A Study On Cushing 's Syndrome

According to http://www.webmd.com/, “the adrenal glands don't make enough of a hormone called cortisol, or less often, a related hormone called aldosterone.” That's why doctors sometimes call the illness ''chronic adrenal insufficiency,'' or hypocortisolism. “most important function is to help the body respond to stress. It also helps regulate your body's use of protein, carbohydrates, and fat; helps maintain blood pressure and cardiovascular function; and controls inflammation.” Aldosterone helps your kidneys regulate the amount of salt and water in your body -- the main way you regulate blood volume and keep your blood pressure under control. When aldosterone levels drop too low, your kidneys cannot keep your salt and water levels in balance. This makes your blood pressure drop. “There are two forms of Addison's disease. If the problem is with the adrenal glands themselves, it's called primary adrenal insufficiency. If the adrenal glands are affected by a problem starting somewhere else -- such as the pituitary gland -- it's called secondary adrenal

     Cortisol is in the class of hormones called glucocorticoids and affects almost every organ in the body. One of the most important functions of cortisol is to help regulate the body’s response to stress. Cortisol is also responsible for other necessary functions including: helping to maintain blood pressure and

Cushing 's syndrome (CS) is characterized by pathologically elevated free glucocorticoid levels. Endogenous hypercortisolism is usually due to ACTH-secreting pituitary corticotropic adenomas and less often due to ectopic ACTH-secreting neuroendocrine neoplasms or ACTH-independent adrenal cortisol hypersecretion (Yaneva, 2010). Cushing 's disease occurs infrequently in an inherited setting in both of these conditions (Yaneva, 2010).

1. Cushing's disease is a hormonal disorder which is caused by prolonged exposure of the body's tissues to high levels of the hormone cortisol. It is sometimes referred to as hypercortisolism, it is fairly rare and it most commonly affects adults between the ages of 20 to 50. There is an estimated 10 to 15 of every million people who are affected every year.

Failure to produce sufficient levels of cortisol can happen for a couple of reasons. One reason might be due to a disorder of the adrenal glands. When the adrenal glands

Although I’ve never been to Cushing’s in Leavenworth it was great to learn more about the facility from your discussion post. Even though Cushing Hospital is a small facility it seems as though they do a great job taking care of patients. I thought the suggestions you gave were excellent and really could improve staff and patient outcomes. Providing more patient education about medications is a subject matter that I believe all health care facilities need to work on. Valentine et al (2013) states that achieving quality outcomes is a team sport and everyone has to be involved and willing to collaborate. This statement rings true because patient education is an issue that all staff members should be working on. When physicians prescribe a new

A disorder that takes place when your body produces an insufficient amount of certain hormones that are produced by the adrenal glands is called Addison’s disease. With Addison’s disease, the adrenal glands do not produce enough cortisol and often times an insufficient amount of aldosterone as well. Doctors sometimes refer to Addison’s disease as the illness of chronic adrenal insufficiency, or also called hypocortisolism.

This may have been useful when you were out hunting and about to encounter danger because cortisol can give you a quick burst of energy for survival, increased immunity, and enhanced memory function. However, in our environment now, having high chronic levels of cortisol in your body can lead to many negative side effects. Since glucocorticoids stimulate the liver to convert amino acids to glucose, this leads to a rise in blood glucose concentration and can reduce the sensitivity of target tissues to insulin (p. 341).

Obesity is known to contribute to metabolic abnormalities. Findings of this study suggest that obesity also reflects Cushing's through hormonal interaction.

Cushing’s is a disease in which you have an abnormally elevated level of cortisol. There are two major types of Cushing’s. The first type of Cushing’s is rare and is called “Cushing’s Disease”, it’s cause by an endogenous factor, which means that something goes wrong inside your body. This type is usually characterized by the body’s own overproduction of ACTH, Which controls Cortisol. Other internal factors that may cause Cushing’s Disease is a pituitary gland tumor (can be benign or cancerous and is the most common), an ectopic tumor that secretes ACTH, an adrenal adenoma (benign) and adrenal carcinomas (cancerous). In very few rare cases people can inherit a predisposition to developing endocrine tumors (Toft 2016). The second type of Cushing’s

Over ninety percent of cortisol in the blood is bound to corticosteroid binding globulin, and about ten percent is in the free, biologically active form, however these levels may vary during times of

70% of the patients that are diagnosed with Addison’s suffer from an autoimmune disease like HIV (Renz, 2012). Very rarely will it be a genetic mutation they are born with but it does happen. Another cause is malignancy. Tumors metastasize from another organ and start disrupting the hormone flow of the adrenal glands, like lymphoma (Renz, 2012). Another cause is long lasting infections like tuberculosis (Lovas & Husebye, 2005). This is how Addison’s disease was originally diagnosed. Over time, tuberculosis evolves and starts causing a hormone mix-up. On occasion, Addison’s may be caused by trauma. This is the case when it comes to the author’s father. The pituitary gland can be damaged based on the high mechanism of injury to the brain. The pituitary controls all the glands in the human body including the adrenal glands. To put it all in perspective, Addison’s disease basically creates an all-out warfare between your anti-bodies and your adrenal

The basic cause for Equine Cushing's Disease is the lack of dopaminergic control within the intermediate lobe. As a result peptide hormones are overly secreted into the body. Melanotrophs of the intermediate lobe release pro-opiomelanocortin (POMC) into the body. This is then split to form three hormones: α-melanocyte–stimulating hormone (α-MSH), β-endorphin (β-END)–related peptides and corticotropin-like intermediate peptide (CLIP). Normally, dopamine binds to 2 inhibitory receptors on the melanotrophs, stoping the production of hormones. This function is lacking in individuals with Equine Cushing's Disease. Consequentially hypertrophy, hyperplasia, and over production of POMC peptides occur in the intermediate lobe of the pituitary gland.

When a dog has too much Cortisol in their body (usually in their adrenal glands), it can result in them getting Cushing's disease. It is the most common hormone related disease in dogs.There are other causes of this disease in dogs like taking medicine with Cortisol in it for a long period of time or having a tumor in the adrenal gland. However, the main cause of this disease in dogs is their bodies producing too much Cortisol.

5.Cushing's syndrome: a constellation of symptoms caused by steroid excess in the blood. The symptoms include humped back, muscle thinning and weakness, and lowered immunity.