Transcription factor

This research paper is about “An analysis of variation at transcription factor binding sites in Drosophila and humans”. This analysis is done in order to investigate the transcription factor binding sites variability with the comparison of ready published data of transcription factor binding maps for Drosophila isogenic lines and human individuals. Genome is considered as the encoder or provider of disambiguation for many diseases, viruses, DNA and other organisms. Here it is very important to understand

This research paper is about analysis of variation at transcription factor binding sites in Drosophila and humans. This analysis is done in order to investigate the transcription factor binding sites (TFBS) variability with the comparison of ready published data of transcription factor binding maps for Drosophila isogenic lines and human individuals. In this paper it is very important to understand the concept of population genetics. Population genetics explains the study and research of distributions

regulating eukaryotic transcription came from studies using viruses. Viruses utilize the machinery of the infected cell to transcribe the viral genome and synthesize more viral particles. Therefore, in the 1970s and 1980s several groups were using viral gene systems as a convenient tool to investigate eukaryotic transcription. The members of the ATF family of transcription factors were similarly discovered in the late 1980s by researchers trying to identify cellular factor(s) involved in the coordinated

INTRODUCTION Regulatory factor is bound with genomic DNA to protect the sequence from cleavage through DNase I. With the help of DNase I, it is easy to identify the 41 diverse cells with nucleotide resolution. Around 45 million transcription factors are detected in the regulatory regions. They represent the binding to the elements that are of short sequence. Genetic variations affect the allelic chromatin which is present in concentrated manner in the footprints. But these variations effects are

Yahya Bello To test whether chemokine receptor CXCR3 mediates gene transcription Introduction SAA (Serum Amyloid A) function is similar to a C- reactive protein (an annular pentameric protein that is mostly found in blood plasma and its levels rise in response to inflammation. It considered as an acute-phase protein of hepatic origin, which increases following interleukin-6 secretion by macrophages and T cells) but acts as an acute phase protein, which can be used as an indicative, predictive or

Grainyhead (Grh) gene family Grainyhead (Grh) genes are conserved in metazoans. They encode a family of transcription factors with a unique, unusually large, DNA-binding and dimerization domain, and an isoleucine-rich activation domain(Attardi and Tjian, 1993; Gustavsson et al., 2008; Moussian and Uv, 2005; Ting et al., 2003b; Uv et al., 1994; Venkatesan et al., 2003; Wilanowski et al., 2002). Grh factors were first identified in Drosophila (Bray et al., 1989; Bray and Kafatos, 1991; Dynlacht et al., 1989;

and p73 play a role in normal developmental biology (2). Structure of p53 P53 functions primarily as a transcription factor, and is biologically active as a homo-tetramer comprising of 4 X 393 amino acid residues. Each monomer comprises of several functional domains: 1. An acidic N-terminus transcription-activating domain 1 and 2 (TAD1/2) - This region interacts with various transcription factors 2. Proline-rich region (PRR) - This plays a role in p53 stability 3. Central DNA binding domain (DBD)

transcriptional influence across the node and into the right lateral plate mesoderm. Additionally, the level of Pitx2 was shown to be bilaterally amplified in the absence of Lefty2 (Meno et al., 2001). The Pitx2 protein is a bicoid-related homeodomain transcription factor involved in left-right asymmetric cardiogenesis as well as development of eye and craniofacial regions (Hjalt et al., 2000). Most interestingly, experimental murine models utilizing targeted loss of Pitx2 function resulted in severe cardiovascular

Homeobox genes act as transcription factors, found in eukaryotes. Homeobox genes are associated with many body structures such as the central nervous system, neural crest, skeleton muscle, heart, brain, and liver (1). Homeobox genes are highly conservative and consist of 180 base pairs. Homeobox genes had isolated from Xenopus, mouse, and humans. In the human genome, there are about 255 homeobox genes (1). The well-known homeobox gene is HOX gene. Such a mutation in one of these genes leads to phenotype

tor binding sites in Drosophila and Humans INTRODUCTION This research paper is about analysis of variation at transcription factor binding sites in Drosophila and humans. This analysis is done in order to investigate the transcription factor binding sites (TFBS) variability with the comparison of ready published data of transcription factor binding maps for Drosophila isogenic lines and human individuals. In this paper, it is very important to understand the concept of population genetics. Population