Alzheimer's Disease

Throughout this line of study, Alzheimer’s disease is a specific form of dementia. According to Alzheimer’s Association, dementia is a general term for a decline in mental ability that is severe enough to hinder daily life. Memory loss is a symptom of dementia and the most common type of dementia is Alzheimer’s. One of the most common and severe symptom of Alzheimer’s is difficulty remembering newly learned information. The changes of Alzheimer’s normally begin in the part of the brain that affects learning (Overview Alzheimer's Association). Some other symptoms of Alzheimer’s include gradual memory loss, the decline in capability to carry out everyday tasks and the loss of their language skills. According to Bialystok the rate of

In times past many people thought that memory loss was a normal occurrence for elderly people. This thinking was major reason for why Alzheimer’s disease was not caught until very later in the stages. Alzheimer’s disease is not a normal part of aging. After heart disease, cancer, and strokes, Alzheimer’s is the most common cause of death in adults in the Western world. “It is estimated that 4.5 million Americans over the age of 65 are affected with this condition. After the age of 65, the incidence of the disease doubles every five years and, by age 85, it will affect nearly half of the population” (Robinson).

c) Age-related cognitive impairment (or mild cognitive impairment MCI) – is when an elderly person’s memory starts to wane and they have problems recalling their short term memories, they have difficulty learning new things, their thinking process starts to become reduced and have difficulty concentrating. It is thought that MCI can develop due to alcohol abuse and cognitive decline (poor diet, chronic inflammation, vascular disease and

The disease called Alzheimer’s is the fourth leading cause of death in the United States (Weiner, 1987). It is estimated that the elderly population will double between now and 2030. During this period, the number of elderly will grow by an average of 2.8% annually (U.S. Census Bureau, 2001). By 2050, the number of people with Alzheimer’s is estimated to range from 11.3 million to 16 million (Alzheimer’s Association, 2005). These startling numbers should prompt an examination into one of the leading causes of death among this group of people. Understanding what Alzheimer’s is and the known causes of the disease are a good starting point. For those who have aging family members, knowing the risk factors and warning

The disease stem cells could fix is called Alzheimer’s Disease (AD). The reason I chose this topic is because I have seen first hand how badly someone who suffers from Alzheimer’s Disease is affected in their daily lives. This disease completely takes over their lives and they turn into a completely different person who can hardly function. AD is very tough on the loved ones of the person suffering from it because that person, most of the time has no idea what is going on or who their loved ones are. The memories for people with AD is completely gone and even the simplest tasks such as remembering to use the bathroom becomes difficult. The way stem cells could be feasible is because stem cell-based therapies could potentially treat

Alzheimer 's disease (AD) is a progressive degenerative disease of the brain from which there is no recovery. There are three brain abnormalities that are the hallmarks of the Alzheimer’s disease is initially caused by plaques buildup in the brain’s neurons as illustrated in figure 1. The support structure that allows the flow of the nutrients through the neurons gets damaged and ultimately there is loss of connection among the neurons and they die off (National Institute of Health, 2015). This causes the brain tissue to shrinks, which is called atrophies. All this ultimately lead the victim of this disease to face difficulties in governing emotions, recognize errors and patterns, coordinate movement, and remember. Ultimately, a person with AD loses all memory and mental functioning.

Alzheimer’s Disease has been one of the top leading causes of death in our country. It is understood that this disease is identified as an excess of the protein amyloid-ß within an increase of plaque (Seneff, Wainwright, and Mascitelli, 2010). Additionally, as the brain ages, it gets used to the inflammation and oxidative stress, so it is important to take the right amount of antioxidant micronutrients like vitamin C and vitamin E as well as anti-inflammatory macronutrients such as omega-3 polyunsaturated fatty acids to protect the brain from ageing (Whalley et. al, 2004). This is a devastating disease that affects most people over the age of fifty. Recently, there have been many studies done to figure out what causes this disease, if there is anything that can cure it, and how to prevent the disease. Seneff, Wainwright, and Mascitelli, believe Alzheimer’s develops with consuming too many carbohydrates, especially fructose and having a deficiency in cholesterol and dietary fats as well (2010). Whalley, Starr, and Deary have seen that poor diet, poverty, and failing health are links to developing Alzheimer’s Disease (2004). Furthermore, seeing increase in plasma homocysteine concentration increases risk of Dementia, which can result from an inadequate intake of vitamin B12/folate (Walley et. al, 2004). Additionally, Gray supports Walley’s findings and even believes having an adequate intake of vitamin B12/folate will have a positive effect on the overall health

In a study that was done called aging, demographics and memory study (ADAMS) it was found that older African Americans are two times more likely than older whites to develop Alzheimer or any other dementia. Some of the reasons that have been discovered as to why older African Americans are more common to have Alzheimer’s is because they are found to have higher rates of high blood pressure, diabetes, along with other vascular diseases. Some other factors that can affect who may end up with Alzheimer’s are lower level of education, and socioeconomic characteristics which are found to be more common in African Americans. In the health and retirement study (HRS) 80% of African Americans were found to have high blood pressure. Other risks that have been found to have increased risk of Alzheimer’s are those with lower educations, low income being below $18,000 a year, and

