. However the reason these cells are so controversial regardless of their highly flexible use and compatibility is “ because when scientists

self-replicate all cell types in an adult organism, it facilitates genetic manipulation and improves cloning efficiency by nuclear transplantation. This article also demonstrates many reports for long-term capacity for proliferation and in vivo pluripotency. Despite the focus being more on examples and tests on livestock genetic engineering, this article still provides valuable information to understand the different and possible methods for genome editing. So, while it doesn’t appeal to what the

The question of this article is to determine if skin dermal papilla (DP) cells can differentiate into induced pluripotent stem cells (iPSCs) by using the transcription factor, OCT4, instead of using all four transcription factor, OCT4, Sox2, Klf4, and c-Myc, which are usually used to differentiate somatic cells into stem cells. The scientists came up with the question because two out of the four transcription factors, Klf4 and c-Myc, are oncogenic gene, thereby it is best to replace these genes

Because these cells are pluripotent, meaning they are able to differentiate into all cell types in the body, they are extremely malleable making them a scientific marvel worth researching. This state of pluripotency means that these cells can be used to replace old damaged tissues or help rebuild destroyed parts of the body. However, the reason the use of these cells is so controversial, regardless of their high level of flexibility, functionality, and compatibility

JAK2/STAT signaling pathway was one of the most significantly differentially expressed gene sets in BC compared with CP progenitors. This signaling pathway increases the ADAR1 expression in progenitor LSCs and promotes ADAR1-mediated A-to-I editing. Furthermore, ADAR1 impairs biogenesis of tumour suppressive miRNAs, thereby contributing to cancer progression. Since the let-7 miRNA family is also related to self renewal of LSC, it led the authors to investigate the correlation between JAK2/STAT

improve patient’s quality of life, yet the (cure. the invention of iPSC, provide opportunity) MORE! Establishment of iPSC The interest in developing human embryonic stem cells (hESCs) as a regenerative medicine has been prospering due to its pluripotency and indefinite self-renewal capacity since first discovered in 19981,2. However, the method to harvest hESCs by destroying embryos raised ethical concerns and thus the progress of this therapeutics has been impeded for years. Alternative approach

“Research Proposal” Medical Biotechnology, Health Sciences Honours Research Proposal 30/06/2015 John Drummond 2040768 1) Grant titles Scientific title Analysis of adipose derived induced pluripotent stem cells (iPSC’s) microRNA (miRNA) expression profile over multiple passages and pancreatic β-cell miRNA expression profile post differentiation from iPSC’s. Simplified title Improvement of stem cell differentiation to pancreatic β-cell for transplantation into diabetics. 2) Project