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Is the sickle cell allele dominant or recessive? Explain. What is sickle cell trait?
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- What is the frequency of sickle cell disease (anemia)? https://ghr.nlm.nih.gov/condition/sickle-cell-disease#inheritance https://www.cdc.gov/ncbddd/sicklecell/traits.htmlSickle-cell disease is an autosomal recessive genetic disorder. How many mutated hemoglobin alleles do people with sickle-cell disease have?What is sickle cell anemia? What is the true inheritance pattern? How did scientists discover the true inheritance pattern?
- Given the information regarding sickle cell anemia, if two carriers were to have children, what would be the genotypes and phenotypes of their children? Would any of the children show symptoms of the disease?Suppose a woman who is a carrier of sickle-cell trait (making her a heterozygote) has children with a man who is totally healthy and does not carry the gene for sickle-cell trait at all. Which one of the following is true about their potential children? (Draw a Punnett square on scratch paper if it helps you.) A) None of their children will have sickle-cell disease. B) All of their children will have sickle-cell disease. C) All of the couple's children would be heterozygous carriers like the mother.What advantage is there for individuals that are heterozygous for the sickle cell character?
- Sickle anemia is a favorable mutation. There is only one amino acid different in sickle haemoglobin (S) as compared with normal haemogloblin (A). Persons with sickle cell trait (AS) are able to survive in malarious areas. A couple each having sickle cell trait have five children. What is the probability that they will have a child with sickle disease?Explain the differences between an individual homozygous for the sickle hemoglobin allele (HbS/HbS) and one who is heterozygous (HbA/HbS). Consider the hemoglobin molecule, cells, and disease.Describe the phenotype of individuals who inherit two copies of the HbS allele-Sickle Cell Disease. ( find a source to support the information)