4. (3 points) Consider the reaction shown below. Assume that the acetone and benzophenone are in solution together,then base is added.H3CCH3NaOHH3O+EtOH, heatacetonebenzophenonea. (1 point) Predict the crossed aldol product. Write the product in the boxb. (1 point) If the concentration of the acetone was doubled, what is a potential undesired outcome?c. (1 point) If the order of addition was acetone, NaOH, then benzophenone, what is a potential undesiredoutcome?

1.H3C-C(OH)=CH-C6H5-CO-CH3 B.Doubling the concentration of acetone may lead to an increase in…

Answered: 4. (3 points) Consider the reaction…

Organic Chemistry: A Guided Inquiry

2nd Edition

ISBN:9780618974122

Author:Andrei Straumanis

Publisher:Andrei Straumanis

Chapter13: Substitution

Section: Chapter Questions

Problem 40CTQ

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At step 4 in the mechanism of structure 5, at what does the arrow point?
How different would step 4 be if the amine was secondary? Show curved arrows and explain the mechanism!
Give the product of the aldol condensation in Figure 3
For the third step of the first reaction why is there a ch2-ch3 group connected to the epoxide, shouldn't there just be a ch3 group connected to it?
Write structures for the carbonyl electrophile and enolate nucleophile that react to give the aldol below. You do not have to consider stereochemistry. Draw the enolate nucleophile in its carbanion form. Draw one structure per sketcher. Add additional sketchers using the drop-down menu in the bottom right corner. Separate multiple reactants using the + sign from the drop-down menu.
how do i know if my aldol condensation is E or Z with the help of IR and NMR? what peaks should i be looking at? also, can someone give me a example of how to calculate the percent yield for aldol condensation?
It will be helpful if I find the distinction between these two products since they are both Elimination reactions? Will one proceed via E1 or E2? If so, why is that the case?
From each pair, select the stronger nucleophile. Q.)Cl2 or I2 in methanol
1. what is the Nature of the leaving group (LG)? 2. what is the relative size of activation energy (Ea) for each reaction? 3. what is the Hammond's postulate? 4. what are the Relative thermodynamic stability of the reactive intermediates? 5. what is Influence of the solvent (if given) on the reactions and intermediates?
Why we need step 3 before step 4? a. Because the nitro group increases the electrophilicity at the ortho positions which is where the bromine is added. b. Because the amine group is a strong ortho, para director which is what controls the regiochemical outcome of this bromination. c. Step 4 is unessesary. The symmetry of compound 3 allows for the bromination to be regioselective and give compound 5. 5. There will be a mixture of products because there is no selectivity for a major product.
Self-condensation of acetone is a possible side reaction for the aldol condensation(Reaction 1). Draw the structure of this side product. How is this side reaction minimizedin our procedure written below? Reaction 1 - Experimental Procedure: In a clean, small Erlenmeyer flask, combine your unknownaromatic aldehyde (350 μL (400 mg if it is a solid)), 95% ethanol (2.0 mL), and 5 N aqueoussodium hydroxide (0.6 mL). Swirl to mix, and then add acetone (100 μL). Stir/swirl vigorously for30 minutes, until precipitation is complete. If no precipitate forms after 15 minutes, heat theErlenmeyer flask gently in on the sand bath in the hood for 15 minutes, and then allow it to coolto room temperature. Whether heated or not, cool your Erlenmeyer flask in an ice bath for 10minutes to ensure complete crystallization. Collect the product by vacuum filtration. (If you donot have any solid at this point, evaporate all solvent in the sand bath. Recrystallize if solidresidue is obtained; otherwise stop…
1. Discuss the role of the Aldol condensation reaction in the synthesis below. What specific reaction was used in the synthesis? What is the importance of the aldol reaction in the entire synthetic approach? 2. Show the detailed reaction mechanism involved in their corresponding specific parts in this syntheses.

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