Human Heredity: Principles and Issues (MindTap Course List)
11th Edition
ISBN: 9781305251052
Author: Michael Cummings
Publisher: Cengage Learning
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Chapter 10, Problem 4QP
Questions 4 through 6 refer to the following hypothetical pathway in which substance A is converted to substance C by enzymes 1 and 2. Substance B is the intermediate produced in this pathway:
a. If an individual is homozygous for a null mutation in the gene that codes for enzyme 1, what will the result be?
b. If an individual is homozygous for a null mutation in enzyme 2, what will the result be?
c. What if an individual is heterozygous for a dominant mutation in which enzyme 1 is overactive?
d. What if an individual is heterozygous for a mutation that abolishes the activity of enzyme 2 (a null mutation)?
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See the hypothetical pathway answer the following questions.
A) If an individual is homozygous for a null mutation in the gene that codes for Enz1, what would the result be?
B) What would happen if an individual is heterozygous for a mutation that abolishes the activity of Enz2?
C) What could happen to the offspring of the individuals described above (in a and b)? Assume that they only have the mutations described.
If Beadle and Tatum had found the results below in their experiment, which metabolic pathway would correspond to their findings? Fill in both the order of the substances as well as the order of the enzymes encoded by the genes that were mutated.
Mutation
Substance T
Substance W
Substance X
Substance Y
Substance Z
A
Growth
Growth
No growth
No growth
No growth
B
Growth
Growth
No growth
Growth
No growth
C
Growth
Growth
No growth
Growth
Growth
D
No growth
Growth
No growth
No growth
No growth
___ ___ ___ ___
_______ -------> _________ ------> ________ -----→ _________ ------→ _______
In a line of human cells grown in culture, a geneticist isolates a temperature-sensitive mutation at a locus that encodes an acetyltransferase enzyme; at temperatures above 38°C, the mutant cells produce a nonfunctional form of the enzyme. What would be the most likely effect of this mutation if the cells were grown at 40°C?
Chapter 10 Solutions
Human Heredity: Principles and Issues (MindTap Course List)
Ch. 10.4 - Prob. 1GRCh. 10.4 - Prob. 2GRCh. 10.7 - Prob. 1EGCh. 10.7 - Prob. 2EGCh. 10 - A couple was referred for genetic counseling...Ch. 10 - A couple was referred for genetic counseling...Ch. 10 - A couple was referred for genetic counseling...Ch. 10 - Many individuals with metabolic diseases are...Ch. 10 - Prob. 2QPCh. 10 - Enzymes have all the following characteristics...
Ch. 10 - Questions 4 through 6 refer to the following...Ch. 10 - Questions 4 through 6 refer to the following...Ch. 10 - Prob. 6QPCh. 10 - Prob. 7QPCh. 10 - Prob. 8QPCh. 10 - a. Compounds A, B, C, and D are known to be...Ch. 10 - b. Compounds A, B, C, and D are known to be...Ch. 10 - a. If an individual who is homozygous for the...Ch. 10 - Prob. 12QPCh. 10 - Suppose that in the formation of phenylalanine...Ch. 10 - If phenylalanine was not an essential amino acid,...Ch. 10 - Phenylketonuria and alkaptonuria are both...Ch. 10 - The normal enzyme required for converting sugars...Ch. 10 - Knowing that individuals who are homozygous for...Ch. 10 - Prob. 18QPCh. 10 - A person was found to have very low levels of...Ch. 10 - If an extra nucleotide is inserted in the first...Ch. 10 - Transcriptional regulators are proteins that bind...Ch. 10 - Prob. 22QPCh. 10 - Prob. 23QP
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