Match each of the following descriptions to the type of regulatory RNA affecting a "target" gene (aka, the gene the regulatory RNA is regulating). Use each answer once. This regulatory RNA may increase siRNA transcription of the target gene by recruiting activator proteins. secondary structures on RNA can become... IncRNA these regulatory RNAs regulate gene miRNA expression post transcriptionally generally by binding to the 3'-UTR regions of their target RNAs > >

Match each of the following descriptions to the type of regulatory RNA affecting a "target" gene (aka, the gene the regulatory RNA is regulating). Use each answer once. This regulatory RNA may increase siRNA transcription of the target gene by recruiting activator proteins. secondary structures on RNA can become... IncRNA these regulatory RNAs regulate gene miRNA expression post transcriptionally generally by binding to the 3'-UTR regions of their target RNAs > >

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter10: From Proteins To Phenotypes

Section: Chapter Questions

Problem 21QP: Transcriptional regulators are proteins that bind to promoters (the 5-flanking regions of genes) to...

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Similar questions

Through alternative splicing, eukaryotes (a) reinforce gene inactivation (b) prevent transcription of heterochromatin (c) produce related but different proteins in different tissues (d) amplify genes to meet the requirement of high levels of a gene product (e) bind transcription factors to enhancers to activate transcription
You have isolated a protein that binds to DNA in theregion upstream of the promoter sequence of the sysgene. If this protein is a positive regulator, which ofthe following would be true?a. Loss-of-function mutations in the gene encodingthe DNA-binding protein would cause constitutiveexpression of sys.b. Loss-of-function mutations in the gene encodingthe DNA-binding protein would result in little orno expression of sys.
A cloned gene fragment contains a regulatory element that isrecognized by a regulatory transcription factor. Previousexperiments have shown that the presence of a hormone resultsin transcriptional activation by this transcription factor. To studythis effect, you conduct an electrophoretic mobility shift assayand obtain the following results: Explain the action of the hormone.
A. Identify the mutation(s) that lead to the most loss in transcriptional activity, and discusswhether those match expectations based on the consensus sequence for the Initiator.B. Hypothesize a molecular mechanism to explain how the mutations identified in Part Aresult in loss of transcription activity.C. Identify whether any mutations cause transcription to initiate from a different positionthan wild-type, and provide a brief explanation as to why that occurs for those mutantcore promoters. THIS IS A PRIMER EXTENSION ASSAY
The hunchback gene contains a 5′ transcriptional regulatory region, a 5′ UTR, a structural region (the coding sequences), and a 3′ UTR.a. What important sequences required to controlhunchback gene expression are found in the transcriptional regulatory region of hunchback?b. What sequence elements that encode specific protein domains are found in the structural region ofhunchback?c. Another important kind of sequence is located inthe 3′ UTR of the hunchback mRNA. What mightthis sequence do?
Mechanisms that inhibit TE activity include theproduction of transposition repressors throughalternative splicing and the action of _________ thatblock TE transcription.
Mutations in bacterial promoters may increase or decrease therate of gene transcription. Promoter mutations that increasetranscription are termed up-promoter mutations, and those thatdecrease transcription are termed down-promoter mutations.The sequence of the −10 site of the promoter for the lac operonis TATGTT (see Figure 14.5). Would you expect each of thefollowing mutations to be an up-promoter or down-promotermutation?A. TATGTT to TATATTB. TATGTT to TTTGTTC. TATGTT to TATGAT
Define the following terms:a. cohesinb. transcription factoryc. P bodiesd. CTCFe. ENCODE
Explain why RNAi would be a less effi cient mechanism for regulating the expression of specifi c genes if Dicer hydrolyzed double-stranded RNA every 11 bp rather than every 22 bp.
Some transcription regulators bind to DNA andcause the double helix to bend at a sharp angle. Such“bending proteins” can affect the initiation of transcrip-tion without directly contacting any other protein. Can youdevise a plausible explanation for how such proteins mightwork to modulate transcription? Draw a diagram that illus-trates your explanation.
. In an effort to determine the location of an operator sitefor a negatively regulated gene, you have made a seriesof deletions within the regulatory region. The extent ofeach deletion is shown by the line underneath the sequence, and the resulting expression from the operon(i = inducible; c = constitutive; − = no expression) isalso indicated.... GGAT C T T AGCCGGCTAACATGATAAATATAA......C C T AGAATCGGCCGA TTGTA C T A TTT ATAT T ...1 i2 –3 c4 –5 ca. What can you conclude from these data about thelocation of the operator site?b. Why do you think deletions 2 and 4 show no expression of the gene?
Define regulatory mutation. Describe how an insertion, deletion, or substituion of a base pair in a promoter might affect the transcription driven by that promoter.