Telomere

exist. However, new research being conducted on telomeres and telomerase provides insight on not only the aging process and mortality of cells, but also on how the idea of cell death connects to cancer cells. By gaining knowledge on the supposed immortality of cancer cells, researchers are acquiring a higher understanding of the subject, and attempting to work on alternate techniques to provide treatment for the illness. The connection between telomeres and cancer and the momentous discoveries being

Conglomeration of Scientific Literature Focused on Chromosomal Telomere Length (TL) In Blood Leukocytes, Sputum, and Buccal Cells as It Relates to Cancer Occurrences by: Andy Barajas Bio 490, Fall 2014 Department of Biological Sciences California State Polytechnic University, Pomona Abstract This is a conglomeration of scientific literature as it relates telomere length in blood cells to the occurrence of cancer. Telomeres are composed of repeating TTAGGG nucleotides and they are found at the ends

function; one of these is called a Telomere and is found at the ends of the chromosomes. Telomeres contain thousands of repeats of the repetitive TTAGGG DNA sequence; this is combined with a complex enzyme known as telomerase. Furthermore, the function of this ribonucleoprotein enzyme complex is to maintain telomere length in cancer cells by adding TTAGGG repeats onto the telomeric ends of the chromosomes; this compensates for the normal expected shortening of telomeres which occurs in all dividing cells

Poole 15 March 2017 Shorter Telomere Length in People with Schizophrenia: A Preliminary Study from Australia Journal: Schizophrenia Research March 2017 Authors: Cherrie Galletly, Varinderpal S. Dhillon, Dennis Liu, Ryan P. Balzan, Lisa A. Hahn, Michael F. Fenech Hypothesis: Since those with schizophrenia have lower life expectancy, scientists have often wondered if schizophrenia was connected to telomere The authors were only testing for a correlation between telomere length and schizophrenia diagnosis

Aging, it’s something that as a species of life on this planet we are predisposed to and its results are an inevitable factor that effects our bodies in several ways, from cataracts development to the progression of memory issues from such diseases as Alzheimer’s or Huntington’s. The concepts of aging are broken down into two theories widely accepted by several varying fields of studies such as gerontology, the study of the aging process, and oncology, the study of cancer and tumor development. The

illnesses or stressful situations. But this is not the first study that correlates telomere length with a healthier lifestyle. In 2008, a study found that comprehensive life changes like a better diet, physical exercise and stress management increased telomerase (the enzyme that produces telomeres) activity in men with prostate cancer. The bottom line But the findings didn’t end there. One thing is to stop telomeres from shortening. Another is to actually lengthen them. A study from Harvard University

reported much more stress, understandably, than the control group who had healthy children. The scientists then decided to look at the mother 's DNA. What they found was shocking... See, each strand of DNA is protected by little shields called telomeres. Telomeres are kind of like

and it was later shown that telomere shortening was just slowly counting down to the deterioration of the cell (Okereke, Prescott, & Wong, 2012). Telomeres are shortened due to the fact that DNA polymerase are not able to copy the end of the strands that it is replicating. This causes it to shorten, then when it is duplicated once again it is shortened even more, and this process just keeps continuing until the telomere is too short to complete its copying. When telomere lengths become too short,

help us to explain this phenomenon. We would also like to screen several oncogene and tumor suppressor gene expression in order to study the potential carcinogenesis effect of this material. 2. OBJECTIVES 2.1 To evaluate the differential in telomere length of the cells grown on the TNA and the test-control materials. 2.2 To measure the expression of telomerase activity in the cells that grown on the TNA and test-control materials. 2.3 To study the TNA effect on the genetic changes using metaphase

Interestingly, studies from our laboratory and others have demonstrated a stereochemical dependence for dSp processing by enzymes in ODNs. The first instance of a dSp diastereomer difference was reported from our laboratory when Klenow Fragment (exo-) was allowed to insert dATP opposite the isomers for which dSp1-containing ODNs were found to be the more favorable substrate for insertion and bypass.32 This study was extended to in vivo experiments by Neeley, et al. to include pol II and pol IV