Senescence

Senescence, being the biological term for aging, is unstoppable so far in scientific discovery. It is known that humans are constantly aging over the course of their life, but there are many theories regarding what exactly causes aging. 2 of the main theories are that aging is a process that our cells have programmed within them, and that aging is the cumulative effect of damage to our bodies over the course of our lives. Ultimately, aging is down to many more factors than just these, like changes

Plant senescence is a highly controlled physiological process that leads to plant death, it is also known as the last development stage of a plant. The PCD, (Programmed Cell Death) is a program instilled into all kinds of plants and promotes its own individual death, a sort of “program” produced during plant development and the plants’ stress response systems. During the senescence process, the cells undergo a dramatic transition in its cellular replication, metabolism and cellular structures. The

Timing of senescence can lead to overall yield decline, especially if it occurs during a critical period like grain-filling. In the present study, we shed light on addressing problems associated with early senescence, through characterization of microbial communities in the rhizosphere of rice isogenic lines at grain-filling stage. We further correlated some physiological traits associated with early senescence and the identified root microbiome. Our results are unique in that they revealed that

Senescence in the phrase “effects of senescence on physiology”, refers to the complex process of ageing that eventually leads to death. Therefore, effects of senescence to physiology refers to how biological processes and organs within the human body change as a result of one growing old (Shock, 2015). In addition, the author points out that the performance of organs such as heart, kidneys, brains or lungs decreases as a result of cell death due to the decreased ability of the body to produce or

than Younger People Humans undergo several stages during their lifetime including growth, development, reproduction and senescence. Senescence is defined as the deteriorative biological changes that organisms experience as they age eventually leading to death. These changes include low metabolism, a weak immune system, memory loss, poor vision and loss of hearing. Senescence begins in humans during their post-reproductive years. However, gerontology research has shown that individuals who reproduce

other aging indexes, including high risk of premature death and development of cancer. It has been found believable that the presences of short telomeres trigger cell senescence in vivo, in consequence affecting organ and tissue function. Their observation strongly support that telomere shorting is a major cause of cell senescence in organs with high proliferative potential, detectable in aged human individuals. Which causes the degeneration of organs and bones that lead to the age related diseases

Heterogeneous ribonucleic proteins (HNRNPs) are a family of RNA binding proteins that play a key role in various metabolic functions of RNA. There are roughly twenty major hnRNPs which are readily found in large quantities in the nucleus and in some cases in the cytoplasm. hnRNPs are expressed throughout all tissues at different levels depending on the hnRNP (Kamma et al. 1994). hnRNP metabolic roles include polyadanilation, shuttling mRNA out of the nuclear envelope, telomere biogenesis and localization

TELOMERASE AND LIMITLESS CELL PROLIFERATION Introduction Normal human diploid cells have a finite proliferative life-span and enter a non dividing state termed replicative senescence, due to the existence of an internal clock in the cell. This internal clock results to be telomere shortening after very mitotic replication. Telomeres are composed of (TTAGGG)n repeats at the end of chromosomes.1 Telomere length is regulated by telomerase, which is a reverse transcriptase that elongates the telomere

In particular: a) species which show no aging (“animals with negligible senescence”) show the same telomerase activity at any age and have no cancer problem, as demonstrated by their constant mortality rate at any age; b) in our species, studied in wild conditions, the increase in age-related mortality is precedent to cancer-related deaths cases and it is impossible that defenses against cancer kill before cancer can develop; c) shortened telomeres, as a result of telomerase inactivity, cause dysfunctional

in a manner in which appropriate cells in the region can readily absorb them. This must be done without invoking an inflammatory response (Browder). Aging, also known as Senescence, is a natural process, “beginning at reproductive fitness and culminating in death,” Observed in most living organisms, senescence is characterized by a gradual reduction in “reserve capacity of organ systems”, (Heydari). Supporting research by U. of Florida’s Aging Biochemistry Laboratory indicates an increased