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GPCR in the presence of one of these compounds. 0.5 0-0-0 0 A B ***** C 300-00 D 100 0.001 0.01 0.1 1 10 100 1000 A. Compounds A are full or almost full agonists. B. Compound B is a partial agonist. active receptor,

GPCR in the presence of one of these compounds. 0.5 0-0-0 0 A B ***** C 300-00 D 100 0.001 0.01 0.1 1 10 100 1000 A. Compounds A are full or almost full agonists. B. Compound B is a partial agonist. active receptor,

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Please explain this question and make me understand why D is the answer.
31. Investigation of a family of related compounds of a promising GPCR drug target showed a range of activities that could be grouped into four categories (A-D) differing in their mode of action. Select the FALSE statement based on the dose-ressponse curves obtained for GPCR in the presence of one of these compounds. 0.5 0 A B C 0.001 0.01 0.1 1 10 100 1000 D A. Compounds A are full or almost full agonists. Compound B is a partial agonist. B. C. The studied GPCR is a constitutively active receptor. D. Compound C shows no effect, hence it is an antagonist. E. Compounds D are inverse agonists with varying degree of efficacy.
Transcribed Image Text:31. Investigation of a family of related compounds of a promising GPCR drug target showed a range of activities that could be grouped into four categories (A-D) differing in their mode of action. Select the FALSE statement based on the dose-ressponse curves obtained for GPCR in the presence of one of these compounds. 0.5 0 A B C 0.001 0.01 0.1 1 10 100 1000 D A. Compounds A are full or almost full agonists. Compound B is a partial agonist. B. C. The studied GPCR is a constitutively active receptor. D. Compound C shows no effect, hence it is an antagonist. E. Compounds D are inverse agonists with varying degree of efficacy.
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