In the attached image shows the charge in concentration of caspase 3 and 9 in cells of two different cancer cell lines following exposure to concentrations of the drug bafilomycin A1. -Describe the effect of Bafilomycin A1 on caspase 3 and caspase 9 in the cell lines. -Based on the above, what would you expect to happen to cells exposed to Bafilomycin A1?
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Bafilomycin A1
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Caspase-3
Caspase-9
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caspase activation](/v2/_next/image?url=https%3A%2F%2Fcontent.bartleby.com%2Fqna-images%2Fquestion%2Fc210d48c-29a4-4c3d-bd6e-a8e98c74e2b1%2Fcf032510-7868-4a2e-bf21-e4cb28d955ae%2F4zc0e4_processed.jpeg&w=3840&q=75)
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based on the above graph, what would you expect to happen to cells exposed to bafilomycin A1? Justify your answer.
- Please give a mathematical explanation of the signs(positive or negative) of beta1, beta2, and beta3.please help me out. show full working out for better understanding Hereditary hemochromatosis (HH) is a recessively inherited genetic disorder resulting from mutations in the HFE gene. There are several possible mutations of different degrees of importance but the disease expresses itself only when at least 2 arepresent in any one individual. A blood analysis was performed on 3,000 blood samples from newborn babies of Caucasian descent in the state of Michigan, USA. The results showed that 163 of those sampled carried two mutations in the HFE gene. a. What is the proportion in the sample that carry the two mutations of the HFE gene? b. Calculate the 95% confidence interval for the proportion of this population that carries two mutations in the HFE Check the data for the necessary conditions and show full working. c. Interpret your interval in context d. If the researcher wanted to halve (x ½) the margin of error in the confidence interval found, what sample size would be required…Q4; Some of the results of a trial, carried out by the Department of Pharmacology/ Thi-Qar College of Medicine in 2010, of a new antihypertensive drug and methyldopa are shown below. Each patient received each treatment for a period of 8 weeks separated by a period of wash out on placebo. Change in systolic blood pressure Methyldopa + 10 + 08 - 33 + 19 + 31 Patient New drug - 10 - 09 + 04 + 04 + 04 1. 2. 3. 4. 5. 6. -30 12 7. 00 28 - 02 + 03 - 28 - 21 8. %3D 9. 10. 14 06 De these date show that any of these two drugs have a greater effect than the other?
- Age Male Females 21 0.001420 0.000472 22 0.001488 0.000487 23 0.001502 0.000496 24 0.001474 0.000503 25 0.001430 0.000509 26 0.001393 0.000519 27 0.001366 0.000535 28 0.001362 0.000561 29 0.001379 0.000595 30 0.001406 0.000637 A- a 23 year old female pays $275 for 1-year $150,000 life insurance policy. what is the expected value of the policy fo the policyholder? B- a 23 year old female pays $275 for 1-year $150000.00 life insurane policy what is the expected value of the policy for the insurance company?6 A study was conducted that measured the total brain volume (TBV) (in mm3) of patients that had schizophrenia and patients that are considered normal. Table #1 contains the TBV of the normal patients and Table #2 contains the TBV of schizophrenia patients ("SOCR data Oct2009," 2013). Table #1: Total Brain Volume (in mm3) of Normal Patients 1663407 1583940 1299470 1535137 1431890 1578698 1453510 1650348 1288971 1366346 1326402 1503005 1474790 1317156 1441045 1463498 1650207 1523045 1441636 1432033 1420416 1480171 1360810 1410213 1574808 1502702 1203344 1319737 1688990 1292641 1512571 1635918 Table #2: Total Brain Volume (in mm3) of Schizophrenia Patients 1331777 1487886 1066075 1297327 1499983 1861991 1368378 1476891 1443775 1337827 1658258 1588132 1690182 1569413 1177002 1387893 1483763 1688950 1563593 1317885 1420249 1363859 1238979…X ASSIGNMENT QUIZ II (page 3 of x O Meet - ajz-fvxm-hnq X (no subject) - 13683703@uofn.ec M moodle.unizwa.edu.om/mod/quiz/attempt.php?attempt=96478&cmid%=315478&page=D2 A A Home e Dashboard My courses - A This course - Colleges Software Guides Search Contact us Quiz navigation Time left 0:24:19 1 2 4 5 6. Question 3 Gis Klein's 4-group3{e,a,b,c}, H =, then [G:H] is Not yet answered Finish attempt . Marked out of O 3 2.00 O 4 P Flag question O 1 O 2 O None of them Previous page Next page https://moodle.unizwa.edu.om/mod/quiz/attempt.php?attempt=96478&cmid=31547&page=2# uo Il:-1 م اكتب هنا ل لبحث ) e
