Tumour associated macrophages (TAMS) represent up to 50% of cells in solid tumours. Explain how these cells contribute to immunosuppression in the tumour microenvironment and how they help tumour cells to evade anti-tumour immune responses

Tumour associated macrophages (TAMS) represent up to 50% of cells in solid tumours. Explain how these cells contribute to immunosuppression in the tumour microenvironment and how they help tumour cells to evade anti-tumour immune responses

Human Heredity: Principles and Issues (MindTap Course List)

11th Edition

ISBN:9781305251052

Author:Michael Cummings

Publisher:Michael Cummings

Chapter17: Genes And The Immune System

Section: Chapter Questions

Problem 8QP: The Adaptive Immune Response Is a Specific Defense Against Infection Identify the components of...

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Concept explainers

Immunology

Immunology is the division of science involved with the immune reactions occurring in living organisms. The organisms are accustomed to evolving internal defense mechanisms to evade the invasion of microbial pathogens. Diverse cells are connected with stimulating the immune responses, which produce inhospitable conditions to the microbes prompting their lysis and thus inhibits the multiplication of the pathogens. The immune system can distinguish the pathogens through the aid of cellular intercommunication and launch responses to destroy them.

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Tumour associated macrophages (TAMS) represent up to 50% of cells in
solid tumours. Explain how these cells contribute to immunosuppression
in the tumour microenvironment and how they help tumour cells to evade
anti-tumour immune responses

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