Upon antigen exposure, antigen binding sites;. is the first antibody produced with is the second antibody produced with antigen binding sites, and the is the last antibody produced, which is most specific and has antigen binding sites O IgM; 10; IgA; 4; IgG; 2 O IgM; 10; IgD; 4; IgA; 2 IgM: 2; IgA: 2; IgG: 2 O IgG; 2; IgE; 4: IgM: 10
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- Which of the following is not a part of innate immunity? a. phagocytic cells e. inflammation b. fever f. complement activation c. histamines g. presenting antigen d. cytokines h. all take partMultiple Matching. Place all possible matches in the spaces at theleft of each Ig.__________IgG__________IgA__________IgD__________IgE__________IgM a. found in mucous secretionsb. a monomerc. a dimerd. has greatest number of Fabse. first antibody made duringthe primary response f. first antibody made duringthe secondary responseg. crosses the placentah. fixes complementi. involved in allergic reactionsj. primarily a surface receptoron B cells1.A given B cell expresses only maternally or paternally derived heavy chains but never both. This observation is the result of A. antibodydiversity.B. isotypeswitching.C. allelicexclusion.D. affinitymaturation.E. randomVJgenerearrangement. 2.Which of the following antibody classes or isotypes facilitate the sequential binding of the C1, C4, C2, and C3 components of the complement system? A. IgAandIgD B. IgAandIgE C. IgDandIgM D. IgE and IgG E. IgMandIgG
- Know the major characteristics of the different antibodies (Ab's) Ex. bivalent, highest concentration Ab in blood, allows for phagocytosis, can cross the placenta, small (good in extravascular areas)i. Draw a schematic diagram of a typical IgG molecule and label each of the following parts: H chains, L chains, intrachain disulfide bonds, hinge, Fab, Fc, and all the domains. Indicate which domains are involved in antigen binding.A 24 year old previously healthy woman is evaluated for skin rash, joint pains, and renal failure. Sheis found to have decreased C3 and C4 levels and a normal factor B level. Which of the following most likely triggered the complement systemactivation in this patient? (A) Antigens binding to igA (B) Autoactivation of C3 component (C) C1 components binding to C1 inhibitor (D) C9- Lipid membrane complex formation (E)IgG antigen complex formation
- Why must antibody treatments like ZMapp be composed of monoclonal antibodies instead of polyclonal antibodies? a. Therapeutic antibodies must all bind the same epitope. b. Therapeutic antibodies must NOT all bind the same epitope. c. Monoclonal antibodies have much higher binding affinity than polyclonal antibodies. d. Monoclonal antibodies have much lower binding affinity than polyclonal antibodies. e. Monoclonal antibodies can be produced indefinitely; polyclonal antibodies can only be produced for a short time. IS it B? Can you please explainMaternal antibodies transmitted via the placenta: A. are an example of natural passive immunity B. are an example of natural active immunity C. are IgG antibodies D. both are IgG antibodies and are an example of natural active immunity E. both are IgG antibodies and are an example of natural passive immunityBased on the constant region of the antibodies there are only five iso-types of the antibodies, while millions of different “V” region domains in the variable part of the antibodies.
- A given B cell expresses only maternally or paternally derived heavy chains but never both. This observation is the result of A. antibodydiversity.B. isotypeswitching.C. allelicexclusion.D. affinitymaturation.E. randomVJgenerearrangement.Which of the following statements is NOT true of a fever?a. Temperature is regulated by chemicals that reset the body's thermostat to a higher setting.b. The higher than normal body temperature impairs the functions of some bacteria.c. The higher than normal body temperature is always harmful.d. The higher temperature impairs leukocytes andantibody production.e. Both c and d. Which of the following statements is NOT true of antibodies?a. They bind to foreign antigens, making them susceptible to being engulfed by phagocytes.b. They serve as specific binding sites on B cells.c. An antibody is usually able to bind to a variety of different types of antigensd. They are composed of two heavy chains and two light chains.Antibodies can have multiple mechanisms of action. The main mechanism is "flagging" a foreign body for phagocytosis and degradation. Another mechanism is... Select one: a. Binding of the Fc domain to T cells for cooperative antigen recognition and destruction. b. Altering the local pH by the formation of carbamate upon reaction with CO2 to denature protein antigens. c. Binding of the variable region to multiple different/distinct sites on the antigen. d. None of these. e. Binding of the antigen in regions essential for its function.