- The genetic of a human is the source of a disese., but only if you have the gene type a. The relative frequency of people with carrying two copies of a is 0.0001(aa), but one copy is 0.0198(Aa). Those not having the a-gene = 0.9801(AA) Even though you are carrying a you may not get the disese. You can get the disese without a. the probability of aa = 0.6, Aa= 0.02 and AA= 0.01 What is the probability that a random person has the disese? Given you have the disese, whats the probabilty for having genes aa, Aa or AA?dep=2742 7688tags=Dautosave#question4737388_1 It is well known that a placebo, a fake medication or treatment, can sometimes have a positive effect just because patients often expect the medication or treatment to be helpful. An article gave examples of a less familiar phenomenon, the tendency for patients informed of possible side effects to actually experience those side effects. The article cited a study in which a group of patients diagnosed with benign prostatic hyperplasia is randomly divided into two subgroups. One subgroup of size 60 received a compound of proven efficacy along with counseling that a potential side effect of the treatment is erectile dysfunction. The other subgroup of size 50 is given the same treatment without counseling. The percentage of the no- counseling subgroup that reported one or more sexual side effects is 16%, whereas 40% of the counseling subgroup reported at least one sexual side effect. State and test the appropriate hypotheses at significance…Dogwood trees - Researchers studying dogwood trees found that 89% of the dogwood trees of a standard strain die within three years of planting in a particular industrial area. Martin, a researcher at a nearby university, is currently studying a new strain of dogwood tree, believed to be resistant to air pollution. In an initial phase of the study, Martin found that 50 seedlings of the new strain were planted in the area and 42 (84%) of them died in three years. 1. Martin wants to know it the new strain of dogwood tree is more resistant to air pollution than the standard strain. He formulates the following null hypothesis: The percentage of the new strain dogwood trees that die within three years is 89%, the same as the standard strain. What is the appropriate alternate hypothesis? OA. HA The percentage of new strain dogwood trees that die within three years is less than 89%. OB. HA The percentage of new strain dogwood trees that die within three years is more than 89%. OC. HA The…
- A physiologist believes he has discovered a new steroid hormone that can affect the blood glucose in reptiles. In an experiment he injects turtles with a small amount of this steroid hormone and, after a suitable waiting period measures the blood glucose level of the turtles. In his sixteen experimental turtles he obtains the following levels of blood glucose {2, 1, 3, 5, 2, 1, 1, 5, 3, 2, 1, 1, 2, 1, 1, 5}. From previous studies of thousandsof normal, un-manipulated turtles he knows that the mean (μ) blood glucose level in this species of turtle (his laboratory population) is 3. Evaluate the hypothesis that this new steroid hormone affects blood glucose levels. Use an α-level of 0.01 for this analysis. A) What is the appropriate test? B) State the null hypothesis: C) State the alternative hypothesis: D) Find the critical value: E) Calculate the obtained statistic: F) Make a decision: G) What does your decision mean? Please explain how you got the answers Thank youA physiologist believes he has discovered a new steroid hormone that can affect the blood glucose in reptiles. In an experiment he injects turtles with a small amount of this steroid hormone and, after a suitable waiting period measures the blood glucose level of the turtles. In his sixteen experimental turtles he obtains the following levels of blood glucose {2, 1, 3, 5, 2, 1, 1, 5, 3, 2, 1, 1, 2, 1, 1, 5}. From previous studies of thousandsof normal, un-manipulated turtles he knows that the mean (μ) blood glucose level in this species of turtle (his laboratory population) is 3. Evaluate the hypothesis that this new steroid hormone affects blood glucose levels. Use an α-level of 0.01 for this analysis. D) Find the critical value: E) Calculate the obtained statistic: F) Make a decision: G) What does your decision mean? Please show step-by-step how you solved each problem. In addition, please explain in words how you calculated the obtained statistic.Ophthalmology, Genetics Age-related macular degeneration (AMD) is a common eye disease among the elderly that can lead to partial or total loss of vision. It is well known that smoking and excessive weight tend to be associated with higher incidence rates of AMD. More recently, however, several genes have been found to be associated with AMD as well. One gene that has been considered is the Y402H gene (RS 1061170). There are three genotypes for the Y402H gene-TT, TC, and CC. Suppose the relationship between AMD and the Y402H genotype is as follows. Association between Y402H genotype and prevalence of AMD in a high-risk population Y402H TT (wild type) TC CC Total USE SALT AMD = yes 39 118 120 277 AMD = no 378 528 276 1,182 (a) What is the relative risk for AMD for the CC genotype compared with the TT genotype? (Round your answer to two decimal places.) (b) One issue is whether the Y402H gene is in Hardy-Weinberg equilibrium (HWE). For a gene to be in HWE, its two alleles must assort…