Thalassemia

Orofacial characteristics of β –thalassemia major patients among the UAE population Introduction Beta thalassemia is a genetic disorder in which the gene for the production of beta globin chain is defective. The name thalassemia is derived from a combination of two Greek words: thalassa meaning the sea, i.e. the Mediterranean, and anaemia (“weak blood”). Therefore it is also known as Mediterranean anemia. Another name for beta-thalassemia is Cooley’s anemia, named after Prof. Thomas Cooley

Story about mother and brother B. Information about beta thalassemia 1. Common in people of African, Mediterranean, Asian and Middle Eastern descent 2.Thalassemia is the most common genetic disorder worldwide with beta thalassemia has the most common of the group due to the more than 250 mutations in hemoglobin beta have been linked to causing Beta thalassemia (according to the DNA Learning Center) II.What is Beta Thalassemia? A. Beta thalassemia is a genetic disorder that disturbs the normal production

Thalassemia is basically a name for similar groups of inherited blood diseases that involve missing or abnormal genes regarding the protein in hemoglobin which is the red blood cells that carry oxygen throughout the body. I will discuss the different types of Thalassemia, how Thalassemia is diagnosed, and the treatments available. I will also discuss the complications and side effects of the treatments, the disease’s causes and effects, and how it is more dominant in some parts of the world than

Clinical Genetic Disorder: Beta Thalassemia I. Creative Writing John and his wife Mary decided that after 3 years of marriage that it was time for them to bring a child into their life. John and Mary lived on the coast of Greece, where the weather was always sunny and the water not but a stone toss away. John and Mary decided it was the right time, the, 9 months later they conceived a son, they named him Henry. During the first two years of Henry’s life John and Mary noticed abnormalities

……3 • Why we are choosing this issue (Thalassemia)?……….………………..…3 • What is Thalassemia?………………………………….…………………...3 • Types of Thalassemia……………………...……...….…………………….3 o Alpha Thalassemia…………..………………....………………….….3 o Beta Thalassemia…………………………..…………………………4 • Treatment of Thalassemia………………………….……………………….4 • The effects of Thalassemia………………………...……………………….4 • What can be done to resolve Thalassemia? ……..…………………………4 • Reference…………………………………………………………………

Thalassemia is a blood disorder transferred through families. It occurs when the body makes less hemoglobin than needed or an unusual form of hemoglobin. Hemoglobin is the protein in red blood cells that carry oxygen. The disorder makes an excessive amount of destruction of red blood cells. This eventually leads to anemia. There are two main types of thalassemia. The first one is Alpha thalassemia. This occurs when a gene or genes related to the alpha globin protein are missing or mutated. It happens

SUBJECT CODE : MPU 3323 SUBJECT TITLE : PERSONAL HEALTH MANAGEMENT PROGRAMME : BAAF CURRENT YEAR : YEAR 2 SEM 1 INTAKE : SEPT 2014 NAME/SEGI ID/UOG ID : SHAMITA A/P KASINATHAN (SCSJ-0019803/000862417) LECTURER’S NAME : MISS BALWINDER KAUR LEARNING CENTRE : SEGI COLLEGE SUBANG JAYA SUBMISSION DATE : 26 OCTOBER 2015 INTRODUCTION TO HEREDITARY DISEASES Heredity can be characterized as the

137 5*1.220 = 6.1% 0.137/6.1 = 2.246 HbA2% This result gives HbA2 of 2.246 suggesting the individual may not have the β-thalassemia trait hence normal or they could be β-thalassemia homozygous. The range for β-thalassemia homozygous is 2.8-3.5 and the range for normal individuals is 1.5-3.0. So this individual could be either as their, to find out if the patient has β-thalassemia or not, results from HbA2 must be taken in account with the patients history, total haemoglobin values and other lab tests

(3-2) Dickey Fuller test results expanded Philip -Perron: To confirm previous results we conducted Dickey Fuller expanded testing (ADF) and Philip -Perron (PP) the leftover tests are shown in Table (4) shows the results of testing the stability leftover downhill co-integration equation. (4) Results of the study of the causal relationship between blood and iron: Granger demonstrated that the existence of a co- integration between two variables means that there is a causal relationship in one direction

translation (nonsense, frameshift, and initiation codon mutations). In rare instances, the defect does not lie in the beta globin gene cluster. Some mutations in the X-linked transcription factor GATA-1 may produce thrombocytopenia associated with thalassemia trait, whereas molecular lesions affecting the general transcription factor TFIIH result, in addition to