A 60-year-old man presents with a skin lesion on his face, which has been increasing in size for the past 6 months. He has been a farmer by occupation. His past medical history is unremarkable. A biopsy of the lesion shows nests of atypical deeply basophilic cells extending from the overlying epidermis into the papillary dermis. The nests show peripheral palisading of the cells with haphazard arrangement in the center. Which of the following descriptions of gross appearance corelate to the microscopic findings seen in this lesion? Answers A - E A Pearly nodule with telangiectasia B Purple, pruritic, and polygonal lesion C Rough sandpaper consistency lesion D Round flat, coin like waxy plaque E Salmon colored plaque with silvery white scales O
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- A 35 year-old half Filipino-half Pakistan presented to the outpatient department of dermatology at the hospital, with chief complaints of numerous hyperpigmented lesions on the proximal arms and on the upper back of approximately 5 months’ duration. The lesions become so itchy with the change of weather or when the affected parts got sweating. There was no other cutaneous or systemic complaints. His past health was unremarkable. The physical examination revealed numerous sharply demarcated brownish macules and patches on the arms and back. The size of the lesions ranged 3- 6 mm in diameter. Under the wood lamp examination, some of the lesions fluoresced into yellowish gold. What can be done to treat and avoid the recurrence of the disease? Based on the clinical appearance of the lesions, what diagnosis can you infer? This is caused by what organism?A 35 year-old half Filipino-half Pakistan presented to the outpatient department of dermatology at the hospital, with chief complaints of numerous hyperpigmented lesions on the proximal arms and on the upper back of approximately 5 months’ duration. The lesions become so itchy with the change of weather or when the affected parts got sweating. There was no other cutaneous or systemic complaints. His past health was unremarkable. The physical examination revealed numerous sharply demarcated brownish macules and patches on the arms and back. The size of the lesions ranged 3- 6 mm in diameter. Under the wood lamp examination, some of the lesions fluoresced into yellowish gold. What causes the hyperpigmentation of the lesions? If the scrapings from lesions will be tested for 10% KOH, what pattern or appearance can be seen under the microscope?This 19-year-old college student went to the Student Health Services because she had a slowly developing rash on both earlobes, hands and wrist, and around her neck. Her medical history revealed that she had eczema in childhood. During her early teens, she had facial acne, for which she was given tetracycline. Physical examination revealed a rash of erythema and small blisters, with marked excoriation because of the itching. Her hands were red, scaly, and dry. The rash on her hands was different from the eruptions on her neck and ears. A contact hypersensitivity was suspected. Follow-up patch tests included a standard battery of agents—rubber, cosmetics, plant extracts, perfumes, nickel, and makeup. Strongly positive reactions for rubber and nickel were observed. The student was advised to eliminate contact with rubber (e.g., rubber gloves) used at home or on the job. Her jewelry probably contained nickel and was believed to be the source of the irritation to her earlobes, neck, and…
- A 17-year-old boy presents to his pediatrician for evaluation of a rash in his genital area. He reports that it is very itchy and started about 1 week ago. At school, he participates in multiple sports, including wrestling with practice 3 times a week. He admits that he does not always wash his hands and often delays showering after practice. Physical examination reveals a red, scaly rash as shown in the attached image. Which of the following is the most likely cause of the rash? Answers A - E A Eikenella corrodens B Malassezia furfur C Mycobacterium marinum D Sporothrix schenckii E Trichophyton rubrum O O Question #22 attachment oA 17-year-old boy presents to his pediatrician for evaluation of a rash in his genital area. He reports that it is very itchy and started about 1 week ago. At school, he participates in multiple sports, including wrestling with practice 3 times a week. He admits that he does not always wash his hands and often delays showering after practice. Physical examination reveals a red, scaly rash as shown in the attached image. Which of the following is the most likely cause of the rash? Answers A - E A Eikenella corrodens B Malassezia furfur C Mycobacterium marinum D Sporothrix schenckii E Trichophyton rubrum O O O OA 35 year old half Filipino- half Pakistan presented to the outpatient department of dermatology at CVMC, with chief complaints of numerous hyperpigmented lesions on the proximal arms and on the upper back of approximately 5 months’ duration. The lesions become so itchy with the change of weather or when the affected parts got sweating. There was no other cutaneous or systemic complaints. His past health was unremarkable. The physical examination revealed numerous sharply demarcated brownish macules and patches on the arms and back. The size of the lesions ranged 3- 6 mm in diameter. Under the wood lamp examination, some of the lesions fluoresced into yellowish gold. Questions: Based on the clinical appearance of the lesions, what diagnosis can you infer? This is caused by what organism? If the scrapings from lesions will be tested for 10% KOH, what pattern or appearance can be seen under the microscope? What causes the hyperpigmentation of the lesions? What can be done to treat and…
- The inflammatory lesion that is described as a raised collection of pus is ___. A classic example is an acne pimple.Three-week-old Xavier Capelleto was brought to the emergency room with a bright scaly rash that first developed on his legs and then spread to his trunk and face. He also had blisters on his palms and the soles of his feet. Xavier’s parents said that he had been experiencing looser bowel movements than expected, a large amount of yellow pus had been accumulating around his swollen eyelids, and he showed signs of oral thrush. Tests revealed that Xavier’s lymphocyte count was only 8% of total white blood cells (normal = 50%), all immunoglobulins were markedly decreased except for IgE, and no thymic shadow was detected on a chest X-ray. Eosinophilia was also detected. His parents were told that Xavier had an autosomal recessive form of severe combined immunodeficiency (SCID) known as Omenn syndrome, which affects the development of both B cells and T cells. A bone marrow transplant was recommended; however, Xavier died from respiratory failure due to an opportunistic bacterial infection.…A 43-year-old man who recently started working in a wool processing factory presents with a pustule on his right forearm that developed 4 days ago. He says that he often forgets to wear his gloves while working. This morning he noticed that the pustule had ulcerated and turned black. A photograph of the lesion is shown. Which of the following is a characteristic of the most likely causative agent of this patient's skin lesion? Answers A - E A Anaerobic growth B Converts fibrinogen to fibrin C Establish latency in ganglia D Poly D-glutamate capsule E Production of blue-green pigment Question #27 attachment C
- A 31-year-old man presented with slowly spreading hyperpigmented and crusted lesions with the largest measuring 3 cm x 4 cm. The lesion started from the right sole of the foot and spread diffusely through the left ankle. He did not have similar lesions in the past, and there is no significant history of any chronic illness in the past. Upon examining his skin biopsy samples, the histopathological examination results showed: a. Pseudoepitheliomatous epidermal hyperplasia with the presence of pigmented spores arranged singly and in chains with peripheral neutrophil infiltration.b. Ziehl- Neelson staning negativec. PAS positived. Pus and granules negativee. Presence of granulomas along with golden- brown, thick- walled, spherical bodies about 5 to 8 μm in size. Questions: What disease can you infer from the results that are shown? Why have you said so? The case presented can be mistaken for what skin cancer? Why? What treatment is best to be given? What protective measures can be done to…An American tourist was brought to the Emergency Room because of an alarming serpiginous track on his arm. The lesions itched continuously, and were painful to touch. He had just returned from holiday where he spent considerable period relaxing on public beaches, and had observed stray dogs on the beach. Photograph of forearm showing serpiginous lesions. a. What is the diagnosis ? b. How is this infection acquired? c. What therapy is appropriate? d. Why are dogs and cats not permitted on beaches in resort areas?Mr. Samara Austin, a twenty-four-year footballer sustained a bruise on his right knee during training on the field and reported 3 days later with redness and oedema on the site. Explain the inflammatory process leading to the manifestations.