Tyrosine

Experiment Results Predict Question: Predict Question 1: Make a prediction about the basal metabolic rate (BMR) of the remaining rats compared with the BMR of the normal rat you just measured. Your answer : b. The hypophysectomized (Hypox) rat's BMR will be higher than the normal rat's BMR. Predict Question 2: What do you think will happen after you inject thyroxine into the three rats? Your answer : c. The hypophysectomized rat will become hyperthryoidic and develop a goiter. Predict Question 3:

Introduction Crayfish (Procambarus clarkii) are crustaceans that are similarly related to crabs, lobsters and shrimps. They live in partly salty water (brackish water), rivers, ponds and are considered omnivores because they feed on small fishes, plants, detritus, mollusk, and other small invertebrates. Crayfish have a hard-calcified exoskeleton which is typically made of structural polysaccharide called chitin. This calcified exoskeleton must shed for the crayfish to grow (Fitzgerald, 2006). Crayfish

Key Research Data and Analysis Study 1: Ipc1 controls the Pkc1 activation by modulation of DAG Regulation of DAG and phytoceramide by Ipc1. When Wild type and GAL7::IPC1 strains were exposed to galactose and glucose, DAG (activator of PKC1) levels in the GAL7::IPC1 strain increased when IPC1 was induced by galactose, and decreased when IPC1 was repressed by glucose. Furthermore, phytoceramide levels were increased when IPC1 was down regulated by glucose in the GAL7::IPC1 strain. In both wild

mesylate) Antineoplastic MW = 589.7 g/mol pKa = 5.5 Chemical Formula = C29H31N7O ● CH4SO3 IUPAC name: N-(4-methyl-3-{[4-(pyridine-3-yl) pyrimidin-2-yl]amino}phenyl)-4-((4-methylpiperazin-1-yl) methyl]benzamide Description Imatinib mesylate is a protein tyrosine kinase (RTK) inhibitor that exhibits high specificity and potency for ABL, c-kit, and PDGF receptors, which often harbor activating mutations and are typically mutually exclusive of each other and within specific cancer types.2 The compound has been

Short overview The current technology is based on protein kinase activation by means of stochastic resonance mediated through pulsed electrical fields of very low signal strength. The mode of action reveals how even small pulsed electrical fields can have a major influence on cellular function and physiological consequences. It is well known that biological sensory systems transform analog quantities such us pressure, temperature, electric fields (E-fields) etc. into trains of information. All

human c-abl oncogene, which becomes fused to the breakpoint cluster region (bcr) in the Philadelphia chromosome, following translocation. Presence of this bcr-abl gene fusion produces a poorly regulated tyrosine kinase, which results in a much higher level of cell proliferation. The action of this tyrosine kinase results in chronic myelogenous leukemia (CML) symptoms, such as overproduction of white blood cells. 2) Opposed to structural data alone, NMR

Bromophenols have been identified as potential therapeutics for treating type 2 diabetes mellitus (T2DM) due to their suspected tyrosine phosphatase 1B (PTP1B) inhibitory activity. A new series of bromophenol analogues will be synthesised and their PTP1B inhibitory activity will be tested in in vitro enzymatic assays to elucidate their mechanism of action as PTP1B inhibitors. Background and Introduction Type 2 diabetes mellitus (T2DM) is a metabolic disease that is caused by insulin resistance

An antimetabolite, 5FU is a pyrimidine analog that irreversibly inhibits TS. Thymidine is a nucleoside and a major component of the DNA and is hence required by cells for proliferation. Deoxyuridine monophostate (dUMP) upon methylation by TS generates thymidine monophostate (dTMP). 5FU interrupts the activity of TS and creates a shortage in the levels of dTMP. Thus the rapidly proliferating cells undergo death due to lack of thymidine nucleoside. The drug has successful applications in colorectal

DISSEMINATED GERMINOMAS The Therapeutic Challenge INTRODUCTION The prospect of tumours in the paediatric population is heart wrenching for parents and caregivers alike. The instinctive need for humans to care and protect their offspring leads to emotions of despair, anguish and hopelessness. Neurosurgeons are familiar with these emotions, as brain tumours represent the second most common paediatric tumour(1). Germinomas, even though rare, are unique to the paediatric population and adequate

Methanogens are prokaryotes. A prokaryote cell does not contain a membrane-bound nucleus; they range from 0.1 to 10 µm in total cell size. Methanogens are usually either coccoid (spherical) or bacilli (rod shaped). Each cell is surrounded by a plasma membrane. The cell has no subcellular organelles, only infoldings of the plasma membrane called mesosomes. The deoxyribonucleic acid (DNA) is condensed within the cytosol to form the nucleoid. The cell walls of Methanogens, like other Archaea, lack