Theresa and John are thrilled to learn they are to be parents for the first time. Theresa goes in for her routine prenatal check-up and finds that her blood type is O-negative, but John has Rh-positive blood, so there is a chance that their child will be Rh-positive. For the following questions, assume that the fetus is Rh-positive. When will Theresa first be exposed to Rh antigens? Be specific. When will she produce anti-Rh antibodies? Be specific. Will her first child be affected by anti-Rh antibodies? Why or why not? If Theresa isn’t given an immunoglobulin shot (RhoGAM), can she and John safely have a second child? Why or why not? (Include HDN in your explanation). What is RhoGAM? How does it prevent Hemolytic Disease of the Newborn (HDN)?

Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN:9781305251052
Author:Michael Cummings
Publisher:Michael Cummings
Chapter17: Genes And The Immune System
Section: Chapter Questions
Problem 19QP
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  1. Theresa and John are thrilled to learn they are to be parents for the first time. Theresa goes in for her routine prenatal check-up and finds that her blood type is O-negative, but John has Rh-positive blood, so there is a chance that their child will be Rh-positive. For the following questions, assume that the fetus is Rh-positive.
  2. When will Theresa first be exposed to Rh antigens? Be specific.
  3. When will she produce anti-Rh antibodies? Be specific.
  4. Will her first child be affected by anti-Rh antibodies? Why or why not?
  5. If Theresa isn’t given an immunoglobulin shot (RhoGAM), can she and John safely have a second child? Why or why not? (Include HDN in your explanation).
  6. What is RhoGAM? How does it prevent Hemolytic Disease of the Newborn (HDN)?
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