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Each compound was tested for its ability to inhibit fatty acid synthase activity in both normal cells and breast cancer cells. ID50 values (the inhibitor concentration required to inhibit cell growth by 50%) are shown in the table. Which inhibitors are most effective? Compound Alkyl side chain (R) Breast cancer cells ID50 (µg/mL) Normal cells ID50 (µg/mL) A −−C13H27 3.9 10.6 B −−C11H23 4.8 29.0 C −−C8H17 5.0 21.3 D −−C6H13 8.4 12.4

Each compound was tested for its ability to inhibit fatty acid synthase activity in both normal cells and breast cancer cells. ID50 values (the inhibitor concentration required to inhibit cell growth by 50%) are shown in the table. Which inhibitors are most effective? Compound Alkyl side chain (R) Breast cancer cells ID50 (µg/mL) Normal cells ID50 (µg/mL) A −−C13H27 3.9 10.6 B −−C11H23 4.8 29.0 C −−C8H17 5.0 21.3 D −−C6H13 8.4 12.4

Introduction to General, Organic and Biochemistry
Introduction to General, Organic and Biochemistry
11th Edition
ISBN:9781285869759
Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Publisher:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar Torres
Chapter31: Immunochemistry
Section: Chapter Questions
Problem 31.72P
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Each compound was tested for its ability to inhibit fatty acid synthase activity in both normal cells and breast cancer cells. ID50 values (the inhibitor concentration required to inhibit cell growth by 50%) are shown in the table. Which inhibitors are most effective?

Compound Alkyl side chain (R) Breast cancer cells
ID50 (µg/mL)		 Normal cells
ID50 (µg/mL)
A −−C13H27 3.9 10.6
B −−C11H23 4.8 29.0
C −−C8H17 5.0 21.3
D −−C6H13 8.4 12.4

 

 

 

Compound D

Compound C

Compound A

Compound B 

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