Substantia nigra

researchers in this paper maintain this is obviously a direct result of the lack of insight into the pathogenesis of the disease. Parkinson’s disease is the product of the deaths of a number of dopaminergic (dopamine-secreting) neurons in the substantia nigra pars compacta region (SNc) of the brain. But what causes these deaths? In the paper “‘Rejuvenation’ protects neurons in mouse models of Parkinson’s disease,” Chen and researchers find that older neurons in the SNc are unusually reliant on calcium

The basal ganglia is comprised of the caudate and the putamen (together these form the striatum), the globus pallidus (internal and external), substantia nigra and the subthalamic nucleus. These components work together in order to coordinate the motor movement of the body. The basal ganglia works with the motor cortex of the brain to execute these motor movements. In the direct pathway signals are

symptoms or tremors, rigidity, (bradykinesia) or slowness of movement and posture instability. Parkinson’s involves the malfunction and death of vital nerve cells in the brain. This disease primarily affects neurons in area of the brain called substantia nigra. Some of these dying neurons produce dopamine a chemical that sends messages to the part of the brain that controls movement and coordination. The symptoms of Parkinson’s disease usually begin on one side of the body and within time spread to

Parkinson’s disease (PD) is a neurodegenerative disease which is progressive, incurable and debilitating. The disease is caused by a loss of dopamine producing neurons in the brainstem which leads primarily to motor deficits. In Australia, 1 in 350 people live with PD and the prevalence is quickly growing (Parkinson 's Queensland, 2014). While most of the people diagnosed with PD are over 65 years old, people as young as 30 can develop the condition (Parkinson 's Queensland, 2014). Currently, there

Introduction In 1817, James Parkinson first described a disease, later to be known as Parkinson’s Disease (PD) as a; neurodegenerative disorder affecting the physical, psychological, social, and functional status of individuals (Parkinson Society Canada Staff, 1965). In the time since the disease was first described, the frequency of individuals affected with the disease has increased, with no single cause yet to be identified as the culprit for the onset of the disease. According to the Parkinson’s

loss of particular neurons called dopamine neurons, dopamine neurons are able to produce a signalling chemical, dopamine. This chemical is important for allowing the body to make normal movements, primarily dopamine neurons are found in the substantia nigra area of the brain, it is located in the mid brain above the spinal cord; when these neurons are lost there is a reduction in the amount of dopamine in the brain. There are four main, movement symptoms associated

in her mid-thirties she was diagnosed with early onset Parkinson’s Disease. “Parkinson's disease (PD) is a neurodegenerative disorder that affects predominantly dopamine-producing (“dopaminergic”) neurons in a specific area of the brain called substantia nigra” (What Is Parkinson’s?). Most people when they think of Parkinson’s disease they only think of the tremors that it causes, but there is so much more to it than that. Some of the symptoms of PD are: slowness of movement, rigidity or stiffness

condition called Canine multiple system degeneration (O’Brien, 2005). Affected dogs develop cerebellar ataxia, which later develops into akinesia and the inability to maintain postural stability. As the disease progresses, it has been seen that the substantia nigra degenerates, which is similar to Parkinson’s Disease (Montgomery, 1983). Eventually, the dogs are euthanized by age 2. For studies involving Parkinson’s Disease, mice and non-human primates are primarily used as models. 1-methyl-4-phenyl-1,2

Understanding Huntington's Disease Diagnosis of Huntington's Disease Today, a blood test is available to diagnose a person displaying suspected Huntington's symptoms. The test analyzes DNA in the blood sample and counts the number of times the genetic code for the mutated Huntington's gene is repeated. Individuals with Huntington's Disease usually have 40 or more such "repeats;" those without it, 28 or fewer. If the number of repeats falls somewhere in between then more extensive neurological

Parkinson 's disease Twanda H. Lewis North Carolina Wesleyan Dr. Quinan Parkinson 's Disease Twanda H. Lewis North Carolina Wesleyan Dr. Quinan Outline Abstract………………………………………………………………………………………5 Introduction………………………………………………………………………………. 6 Symptoms…………………………………………………………………………………. 6 Tremor…………………………………………………………………………………….… 6 Slow Movement………………………………………………………………………… 6 Rigid Muscles…………………………………………………………………………….. 7 Disfigured Posture…………………………………………………………………….. 7 Loss of