Imagine you are studying the genetic basis of gout using GWAS and have available molecular markers (single nucleotide polymorphism tags or SNP tags) located all over the genome. Your results are displayed below. -log, P-value 30 25 8 15 10- 5 ABCG2 I SLC2A9 ī Chromosome MYL2-CUX2 i O 11 12 13 14 15 16 17 18 19202122 a) From the plot above. Which chromosome/s would be the focus of your future studies in search of the genes that might be responsible for gout? Chromosome/s b) Briefly justify your choice/s for item a: I choose those chromosomes because c) You have made some assumptions to answer the previous item, please share them by filling in the blanks below: i) I am interpreting the results as: most of the patients that show gout symptoms also show allele/s for the SNP tag on chromosomes different alleles for the SNP tags on the other chromosomes. (the same/different) (please supply chormosome/s number/s as above), but an array of ii) My assumption about the relationship between gene distance (distance between the SNP tag and the candidate genes proposed as potential disease genes) and linkage disequilibrium (LD) is that the smaller the distance, the (higher/lower) the LD. iii) My assumption about the relationship between recombination rate and LD is that the higher the recombination rate, the (higher/lower) the LD.
Imagine you are studying the genetic basis of gout using GWAS and have available molecular markers (single nucleotide polymorphism tags or SNP tags) located all over the genome. Your results are displayed below. -log, P-value 30 25 8 15 10- 5 ABCG2 I SLC2A9 ī Chromosome MYL2-CUX2 i O 11 12 13 14 15 16 17 18 19202122 a) From the plot above. Which chromosome/s would be the focus of your future studies in search of the genes that might be responsible for gout? Chromosome/s b) Briefly justify your choice/s for item a: I choose those chromosomes because c) You have made some assumptions to answer the previous item, please share them by filling in the blanks below: i) I am interpreting the results as: most of the patients that show gout symptoms also show allele/s for the SNP tag on chromosomes different alleles for the SNP tags on the other chromosomes. (the same/different) (please supply chormosome/s number/s as above), but an array of ii) My assumption about the relationship between gene distance (distance between the SNP tag and the candidate genes proposed as potential disease genes) and linkage disequilibrium (LD) is that the smaller the distance, the (higher/lower) the LD. iii) My assumption about the relationship between recombination rate and LD is that the higher the recombination rate, the (higher/lower) the LD.
Human Anatomy & Physiology (11th Edition)
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please complete part C
Transcribed Image Text:Imagine you are studying the genetic basis of gout using GWAS and have available molecular markers (single nucleotide polymorphism tags
or SNP tags) located all over the genome. Your results are displayed below.
-log, P-value
30
25
20
15
10
10
ABCG2
1
SLC2A9
And n
Chromosome
MYL2-CUX2
9 10 11 12 13 14 15 16 17 18 19202122
a) From the plot above. Which chromosome/s would be the focus of your future studies in search of the genes that might be responsible for
gout? Chromosome/s
b) Briefly justify your choice/s for item a: I choose those chromosomes because
c) You have made some assumptions to answer the previous item, please share them by filling in the blanks below:
i) I am interpreting the results as: most of the patients that show gout symptoms also show
allele/s for the SNP tag on chromosomes
different alleles for the SNP tags on the other chromosomes.
(the same/different)
(please supply chormosome/s number/s as above), but an array of
ii) My assumption about the relationship between gene distance (distance between the SNP tag and the candidate genes proposed as
potential disease genes) and linkage disequilibrium (LD) is that the smaller the distance, the (higher/lower)
the LD.
iii) My assumption about the relationship between recombination rate and LD is that the higher the recombination rate, the (higher/lower)
the LD.
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