Abstract On Alzheimer's Disease

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Alzheimer’s disease is a neurodegenerative disorder that represents the most common type of dementia in the elderly. The disease is characterised by progressive dementia that inevitably leads to incapacitation and death. The most common and distinctive hallmark lesions present within the disease brain are the senile plaques and neurofibrillary tangles. The amyloid plaques is a major component of the disease, and is constituted mainly by the neurotoxic amyloid-β42, which is a product of the amyloid precursor protein. Mutations on the amyloid precursor protein alters the proteolytic processing, leading to overproduction and accumulation of the neurotoxic amyloid-β42, generating a progressive deposition of protein fragments in amyloid
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