Pluripotency

Currently, there is a global increase in cases of bone disorders and conditions, which is expected to increase as twice as much by 2020 particularly in countries where obesity and poor physical activity are associated with aging[1]. Although reconstructive orthopaedic surgery can be used to treat bone defects and injuries caused by trauma, additional treatments are required for severe breaks or pathological conditions as well as critical bone defects due to malformation, cancer or osteoporosis in

Since the discovery of human embryonic stem cells, scientists have had high hopes for their use in treating a wider variety of diseases because they are “pluripotent,” which means they are capable of differentiating into one of many cell types in the body. However, the acquisition of human embryonic stem cells from an embryo can cause the destruction of the embryo, thus raising ethical concerns. In 2006, researchers introduced an alternative to harvesting embryonic stem cells called induced pluripotent

Induced pluripotent stem cells (also known as iPSCs) are a type of pluripotent stem cell that can be generated directly from adult cells. iPSCs are typically derived by introducing products of specific sets of pluripotency-associated genes, or "reprogramming factors", into a given cell type. 2. ISSUES Although the human cloning seems fairly beneficial and useful for human welfare, the possibility of human cloning has raised controversies. Concerning reproductive

For 70+ years now we have been working on our Epigenome but not really understood what it is or what it can do for us but, thanks to the works of Dr. Conrad H. Waddington “Epigenetic Landscape” 1939, which was followed up and expanded on by Dr. Adrian Bird and Danny Reinberg (1975~) we know that it does exist and it has far reaching implications for future development in medical research and biological development fields.  Risk assessment  Prevention  Progression analysis  Prognosis and biomarker

1.0 Introduction This report aims to investigate the different views held on the pros and cons of development in stem cell research. This report will provide background to the debate, its social significance, parties that are involved and analysis of the arguments related to the topic researched. 2.0 The Issue and background to the debate Those who favour stem cell research are optimistic about the continued developments in stem cell research will open doors to many breakthrough discoveries

iPSCs are typically derived by introducing products of specific sets of pluripotency-associated genes, or "reprogramming factors", into a given cell type. 2. ISSUES Although the human cloning seems fairly beneficial and useful for human welfare, the possibility of human cloning has raised controversies. Concerning reproductive

cells positioned in the early embryo” (Miller Ph.D., Levine Ph.D.). Pluripotent means that the cells are capable of developing into most of the body’s cell types and have the ability to aid and cure diseases. (Miller Ph.D., Levine Ph.D.). This pluripotency is what distinguishes between embryonic and adult stem cells. The embryonic stem cells can be generated in every cell type in the body and can indefinitely create themselves making it possible for tissue replacement in addition to finding cures

Genetic counseling is a newfound passion of mine fostered by my NIH research postbac position in Dr. Karen Usdin’s lab and volunteering as a crisis prevention & intervention hotline counselor. These are the experiences I have been able to procure on my path to graduate school to explore my interest in the scientific and psychological relationship needed to counsel individuals about genetic disease. It was after I was able to sit in and observe one of the Johns Hopkins/NHGRI genetic counseling seminar

When someone tears their ACL, their first thought goes to getting ACL surgery, or ACLR. However, there are non-surgical treatments for special populations. Those populations are young children and older individuals. Additionally, there are alternatives to ACLR. Children with tears in their ACL can be treated nonsurgically. Children can heal easily due to vascularization, or the formation of blood vessels, which plays a role in the healing process of the body. “An explanation for the discrepancy

Gsk-3 Regulates DNA Methylation Gsk-3 activity has been observed to regulate DNA methylation through altered expression of DNA methyltransferase Dnmt3a2. This was confirmed by knocking out both Gsk-3 isoforms (Gsk-3 DKO) in mouse ESCs, resulting in the reduction of DNA methylation and altered gene expression (Meredith et al., 2015; Popkie et al., 2010). Lithium mimics this reduced Gsk-3 activity in two ways: direct inhibition and indirect inhibition by increasing inhibitory phosphorylation of Gsk-3