Sepsis

Advanced Glycation End Products in Pediatric Sepsis : A pilot study Abstract BACKGROUND: Sepsis in pediatric patients still a leading cause of morbidity and mortality. AIM: To determine whether serum level of receptor for advanced glycation end products (RAGE) could be used as a potential diagnostic and prognostic marker in septic child. METHODS: A pilot study on pediatric intensive care unit patients over a 1year period with clinical evidence of sepsis. Forty patients were enrolled in the study

CLASSIFICATION 1 • There is a disease continuum with increasing severity if not treated or not responsive to treatment o Sepsis - Infection plus overwhelming systemic response to infection o Severe sepsis - Sepsis plus organ dysfunction and tissue hypoperfusion o Septic shock - Severe sepsis plus organ failure DIAGNOSIS CLINICAL PRESENTATION • History o Recent

Sepsis continues to be a major cause of death and morbidity in the intensive care unit (ICU), with documented mortality rates as high as 50% (Nargis, Ibrahim, & Ahamed, 2014). It is also estimated to be the principal cause of death and illness worldwide (Singer et al., 2016). Moreover, the socioeconomic costs related to sepsis were determined to be more than $20 billion in 2011 in the United States (Balk et al., 2017). Also, there has been a steady increase in the incidences of sepsis as the technological

Sepsis, also referred to as blood poisoning is a potentially life threatening complication that results from an infection. These infections, typically caused by bacteria cause chemicals to be released in to the bloodstream in order to fight the infection. As a result, this triggers an inflammatory response throughout the body, which in turn may cause a cascade of changes, which may damage organ systems, causing them to fail. The infection present in the blood in this case becomes systemic, spreading

The term “sepsis” has been around since prehistoric times. Hippocrates presented the word sepsis 2400 years ago to represent a condition where an overwhelming infection leads to tissue breakdown with rotting, foul odour, and disease. The ancient Roman scholar and writer (116 BC–27 BC), Marcus Terentius Varro mentioned that “small creatures, invisible to the eye, fill the atmosphere, and breathed through the nose cause dangerous diseases.” In the early 1990s at a conference convened by the American

According to the authors, Bernstein & Lynn (2013), “A common and devastating condition, sepsis has significant healthcare implication worldwide.” The authors elaborate on the different types of sepsis and the complications that arise from them along with the pathophysiology and risk factors. Bernstein and Lynn emphasized the importance of a proper nursing assessments, recognition of septic progression and nursing interventions. An individual can get a septic infection from many sources, such as

is to analyse the care of a septic patient. While discussing the relevant physiological changes and the rationale for the treatment the patient received, concentrating on fluid intervention. I recognise there are other elements to the Surviving Sepsis Bundles, however due to word limitation; the focus will be on fluid intervention. The essay will be written as a Case Study format. To maintain patient confidentiality any identifying features have been removed in keeping with the Nursing and Midwifery

Sepsis: Early Detection and Implementation of Sepsis Resuscitation Bundle Introduction Sepsis is defined as the body’s inflammatory response to an infection and can quickly lead to multiple organ failure and death. Early, goal-directed therapy using the sepsis resuscitation bundle introduced in the “Surviving Sepsis Campaign” is the treatment used throughout the world for sepsis treatment (Winterbottom 2012, pp 247). There are approximately one million cases of sepsis in the United States

Early identification of sepsis is crucial when caring for patients at risk for sepsis. The earlier sepsis is identified the sooner health care professionals can implement treatment, which can prevent the disease from advancing into septic shock. “Sepsis can lead to shock, multiple organ failure, and death, especially if it is not recognized and treated promptly. Sepsis remains the primary cause of death from infection despite medical advances that include vaccines, antibiotics, and acute

Sepsis is a phenomena that is commonly seen in the acute and critical care setting. Sepsis is defined by the Global Sepsis Alliance ([GSA]; n.d.) as “the body's overwhelming and life-threatening response to infection which can lead to tissue damage, organ failure, and death” (Global Sepsis Alliance [GSA], n.d., para. 1). Severe sepsis and septic shock are major healthcare complications that affect millions of individuals each year, worldwide. Dellinger et al. (2013) states that sepsis causes one