Advantages And Disadvantages Of Cellulose

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as a white, odorless, tasteless, crystalline powder composed of porous particles. It is commercially available in different particle sizes and moisture grades that have different

Use Concentration (%)
Adsorbent 20–90
Antiadherent 5–20
Capsule binder/diluent 20–90
Tablet disintegrant 5–15
Tablet binder/diluent 20–90

Typical Properties Angle of repose
498 for Ceolus KG;

34.48 for Emcocel 90M.(9) Density (bulk) 0.337 g/cm3;

Melting point:-260–2708C.

Moisture content:-Typically less than 5% w/w.
Particle size distribution:-mean particle size is 20–200 mm.

Solubility:- Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents.

Specific surface area 1.06–1.12m2/g
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Following hydrolysis, the hydrocellulose is purified by filtration


and the aqueous slurry is spraydried to form dry, porous particles of a broad size distribution.

3.Magnesium Stearate

Nonproprietary Names
BP: Magnesium Stearate

JP: Magnesium Stearate PhEur: Magnesium Stearate USP-NF: Magnesium Stearate

Synonyms:-Dibasic magnesium stearate; magnesium distearate; magnesii stearas; magnesium octadecanoate; octadecanoic acid, magnesium salt; stearic acid, magnesium salt; Synpro 90.

Chemical Name and CAS Registry Number:-Octadecanoic acid magnesium salt [557-04-0]

4 Empirical Formula:- C36H70MgO4
Molecular Weight:-591.24

The USP32–NF27 describes magnesium stearate as a compound of magnesium with a mixture of solid organic acids that consists chiefly of variable proportions of magnesium stearate and magnesium palmitate (C32H62MgO4). The PhEur 6.5 describes

magnesium stearate as a mixture of solid organic acids consisting mainly of variable proportions of magnesium stearate and magnesium palmitate obtained from sources of vegetable or animal origin.

Structural Formula:-[CH3(CH2)16COO]2Mg

Functional Category:-Tablet and capsule
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Hardness:- (Mohs) 1.0–1.5

Moisture content :-Talc absorbs insignificant amounts of water at 258C and relative humidities up to about 90%.

Particle size distribution:- Varies with the source and grade of material. Two typical grades are 599% through a 74 mm (#200 mesh) or 599% through a 44 mm (#325 mesh).

Stability and Storage Conditions:-Talc is a stable material and may be sterilized by heating at 1608C for not less than 1 hour. It may also be sterilized by exposure to ethylene oxide or gamma irradiation.(10)

Talc should be stored in a well-closed container in a cool, dry place.

Method of Manufacture

Talc is a naturally occurring hydropolysilicate mineral found in many parts of the world including Australia, China, Italy, India, France, and the USA.

Purity:-The purity of talc varies depending on the country of origin. For example, Italian types are reported to contain calcium silicate as the contaminant; Indian types contain aluminum and iron oxides; French types contain aluminum oxide; and American types contain calcium carbonate (California), iron oxide (Montana), aluminum and iron oxides (North Carolina), or aluminum oxide
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