Information Flowing Through The Bla-To-Pl Projection May

817 WordsFeb 21, 20174 Pages
Information flowing through the BLA-to-PL projection may be the dominant route for reward behavior. PL is important for the enhancement in reward-seeking behavior when the deprived animal is re-exposed to the previously rewarding context (reinstatement)(Gourley & Taylor, 2016). PL is also important for discriminative reward seeking(Sangha et al., 2014). The BLA-PL projection is important for reinstatement. BLA modulates the activity of PL responding to the CS (Gourley & Taylor, 2016). Both IL and PL of the mPFC has reciprocal projections with the BLA. It is unclear the functional contribution of projections in the reciprocal direction such as PL-to-BLA projection in fear learning, BLA-to-IL projection in safety learning, and PL-to-BLA…show more content…
During learning, many physiological changes can be found to correlate with behaviors. However neural correlates that are not part of the dominant circuit may play a modulatory role in affecting learning rate, or it can have no effect on behavior as they may simply be passive relays from other structures. Critical structures and their projections are major contributors as the absence of any one of them will abolish behavior. Dysregulations that abolish behavioral performance must be either part of or at least influencing critical structures on the circuit. Focusing on circuits that contain only the necessary components is critical to narrow the search for malfunctioning elements that lead to downstream changes and cause behavioral impairment. Results from these aims would refine the current circuit underlying SFRLD. In turn, this information would be vital for electrophysiologically monitor information flow from major contributors throughout the pathway and set the stage for identifying cellular level abnormalities from critical structures. In order to restore the behavioral impairment in safety acquisition and reward regulation, treatment for PTSD-AD will need to rescue dysregulations in the critical structures or pathways. Innovation Most studies look at fear and reward learning separately (Janak & Tye, 2015). The research proposed here is conceptually

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