as a white, odorless, tasteless, crystalline powder composed of porous particles. It is commercially available in different particle sizes and moisture grades that have different
Applications
Use Concentration (%)
Adsorbent 20–90
Antiadherent 5–20
Capsule binder/diluent 20–90
Tablet disintegrant 5–15
Tablet binder/diluent 20–90
Typical Properties Angle of repose
498 for Ceolus KG;
34.48 for Emcocel 90M.(9) Density (bulk) 0.337 g/cm3;
Melting point:-260–2708C.
Moisture content:-Typically less than 5% w/w.
Particle size distribution:-mean particle size is 20–200 mm.
Solubility:- Slightly soluble in 5% w/v sodium hydroxide solution; practically insoluble in water, dilute acids, and most organic solvents.
Specific surface area 1.06–1.12m2/g
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Following hydrolysis, the hydrocellulose is purified by filtration
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and the aqueous slurry is spraydried to form dry, porous particles of a broad size distribution.
3.Magnesium Stearate
Nonproprietary Names
BP: Magnesium Stearate
JP: Magnesium Stearate PhEur: Magnesium Stearate USP-NF: Magnesium Stearate
Synonyms:-Dibasic magnesium stearate; magnesium distearate; magnesii stearas; magnesium octadecanoate; octadecanoic acid, magnesium salt; stearic acid, magnesium salt; Synpro 90.
Chemical Name and CAS Registry Number:-Octadecanoic acid magnesium salt [557-04-0]
4 Empirical Formula:- C36H70MgO4
Molecular Weight:-591.24
The USP32–NF27 describes magnesium stearate as a compound of magnesium with a mixture of solid organic acids that consists chiefly of variable proportions of magnesium stearate and magnesium palmitate (C32H62MgO4). The PhEur 6.5 describes
magnesium stearate as a mixture of solid organic acids consisting mainly of variable proportions of magnesium stearate and magnesium palmitate obtained from sources of vegetable or animal origin.
Structural Formula:-[CH3(CH2)16COO]2Mg
Functional Category:-Tablet and capsule
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Hardness:- (Mohs) 1.0–1.5
Moisture content :-Talc absorbs insignificant amounts of water at 258C and relative humidities up to about 90%.
Particle size distribution:- Varies with the source and grade of material. Two typical grades are 599% through a 74 mm (#200 mesh) or 599% through a 44 mm (#325 mesh).
Stability and Storage Conditions:-Talc is a stable material and may be sterilized by heating at 1608C for not less than 1 hour. It may also be sterilized by exposure to ethylene oxide or gamma irradiation.(10)
Talc should be stored in a well-closed container in a cool, dry place.
Method of Manufacture
Talc is a naturally occurring hydropolysilicate mineral found in many parts of the world including Australia, China, Italy, India, France, and the USA.
Purity:-The purity of talc varies depending on the country of origin. For example, Italian types are reported to contain calcium silicate as the contaminant; Indian types contain aluminum and iron oxides; French types contain aluminum oxide; and American types contain calcium carbonate (California), iron oxide (Montana), aluminum and iron oxides (North Carolina), or aluminum oxide
C.quartz chert. Correct D.shale. Answer Key: D Feedback: The correct answer is D. shale. Question 18 of 33 3.03/ 3.0303 Points Specimen #16 is composed of Correct A.silica. B.calcium carbonate.
Prior to the 1970s, some talcum products used in the home contained asbestos. Asbestos is a substance that can cause lung cancer when inhaled; however, since that time this natural-occurring asbestos has been removed from modern consumer products that contain talc. Unfortunately,
When the organometallic carbon is used to attack an electrophilic carbon, a new C-C bond forms and the C =O double bond breaks. By adding an alkyl or aryl halide, bromide, to magnesium metal in an aprotic solvent
Amethyst is purple quartz; the color is caused by iron (Fe4+) impurities. Azurite is a copper mineral. Calcite is a very common and widespread mineral and has highly variable forms and colors. Lodestone is a natural magnet. Mica is a sheet silicate. Rose quartz is translucent and a variety of the silica mineral quartz, found in pegmatite. Talc almost always found in foliated masses in metamorphic rocks with many carbonate minerals. Pyrite is a very common mineral. The brassy-yellow metallic color of pyrite has lead people to mistaking it for Gold, so its common nickname is
Solids are composed of atoms, ions or molecules arranged in a pattern that is represented in three dimensions, they all have a definite shape and volume, they are virtually incompressible and they do not flow readily.
has to use a mix of chemicals along with water to actually get the job done, all of the chemicals
Magnesium of which can be found in bone and teeth, plays a key role in the contraction of muscles as well as an activator for various enzymes.
| A milky white aqueous suspension of magnesium hydroxide use as antacid and a laxative.
At the end of 2006, Luzenac, who was another talc distributing company, stopped defending the safety of talc because there were too many studies proving them wrong. After coming to this decision, they placed a warning on the safety data sheet included with the 2,000 pound bags of talc they deliver to Johnson & Johnson. The warning says: Perineal use of the powder is a possible risk factor for ovarian
Purpose: Applying mass relationships, demonstrate that magnesium and oxygen conjoin in a definite whole-number ratio by mass.
Expectedly, the soil and a variety of dense particles settled to the bottom of the test tube. Using a pipette we drew water from the center of the sample, but making sure not to draw up any soil. Three separate slides were prepared, each
Howard A. Zimmerman, although a little strange, was a normal everyday guy. However, he did not have many friends because he lived much of his life in the laboratory. His fascination with mixing and testing the various elements on the periodic table went far beyond a job, it was an obsession. A little over a year ago, Howard accepted a job at Rex Industries in Toronto, Canada. It was an exciting opportunity for Howard because he had never traveled outside the United States. He could not pass up the opportunity to test magnesium, which happened to be his favorite element. Magnesium is found in the earth's crust and is the eighth most abundant element but does not occur uncombined in nature. At room temperature magnesium will become a solid. He
The week after, a recrystallization was performed on the previous week’s crude product. The product ethereal solution was first heated on a steam bath until dry. During the heating, a beaker of methanol was collected and also placed on the steam bath. Once the product was dry, it was cooled to room temperature and then placed in an ice-water bath. The now boiling methanol was added to the crude crystals and a recrystallization was performed. Once completed, the now purified product was collected via Buchner vacuum filtration and stored in drawer to dry for a week. Afterwards, a melting point range of the purified product was obtained by using a Mel-temp apparatus. Lastly, an
moisture and made solid, and can be dissolved neither by the waves nor the power of