Statin

Statins (also known as 3-hydroxy-3-methylgutaryl coenzyme A reductase inhibitors) are widely prescribed cholesterol-lowering drugs for the treatment of dyslipidemia and cardiovascular disease. Although they are considered to be drugs with a very good safety profile, there are many concerns that their adverse effects might compromise their proven beneficial effects due to their extensive usage. Even though more aggressive lipid lowering with potent statins in high doses can reduce rates of non-fatal

Statins are drugs used in the treatment of many diseases including hypercholesterolemia, ischemic heart disease (angina, chronic heart disease and myocardial infarction), cerebrovascular accidents and peripheral arterial disease. Adults with a history of cardiovascular disease (CVD) or those with a 10-year risk of developing CVD should start statin therapy as a prophylactic measure. As a result of all these indications, statins are one of the world’s most prescribed drugs (1). Many forms of statins

ASSESMENT OF THE EFFECT OF STATINS IN LOWRING THE RISK OF STROKE AND PREVENTING CEREBRAL ISCHEMIA IN PATIENTS WITH HYPERCHOLESTEROLEMIA Introduction Stroke is a world wide common disease with its occurrence depending on multiple risk factors involved, one of which is high blood cholesterol and LDL level, it is thought that lower cholesterol level decreases the incidence of cerebrovascular ischemia (doc3.pdf) which has been concluded from many clinical trials conducted for the purpose of understanding

Camille Pargo Journal Club 7/15/2015 Article Title: Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes Authors: Cannon CP, Blazing MA, Giugliano RP, et. Al Executive Committee: Representatives from Thrombolysis in Myocardial Infarction (TIMI), Duke Clinical Research Institute (DCRI), and Merck & Co., Inc. Enrollment Centers: Representatives from 1158 enrolling centers in 39 countries Journal: The New England Journal of Medicine Funding: Merck Journal citation: N Engl J Med 2015;372:2387-2397

effects of statins, drugs that have been manufactured primarily for the purpose of controlling blood cholesterol level, statins are defined as a family of drugs that control and inhibit cholesterol production by acting through binding to 3-hydroxymethyl-3-glutaryl coenzyme A (HMG-CoA) reductase, by this mechanism the end result will be a lower LDL level in the blood which in turn benefits the outcome of many states of disease including cardiovascular disease and stroke (doc1.pdf-[1]) Statins has multiple

Statin pills, including Lipitor, which can be prescribed to decrease cholesterol levels, paintings partly through interfering with the activity of HMG-CoA reductase. If your cells take place to want more LDL cholesterol below certain circumstances, but the statin drug is blockading this essential enzyme, your cells won 't be able to make cholesterol whilst wished. And what’s worse is that the cholesterol synthesis pathway doesn’t just make LDL cholesterol; branches of this same pathway are liable

Methodology- Specific Aim 2 In the second part of this proposed dissertation, the protective effects of statins will be evaluated by quantifying the effects of their use on clinical outcomes among bacteremic patients in a large, nationally representative cohort. A retrospective cohort study design will be used to assess multiple outcomes, such as inpatient mortality and length of hospital stay, among statin exposed v/s non-exposed patients. A retrospective cohort study is an analytical study in which individuals

Introduction Hyperlipidemia is the abnormal elevation of any lipoproteins present in the blood. HMG-CoA reductase inhibitors (statins) are commonly used for the treatment of hyperlipidemia, specifically lowering the levels of low-density lipoproteins (LDL) levels. As with most classes of medications, there are many potential side effects. A less common but serious side effect of statins is myopathy. Myopathy is a dose-related side effect that causes skeletal muscle weakness, aching, cramping, pain, stiffness

2 Rhabdomyolysis is only rarely observed in patients undergoing fenofibrate therapy, and is often present with confounding factors, calling into question the association.2(p927) However, Rhabdomyolysis is also a well known potential side effect of statin drugs, so it is not out of the question that other lipid lowering drugs may have similar effects.1(p909) In this paper, we will look at the current literature surrounding

Lowering Cardioprotective effect of statins is ascribed by lowering LDL-C and improving the lipid profile as reflected in plasma cholesterol levels. Statins and Endothelial Function Vascular endothelium plays a role in both vasoconstriction and relaxation, while hypercholesterolemia by modulating arterial tone adversely affects this process. However, endothelial function is improved by statin therapy due to production of the vasodilator nitric oxide. Statins and Plaque Stability The degree of rupture