does electron withdrawing group prevent acylation       If I want to add a meta substituent in acylation, What steps do I need to take

Organic Chemistry: A Guided Inquiry
2nd Edition
ISBN:9780618974122
Author:Andrei Straumanis
Publisher:Andrei Straumanis
Chapter24: Carboxylic Acids & Derivatives
Section: Chapter Questions
Problem 12CTQ
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does electron withdrawing group prevent acylation

 

 

 

If I want to add a meta substituent in acylation, What steps do I need to take? Show the mechanism

Friedel- Crafts alkylation
R-CI
AICIBERC
R
3 3₂ ·catalyst (or FeX3)
RX is an alkyl halide. X = C or Br
AICI 3
+ Ha
Friedel- Crafts Acylation
&
acid
chloride
R
+ HC
z catalyst (or FeX3)
Transcribed Image Text:Friedel- Crafts alkylation R-CI AICIBERC R 3 3₂ ·catalyst (or FeX3) RX is an alkyl halide. X = C or Br AICI 3 + Ha Friedel- Crafts Acylation & acid chloride R + HC z catalyst (or FeX3)
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