Statin

used to treat high cholesterol. Statins are the number one drug used to treat high cholesterol. Statins can lower the risk of heart attack or stroke. Other medications can improve cholesterol levels, but they have not been proven to lower the risk of a heart attack or a stroke. Statin side effects can be uncomfortable, making it seem like the risks outweigh the benefits of these powerful cholesterol-lowering medications. (Mayo Clinic Staff) Side effects of statin is muscle pain and damage, liver

MindByte #3 Matteo Rocco Lawrence Caprio I want you to read the following article,” How statistical deception created the appearance that statins are safe and effective in primary and secondary prevention of cardiovascular disease”, David m. Diamond and Uffe Ravnskov; Expert Rev. Clin. Pharmacol. Early inline, 1-10 (2015) a) On the first page, Hill’s criteria for causality is referenced. I now want you to research the term; “(Bradford) Hill’s criteria for causality” and list six of the possible

prevention? It would be recommended for ML to start a lipid lowering medication like a statin. The National Heart, Blood and Lung Institute recommends moderate to high intensity statins to people who fall into groups such as diabetic patients with a LDL from 70-189 (Ng, P., Toderika, & Cheng-Lai, 2016). ML would fall into this category and would most likely benefit from starting a medication such as a statin. Prevention would also be very important with ML. Currently she is at a high risk of having

along with some statin medication of Atorvastatin, to help lower the cholesterol within the blood and help to prevent the patient from gaining any associated symptoms that are related with cardiovascular disease. The medication was given as it inhibits HMG-CoA reductase of the enzyme found within the liver that has a huge role in the production of cholesterol. This should show a dramatic reduction in the levels of LDL-C. Ezetimibe was also given to the patient along with the statin drug to lower cholesterol

The article, ‘Statins: mechanisms of action and side effects’ describes the mechanism in details. The rate-limiting enzyme in cholesterol synthesis causes a decrease in cellular cholesterol concentration. As the cholesterol concentration decreases it activates a cellular

earlier age because Familial Hypercholesterolemia can lead towards a decrease in cardiovascular activities and even death in those diagnosed with the disease. Heterozygous FH patients are treated with statin medications that inhibit an enzyme responsible for the production of cholesterol. Statins are usually given to a patient in a combination with one or more other drugs. For example, ezetimibe, bile acid binding resins, and niacin are potential drugs that would be combined. Bouhairie claims this

and dihydroergotamine are less effective oxytocics than ergonovine, they can be given orally or intravenously , it is currently used in obstetrics to treat or prevent post partum uterine atony and to complete an incomplete or missed abortion. Statins :

An aspect of aging that I have often grappled with is the increased incidence of dementia and Alzheimer’s disease that we have seen in the last 20 years. I remember vividly, as a psychiatric nurse that started my mental health in an inpatient geriatric facility, we often had patients that were admitted in our facility that either suffered from bipolar, schizophrenia and lastly older people that were depressed either due to loss of a spouse and were grieving. At that time, only about 10-20% of our

to utilize statin treatment, for several reasons. Hence, the need to develop others forms of therapy in order to lower lipid levels. Inhibiting ACL is able to reduce fatty acid synthesis, which ultimately lowers levels of malonyl CoA, however with ETC-1002 it occurs without directly inhibiting HMG-CoA. This therapy corrects imbalances among lipid, as well as carbohydrate metabolism. Patients that may benefit from this therapy are those that experience muscle pain or weakness from statins, individuals

The use of RGGT inhibitors doesn’t exhibit any toxicity in mouse models (Taylor et al., 2011). This is supported by comparison to gunmetal mice that harbour a RGGT mutation leading to 80% reduction of RGGT function. There are mild dysfunctional phenotypes such as hypopigmentation and altered platelet synthesis. This suggests that a decreased RGGT activity, such that Rab proteins would be hypoprenylated, would not be lethal if targeted (Recchi and Seabra, 2012). The decrease in RGGT activity is only