Porphyrin

as biological importance in the human body. Porphyrins are an example of one of these compounds and it helps create many substances utilized by the body, like hemoglobin (National Library of Medicine, 2013). Porphyrin, when it is in its purified form, can be mixed with several metals to form metalloporphyrins, for example if magnesium s the metal mixed with the porphyrin it can create chlorophyll (Weldegirma, 2014). An important characteristic to porphyrin is that it is aromatic and this is determined

therapy agents, including others based around porphyrin, absorb between 650-850 nm, thus allowing for deeper penetration of activating radiation into tissues.4 According to a study by Wormald et al.,5 another 3 porphyrin-based compound, known commercially as verteporfin, also shows promise in the treatment of macular degeneration by selectively halting the growth of harmful blood vessels under the retina. The photochemical and optical properties of porphyrin compounds have also made them a target of

URO-synthase is an enzyme involved in the metabolism of the tetrapyrrole compound porphyrin, which composes heme. Heme performs a variety of biological functions but is most commonly known for being a component of hemoglobin, helping it to provide oxygen to tissues throughout the body. Specifically, URO-synthase functions to convert a linear

Hemoglobin can bind to four molecules of oxygen. When a hemoglobin molecule binds to oxygen molecules, the resulting molecule is referred to as oxygenated hemoglobin. Hemoglobin molecules that are not bound to any oxygen molecules are referred to as deoxygenated hemoglobin (Harvey, et al., 2011). Oxygenated hemoglobin is formed through the transportation of oxygen to cells in tissues. The binding of oxygen to hemoglobin is cooperative. This means that once an oxygen molecule is bound to an iron

the body. In particular, there is an insufficiency of the body to process porphyrins which are a metal-containing pigment. However, porphyria is actually a group of diseases with the commonality of the accumulation of porphyrins or porphyrin precursors. Porphyria is derived from the Greek word porphyrous meaning reddish-purple. Urine from patients display a reddish-purple hue due to the presence of excess amounts of porphyrins. This is a rare disease with the most common type porphyria cutanae tarda

Structure-based design and evaluation of synthetic porphyrin derivatives as G-quadruplex stabilizing anticancer agents R. N. Bhadanea*, D. B. Meshramb, R. M. Gilhotraa, R. R. BhadaneC aGyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jaipur, Rajasthan, India bPioneer Pharmacy Degree College, Sayajipura, Ajwa-Nimeta Road, Vadodara, Gujarat, India cLoknete Dr. J. D. Pawar College of Pharmacy, Manur, Tal-Kalwan, Dist-Nashik, Maharashtra, India G-quadruplex structures formed in telomeres

Complexation of porphyrin with the metal will cause the shifts of Q bands in the UV-Vis spectra in the range of 500-700 nm as shown in Figure 2.7. This can be observed by the disappearance of two Q bands out of four as the porphyrin undergoes the change from D4h symmetry to D2h symmetry (Rita Giovannetti, 2012). The Q-bands were denoted as α and β. The coordination of porphyrin to Ni(II), Sn(IV) or Pd(II) which can form stable square planar complexes generally consists of a higher α peak (Figure

photosensitizers are exposed to a certain wavelength of light, they produce a form of oxygen that kills nearby cells. Photodynamic Therapy is also a potential therapy for cancer treatment. Photosensitizers are generally classified as porphyrins or non porphyrins. First generation photosensitizers include hematoporphyrin derivative and Photofrin. A number of second generation photosensitizers have been developed to alleviate certain problems associated with first generation molecules such as prolonged

Supramolecular chemistry actually represents a fairly simple concept.“In contrast to molecular chemistry, which is predominantly based on the covalent bonding of the atoms, supramolecular chemistry is based up on intermolecular interactions, i.e on the association of two or more building blocks, which are held together by intermolecular forces”. When molecules get larger, they have the ability to stick together and that allows the formation of larger assemblies of molecules that are not bonded to

Catalase possesses a range of optimal temperatures depending on what organism those cells belong to. Human catalase has an optimum temperature of around 45 degrees Celsius, whereas plants have a slightly lower optimal temperature for catalase at around 37-40 degrees Celsius. Catalase works optimally at a neutral pH between 6.8-7.5, allowing it to operate in nearly all types of cells. Catalase is generally found in the peroxisomes of a cell, but can also be found elsewhere in small quantities. Although