There are a number of pharmacokinetic strategies available to change the absorption of a lead compound during the drug design process. (a) Based on the lead compound shown, draw an analogue which has decreased polarity using two different strategies. The drawing can be done neatly by hand or by using ChemDraw. (b) Clearly label your analogue with the strategy being used for each change. (c) State whether your analogue will be more hydrophillic or hydrophobic than the original lead compound shown. (d) Attach a clear photo of your handwritten structure and answers using an image file or upload a PDF, Powerpoint or Word file containing your ChemDraw structure and answers. Cl CH3

There are a number of pharmacokinetic strategies available to change the absorption of a lead compound during the drug design process. (a) Based on the lead compound shown, draw an analogue which has decreased polarity using two different strategies. The drawing can be done neatly by hand or by using ChemDraw. (b) Clearly label your analogue with the strategy being used for each change. (c) State whether your analogue will be more hydrophillic or hydrophobic than the original lead compound shown. (d) Attach a clear photo of your handwritten structure and answers using an image file or upload a PDF, Powerpoint or Word file containing your ChemDraw structure and answers. Cl CH3

Organic Chemistry

8th Edition

ISBN:9781305580350

Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Publisher:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. Foote

Chapter23: Amines

Section: Chapter Questions

Problem 23.21P

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