An over-the-counter (OTC) drug product needs to be analyzed to determine if it is adulterated (i.e., does not contain the active ingredient claimed on the product label and/or does not contain the amount of active ingredient claimed on the product label). The product is a simple mixture of ingredients that are water soluble. The active ingredient is non-volatile and has a max at 280 nm and emits light at 360 nm. The other ingredients in the product absorb light at 280 nm but do not emit light. Select the most appropriate analysis technique based on the information provided. a) HPLC with absorbance detection b) fluorescence spectroscopy c) absorbance spectroscopy d) HPLC with fluorescence detection
An over-the-counter (OTC) drug product needs to be analyzed to determine if it is adulterated (i.e., does not contain the active ingredient claimed on the product label and/or does not contain the amount of active ingredient claimed on the product label). The product is a simple mixture of ingredients that are water soluble. The active ingredient is non-volatile and has a max at 280 nm and emits light at 360 nm. The other ingredients in the product absorb light at 280 nm but do not emit light. Select the most appropriate analysis technique based on the information provided.
a) HPLC with absorbance detection
b) fluorescence spectroscopy
c) absorbance spectroscopy
d) HPLC with fluorescence detection
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