Alzheimer’s disease is a prominent brain disease that effects a massive amount of individuals in the United States. Alzheimer’s disease (AD) is the sixth leading cause of death in the United States, accounting for 60-80% of dementia cases, with no chance of being cured, prevented or decelerating over time (Alzheimer’s Association, 2014). AD is the most well-known form of dementia, causing complications in brain function in the areas of memory, thinking, and behavior (Alzheimer’s Association, 2014). In an effort to gain a deeper understanding of Alzheimer’s disease, researchers create new knowledge about the disease, which is then distributed to the public. The goal in this information disbursement is to find new and inventive ways to treat AD, prevent AD from progressing at such a rapid pace, and aid in the quality of life in those diagnosed with AD as well as caregivers and medical professionals providing treatment to individuals’ with AD.

Intelligence refers to the ability to obtain information and apply skills and consists of different functions, memory, reasoning, logic; these are all controlled by different areas of the brain. Alzheimer’s Disease inhibits short term memory first, before it continually moves throughout the brain, eventually affecting part of the brain that controls involuntary functions. With this in mind someone with MCI would not be able to make clear judgments and recall memory stored in long term memory. The deterioration of short term and working memory will inhibit a person’s ability to

Alzheimer’s disease is a complex illness that affects the brain tissue directly and undergoes gradual memory and behavioral changes which makes it difficult to diagnose. It is known to be the most common form of dementia and is irreversible. Over four million older Americans have Alzheimer’s, and that number is expected to triple in the next twenty years as more people live into their eighties and nineties. (Johnson, 1989). There is still no cure for Alzheimer’s but throughout the past few years a lot of progress has been made.

Alzheimer’s disease (AD) is a progressive and fatal form of dementia, frequently seen in the elderly altering their cognition, thought process and behavior. AD is reported in about half of patients that have a dementia diagnosis; one study states that about 10.3% of the population over 65 years is affected by dementia with an increase to almost 50% over the age of 8 (Beattie, 2002). Alzheimer’s disease is not a normal part of the aging process in humans, but rather found in a group of diseases that affect the brain leading to a decline in mental and physical control. AD when diagnosed has a very slow and gradual course, initially affecting the individual’s short term memory (Beattie, 2002). Alzheimer’s disease is the 6th leading cause of death, affecting more than five million people in the United States and is also one of the most common forms of dementia. Dementia can be defined as a disorder of progressive cognitive impairment severe enough to affect daily functions of an individual’s life (Fillit, et al., 2002).

Alzheimer’s disease progresses through many stages, ranging from early to severe. Memory problems are normally one of the first warning signs of cognitive loss, possibly due to the development of Alzheimer’s disease. However, some people with memory problems present with a condition called amnestic mild cognitive impairment (MCI). People with this condition have more memory problems than normal for people their age, but symptoms are not quite as severe as those seen in people with Alzheimer’s disease. Some researchers have found those people with MCI also present with movement difficulties and problems with sense of smell. The ability of people with MCI to perform daily activities is not significantly impaired. Although, older people with MCI when compared to those without MCI, do go on to develop Alzheimer’s disease.

Throughout history there have been reports of decreased memory and mental deterioration that accompanied old age. Alzheimer’s disease (AD) was named after Dr. Alois Alzheimer who described the symptoms in a woman in Germany in the 1907 but it was not until the 1970’s that AD was considered to be a major disorder and AD continues to be a major health concern worldwide (Reger, 2002).

The idea of functional Magnetic Resonance Imaging (fMRI) is blood oxygen level dependent (BOLD). Functional Magnetic Resonance Imaging (fMRI) is a technique used to visualize brain activity by detecting changes in blood flow. fMRI creates images of physiological activity correlated with neuronal activity. The idea of BOLD relies on the fact that, a certain activated area in the brain requires increased blood flow. The blood entering the area is oxygen enriched (oxygenated hemoglobin) and results in a decrease of deoxy-hemoglobin. Now, a BOLD contrast can be defined as the signal generated by suppression of de-oxy blood over oxy-blood. The review manifests that older adults indicate high activation of the BOLD signal in contrast to younger adults. However, a rise in activation is related to risk factors in Alzheimer 's Disease (AD), including the apolipoprotien ε4 allele. fMRI is used to envision the effect of neurodegenerative diseases such as Mild Cognition Impairment (MCI) and AD, on brain function and its association with cognitive deficit. Cabeza 's research exhibited that younger adults show greater hemispheric lateralization in prefrontal activity than older adults, when compared on the basis of memory, perception and inhibitory control. Further, this age-related change in hemispheric lateralization during cognitive tasks was termed ‘‘hemispheric asymmetry reduction in older adults,’’ or the HAROLD model (Cabeza 2002). HAROLD model suggests that one of the reasons