Rhabdomyolysis

Crush syndrome is a life-threating medical emergency in which rhabdomyolysis develops after prolonged compression of the limbs.7 It is most frequently characterized by hemodynamic shock, hyperkalemia, metabolic acidosis, and myoglobinuric acute renal failure. 7 Direct traumatic pressure initiates cell death through mechanical disruption of myocytes, followed by ischemic injury.7 After the release of pressure, ischemia reperfusion injury combined with an increase in vascular permeability cause

certain individuals, the use of general anesthesia can cause individuals to suffer from an inherited disorder known as malignant hyperthermia. When malignant hyperthermia is triggered, individuals are at risk of hypoxemia, metabolic acidosis, rhabdomyolysis and a quick rise in the person’s body temperature

pathway is the mode of action of most of the statins (2). Many side-effects must be understood and prevented throughout the use of statins. The most severe side-effect is rhabdomyolysis, which is characterized by damaging of the skeletal muscle which leads to the release of muscle proteins into the blood (3). Statin induces rhabdomyolysis that can be acute, subacute, or chronic, and may be permanent despite dose reduction or substitutions (4). Myoglobin release from the damaged muscle can lead to acute

Simvastatin Introduction Simvastatin is used to lower the cholesterol level in the blood such as the low-density lipoprotein (LDL) and triglycerides and to raise the high-density lipoprotein (HDL), It decreases the risk of heart diseases and helps to prevent the heart attacks and strokes by reducing the amount of cholesterol that is made by the liver (Raleys.com, 2015). Chemical structure and functional groups Simvastatin is one of the statins derivatives that is synthesised from a fermentation

Abstract Interactions between multiple drug substances, taken in combination or simultaneously, may yield excessive risk of adverse effect. However, this increase risk is not uniform for all combinations. Some combinations may show a constant risk pattern. Collections of individual reporting of an adverse event related to adverse drug reactions have proven to be very useful. A mixture model approach is applied to AERS (adverse effect record system) data to differentiate drug combinations following

Lactate dehydrogenase FUNCTION : Catalyzes enzyme that transfer a hydrogen from molecule to another molecule, which converts pyruvate to lactate and also converts NADH to NAD+ Location : found near all living cells and there is 4 different enzyme classes, 2 are cytochrome c-dependent enzyme (D-lactate or L-lactate) and 2 are NAD (P)- dependent enzyme (D-lactate or L-lactate) ` ` Reaction : Lactate dehydrogenase catalyzes the interconversion of pyruvate and lactate with associated interconversion

By learning about different viruses in class, it sparked my interest in further researching a common virus known to the word called West Nile virus. Affiliated with the genus Flavivirus, this virus can be transported globally due to being classified as a mosquito-borne arbovirus1. Mosquitoes, belonging to the genus Culex, can facilitate the transportation of this pathogen by consuming the blood of an infected bird, being the main reservoir, and then passing it on to another animal or human1-3. Mosquito

The Ryanodine receptors (RyRs) are membrane proteins that are located in the sarcoplasmic and endoplasmic reticulum of the cells. The key role of the receptors is to mediate the release of calcium ions (Ca2+) from intracellular storages in either reticulum into the cytoplasm during excitation-contraction coupling in muscles. Intracellular Ca2+ regulation is important for secondary messenger for signal transduction and is essential for certain cellular processes. Ryanodine is named after the plant

web site as well as at CrossFit events and centers around the country. It's easy for new comers to get swept away by the community and push themselves too far. One dire consequence for even the most experienced CrossFit athlete going too far is rhabdomyolysis. Simply put, your muscles cells explode, secrete a protein called myoglobin and your kidneys become over-taxed trying to clean these proteins up. This is a potentially lethal condition that should be avoided at all

A 50 years old lady was admitted to our hospital with complaints of generalized body aches, cramping sensation of forearms and calves, followed in a day by weakness in all limbs and difficulty in walking and carrying out daily activities seven days prior to hospital admission. There was no preceding history of trauma, intensive physical exercise, use of medicinal or illicit drug abuse, fever, seizures, loose stools, nausea, vomiting or decreased urine output. She used to take hadia (local country