Rhabdomyolysis

and bipolar affective disorder may accompany serotonin syndrome as primary diseases • Treatment is directed toward symptomatic and supportive care (e.g., benzodiazepines for restlessness, paralyzing agents for body temperature regulation) • Rhabdomyolysis is a nephrotoxic complication that may result from muscle breakdown following severe hyperthermia • Prognosis depends on etiology but most cases show improvement, if not resolution, within a day or two URGENT ACTION • Aggressive cooling is of

Myotoxicity can also progress to rhabdomyolysis and therefore can be deadly(B). Although this adverse reaction has been universally acknowledge, the precise mechanism behind the reaction remains unidentified. A variety of hypothesis have been postulated which include; statin-induced interruption

can be fatal if it is not treated quickly. In most cases, there are no signs or symptoms until the reaction occurs. Signs and Symptoms The key symptoms of malignant hyperthermia are a dangerously high body temperature, severe muscle spasms, rhabdomyolysis, acidosis and a fast heart rate. Diagnosis and Treatment Genetic testing is available to determine if you are carrying the gene for malignant hyperthermia. There is a 50 percent chance of the patient having the condition if they have an immediate

Piperacillin/Tazobactam (Zosyn) is an antibiotic with a combination of a semi-synthetic beta-lactam antibiotic and beta-lactamase inhibitor. It is widely used in clinical settings because of broad spectrum bacterial coverage and low toxic effect. Piperacillin inhibits bacterial cell wall synthesis by binding one or more penicillin-binding proteins. Tazobactam is a beta-lactamase inhibitor and it exhibits synergy against many beta-lactamase-producing bacteria and extends the spectrum of activity of

DP was diagnosed with high cholesterol when he had experienced STEMI 5 years ago. He underwent stent placement to open up his arteries. Since than he is taking atorvastatin. Statins have shown to considerably decrease cardiovascular related morbidity and mortality. Long term statin therapy is recommended to prevent ischemic events in post-myocardial infraction. (2) However, DP get occasional muscle pain with atorvastatin that is abrupt and mild excepecilly after excessive physical activity. On average

CK rises in rhabdomyolysis within 12 hours of muscle injury, peaks in 1-3 days, and declines 3-5 days after the cessation of muscle injury. Whether the decision is made to perform a fasciotomy or not, aggressive fluid resuscitation and hemodialysis should be started if

Fifteen month old Jacob is brought seizing into our small rural emergency department by ambulance. He has been having generalised tonic clonic jerking movements and unresponsiveness for the past twenty-five minutes. He is accompanied by his very concerned mother. Jacob is immediately designated a category one triage as he is unresponsive, his life is in immediate danger as is having an ongoing and prolonged seizure. A Glasgow coma scale less than eight (his is three) means he is not able to protect

Title Effect of two intensive Statin regimens on progression of Coronary Disease. Citation Nicholls J. Stephen, Ballantyne M. Christie, Barter J. Philip, Chapman M. John, Erbel M. Raimund, Libby Peter, Raichlen S. Joel, Uno Kiyoko, Borgman Marilyn, Wolski Kathy, Nissen E. Steven. Effect of two intensive statin regimens on progression of coronary disease. New England Journal of Medicine. 2011 November 15 (2015 August 24); 365(22). Introduction Clinical trials have shown that statins, inhibitors of

clinical studies reported electrophysiological changes by RNS in patients with OP poisoning and attributed these changes to IMS (Avasthi and Singh, 2000). Findings of other experimental and clinical studies documented that IMS is associated with rhabdomyolysis which is followed by a proportionate rise in CPK and LDH levels (Bhattacharya et al., 2011). Taking the above mentioned studies in consideration, this study was carried out

CYP2D6 belongs to the Cytochrome P450 protein family. Its sequence length is approximately 500 amino acids, including a substrate binding site (\textit{Figure \ref{fig:cypsites}a}) and a heme binding site (\textit{Figure \ref{fig:cypsites}b}) and is generally present as a dimer. It is responsible for metabolizing up to 15\% of total drug uptake in the human body. More than 100 mutants have been reported with varying enzymatic activity. Many PGx-connected mutations cluster around important sites,