Organic Chemistry
7th Edition
ISBN: 9780321803221
Author: Paula Y. Bruice
Publisher: Prentice Hall
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Question
Chapter 24, Problem 27P
(a)
Interpretation Introduction
Interpretation:
Five enzymes required by alpha ketoglutarate that coverts alpha ketoglutarate to succinyl CoA has to be identified.
(b)
Interpretation Introduction
Interpretation:
The proposed mechanism for the reaction should be determined.
Concept introduction:
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Five coenzymes are required by alpha-ketoglutarate dehydrogenase, the enzyme in the citric acid cycle that converts a-ketoglutarate to succinyl-CoA. a. Identify the coenzymes. b. Propose a mechanism for the reaction
NADH
H*
NAD+
O=C
HČ-OH
ČH3
ČH3
Which is the electron acceptor in this lactate dehydrogenase reaction?
1. NAD+
2. NADH
3. L-lactate
4. Pyruvate
Explanation:
b) The metabolic pathway of warfarin is deficient since this patient is a
Warfarin is partially metabolised, most of it remaining in the bloodstream
of warfarin's therapeutic effect. g
5. The addition of glucuronic acid to a drug:
a. Decreases its water solubility
b. Leads to inactivation of the drug
C.
c. Is an example of a Phase I metabolism reaction
d. Occurs at the same rate in adults and new-borns
e. Involves cytochrome P450
Explanation:
b) The addition of glucuronic acid to a drug leads to an increase in its
enhances the inactivation and subsequently excretion of the drug. g
Chapter 24 Solutions
Organic Chemistry
Ch. 24.1 - Prob. 2PCh. 24.1 - Prob. 3PCh. 24.2 - How many conjugated double bonds are there in a....Ch. 24.2 - Instead of adding to the 4a position and...Ch. 24.2 - Prob. 7PCh. 24.3 - Prob. 8PCh. 24.3 - Acetolactate synthase is another TPP-requiring...Ch. 24.3 - Acetolactate synthase transfers the acyl group of...Ch. 24.5 - Prob. 12PCh. 24.5 - The enzyme that catalyzes the C C bond cleavage...
Ch. 24.5 - Propose a mechanism for the ,-elimination reaction...Ch. 24.5 - Which compound is more easily decarboxylated?Ch. 24.5 - Explain why the ability of PLP to catalyze an...Ch. 24.5 - Explain why the ability of PLP to catalyze an...Ch. 24.6 - Ethanolamine ammonia lyase, a coenzyme...Ch. 24.6 - Prob. 19PCh. 24.7 - How do the structure of tetrahydrofolate and...Ch. 24.7 - What is the source of the methyl group in...Ch. 24.8 - Thiols such as ethanethiol and propanethiol can be...Ch. 24 - How does the metal ion in carboxypeptidase A...Ch. 24 - Prob. 23PCh. 24 - Prob. 24PCh. 24 - Prob. 25PCh. 24 - S-Adenosylmethionine (SAM) is formed from the...Ch. 24 - Prob. 27PCh. 24 - What acyl groups have we seen transferred by...Ch. 24 - Propose a mechanism for the following reaction:Ch. 24 - When transaminated, the three branched-chain amino...Ch. 24 - Draw the products of the following reaction, where...Ch. 24 - When UMP is dissolved in T2O, exchange of T for H...Ch. 24 - Dehydratase is a PLP-requiring enzyme that...Ch. 24 - In addition to the reaction mentioned in Section...Ch. 24 - PLP can catalyze both ,-elimination reactions...Ch. 24 - The glycine cleavage system is a group of four...Ch. 24 - Prob. 37PCh. 24 - FADH2 reduces , -unsaturated thioesters to...
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