In the world of pharmaceuticals, “there is a continuing interest in developing once-daily medications to further simplify treatment regimens and improve patient compliance”, especially when treating COPD and Asthma 1. “Suitable therapies for asthma and COPD need to provide targeted, long lasting and consistent efficacy” 2. This research paper summarizes the current clinical findings of a new drug called Abediterol a LABA. In addition to this, we will also summarize the most current research on abediterol versus the current SABA’s albuterol, and LABA’s salmeterol, indacaterol, olodaterol, and vilanterol in its treatment of asthma. Abediterol is a promising new potent LABA, currently in Phase II development. This is a drug that is used as a once daily treatment for chronic obstructive pulmonary disease COPD and asthma in combination with an Inhaled Corticosteroids ICS 3.
Asthma is one of the most common diseases, it affects nearly 300 million people worldwide, and 25 million here in the US 4. “Worldwide, the number is expected to increase to 400 million by 2025” 4. Asthmas primary symptom is airflow obstruction, which results from narrowing of the airways in the lungs. Some common causes of asthma include smooth muscle contraction, inflammation, excessive mucus production, and foreign body or allergens.
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This local and systemic inflammation can affect daily functioning and quality of life 5. COPD patients usually have symptoms of chronic bronchitis and emphysema. The inflammation of the lungs causes the development of thickened walls, which causes mucus to build up blocking the airways leading to symptoms of bronchitis 5. In emphysema alveoli in the lungs are gradually destroyed, leading to decreased surface area needed for gas
A quite common, yet still horrible disease that people suffer from is asthma, which my uncle suffers from. It’s a terrible thing when you see them pull out that inhaler. You see the pain in their eyes. Also, how they have suffered with this horrendous condition of simply not being able to breath. Asthma is a non-communicable disease that plagues many people around the globe.
– Chronic steroid therapy for COPD must be evaluated during treatment of the acute respiratory failure
Chronic Obstructive Pulmonary disease (COPD) is the third leading cause of death in the United States. “COPD affects over 24 million Americans and our community stretches across all 50 states.” (COPD Foundation, 2016, p. 1). In this paper we will go over the main causes of COPD, what is emphysema and chronic bronchitis, the symptoms, also we will cover the different stages COPD and some of the common treatments. Although COPD does not discriminate by age it is primarily found to affect the middle age and older group. As we go further
Asthma is a chronic breathing condition that has no cure. However, the good news is that patients can live a normal life with the right treatment. Below is a list of treatments that are available for asthma:
I have chosen asthma for my noncommunicable disease because my mom, and brothers and I have it. My little brothers and my mom had it when they were born but I got it when I turned 12 years old. Asthma is a disease someone gets in their lungs that inflames and narrows the airways.
Hello, I'm Violet Martinez. I am a twenty year old female, suffering from a non-infectious disease called asthma. When I was one and a half years old I was diagnosed with asthma.
It has been well established that inflammation within the airways is a feature in all forms of asthma. There are varying degrees of inflammation, ranging mild asthma to severe asthma. However, characteristics of the cellular infiltrate may also vary between mild and more severe forms, resulting is an increased need to improve the understanding of moderate to severe asthma (Yeadon & Diamant,
An estimated 300 million people worldwide suffer from asthma, with 250,000 annual deaths attributed to the disease. This respiratory condition marked by spasms in the bronchi of the lungs, causing difficulty in breathing. Galen (130-201 AD), a Greco-Roman doctor, discovered that asthma was due to bronchial obstruction. He treated it with owl's blood in wine. Patients with severe persistent asthma are at greatest risk for life-threatening attacks, but all patients are at some risk. Fatal attacks can range from minutes to hours. Severe asthma can make daily life hard, and hard to do things without being short of breath.
Asthma is a common disease in America. About 24 million people have asthma. So, what exactly is this disease? Asthma is a long term disease in the lungs that affects a person’s breathing and compresses the airways. There are many factors that contribute to the cause of asthma and treatments that go along to help prevent it. Although scientists still don’t have an exact understanding as to why some factors might cause asthma, there are still many theories.
Asthma is a common respiratory disorder that is mediated by T helper type 2 (TH2) cytokine production, leading to airflow obstruction and airway hyper-responsiveness. Infant infection of human respiratory syncytial virus (RSV) has been shown to be the greatest risk factor for developing asthma. Interferon regulatory factor 7 (IRF7), activated by TLR7 in pDCs, is a crucial regulator of type I interferon (IFN) in the antiviral response. This paper provides preliminary data to show that IL-13 levels are significantly increased in IRF7
Asthma is among the diseases that have shown a significant increase in prevalence in recent attacks of wheezing. Asthma is a chronic condition characterized by periodic attacks of wheezing, coughing and shortness of breath. More than 7 million US children suffer from it and worldwide it’s nearly 150 million. Asthma constrict the airways that lead to the lungs and partially block the passage for air to pass through.
Asthma treatment is an area of ongoing research that has provided both pharmaceutical and herbal remedies as potential treatments for the elimination of symptoms, and preferable the condition altogether. An increasing number of patients are seeking natural alternatives for primary treatment. Numerous studies have been conducted by herbalists correlating the use of particular herbs and the reduction of asthma symptoms in patients.
Asthma is a chronic disorder of the respiratory system that involves airway obstruction, bronchial hyper responsiveness and inflammation of airways that is commonly caused by allergens or other forms of sensitivity. The causes of asthma are not fully understood but the underlying factors that contribute to the onset of it have been confirmed. Genetic factors along with exposure to environmental factors such as inhalable substances or particles may inhibit the onset of an allergic reaction or irritate the airways causing an episode of asthma. Common irritants that contribute to an asthma attack include;
Currently the 4th leading cause of mortality worldwide, COPD or Chronic Obstructive Pulmonary Disease is reported to account for more than three million deaths per year 1 and is estimated to rank fifth in disease burden in 20202. The Global Initiative for Obstructive Lung Disease (GOLD) guidelines updated their definition of COPD in 2006 as “a preventable and treatable disease with some significant extra-pulmonary effects that may contribute to the severity in individual patients. Its pulmonary component is characterised by airflow limitation that is not fully reversible. The airflow limitation is usually progressive and associated with an abnormal inflammatory response of the lungs to noxious particles or gases”3.
During one of my clinical rotations, I had a patient under my care that had a case of asthma attack. Asthma is an inflammatory condition that is chronic. It affects the bronchial mucosa resulting in an excessive responsiveness and airway constriction. According to Huether & McCance (2012), more than 100 genes are recognized for the pathogens and vulnerability of asthma. This journal will elucidate potential predisposing genetic and environmental factors associated with asthma.