MITOCHONDRIAL GENOME ABSTRACT Mitochondria are double membraned cell organelle that plays central role in cellular energy provision . These organelles have their own genome which is small in size and are transmitted exclusively through female germ line. The human mitochondrial DNA (mtDNA) is a double-stranded, circular and has 16 569 bp which contains 37 genes coding for two rRNAs, 22 tRNAs and 13 polypeptides which are required in oxidative phosphorylation. INTRODUCTION Mitochondria in eukaryotes generates ATP through the process of oxidative phosphorylation. Mitochondrial outer membrane seperates it from cytosol and its inner membrane have enzyme complexes required for oxidative phosphorylation. Mitochondria have their own genome
Mitochondria are small organelles found in eukaryotic cells which respire aerobically. They are responsible for generating energy from food to ‘power the cell’. They contain their own DNA, reproducing by dividing in 2. As they closely resemble bacteria, it gave the idea that they were derived from bacteria (which were engulfed by ancestors of the eukaryotes we know today). This idea has since been confirmed from further investigations, and it is now widely accepted. (Alberts et al., 2010a)
The mitochondria is an organelle of a cell. It works as it was the digestive system, it’s in charge of obtaining the nutrients, then break them down, and finally, all that work is for maintaining the cell full of energy, so they would be as the power plants of the cell. The mitochondria are in charge of creating 90% of the energy that our bodies need so it can sustain life and support our growth. The mitochondria are small organelles that floats all through the cell. Some cells have many, lots of mitochondria, but others just have none; for example, the muscle cells need a lot of energy, so they contain lots of mitochondria, otherwise, neurons don’t need as much. Depending of the quantity of energy that the cell needs, mitochondria could be created.
Mitochondrion’s most important job is to produce energy through cellular respiration. Mitochondria does this by taking in nutrients from the cell itself, breaking it down and then turning it into energy. Then, the energy gathered is utilised by the cell to carry out various functions, hence this organelle is also known as the ‘powerhouse’ of the cell. Its purpose is to keep the cell full of energy.
Until recent years, the mitochondrial genome, located in the mitochondrion, and the genetic information encoded by it have been given little attention. However, recently it became apparent that the mitochondrial genome, despite its small size, is crucial for the study of human evolution and disease, as mtDNA mutations lead to some serious diseases.
The hub of energy metabolism, the mitochondrion, is found in virtually all eukaryotic cells, with the exception being erythrocytes. The mitochondrion generates cellular energy in the form of adenosine triphosphate (ATP), mostly by means of the oxidative phosphorylation (OXPHOS) system that is located in the inner mitochondrial membrane. The respiratory chain (CI-CIV) and ATP synthase (CV) is collectively known as the OXPHOS system, encoded by both nuclear DNA (nDNA) and mitochondrial DNA (mtDNA). The number of mitochondria per cell, ranging from hundreds to thousands, is controlled by the energy requirements of specific tissues with the greatest abundance of mitochondria found in metabolic active tissue (Pieczenik and Neustadt, 2007). Mitochondrial disease is caused when there is a defect in any of the numerous mitochondrial pathways, due to spontaneous or inherited mutations. Respiratory chain deficiencies (RCDs) are the largest subgroup of mitochondrial disease and occur when one of the four respiratory chain complexes become impaired. RCDs are considered to be one of the most common
The Mitochondria is one of the organelles. This is the cells source of energy, which means the energy from respiration is converted into glucose.
As mitochondria are present in every cell (except RBC), the main function of mitochondria is generating ATP (energy currency) via oxidative metabolism of tricarboxylic acid cycle,
Mitochondrion is an importance structure that lies in the cytoplasm area. Mitochondrion is the plural word for mitochondria, which is the key organelle that converts energy from one form to another. Mitochondria changes the chemical energy stored in food into compounds that are more convenient for the cell to use. The mitochondrion contains two special membranes. The outer membrane surrounds the organelle, and the inner membrane has many folds that increase the surface area of the mitochondrion.
The mitochondria is referred to as a “powerhouse” of a certain cell. This membrane bound organelles main job is to perform cellular respiration, which in simple terms, is when it breaks down diffused nutrients into usable energy for the whole cell. Adding on to that, the mitochondria also contributes to the making of ATP (Adenosine Triphosphate) by providing 3% of its genes for it. ATP is basically a complex nanomachine that provides a “primary energy currency” for a cell.
Find a labeled diagram of the mitochondria, attach it to this page, and place the web address next to the picture.
Mitochondria are rod-shaped organelles that can be considered the powerhouse of the cell. Mitochondria generate chemical energy in the form of adenosine triphosphate by metabolizing sugars, fats, and other chemical fuels with the assistance of molecular oxygen in a process called aerobic respiration and mitochondria enable cells to produce 15 times more ATP than they could otherwise. The number of mitochondria present in a cell depends upon the metabolic requirements of that cell, and may range from a single large mitochondrion to thousands of them. mitochondria are different from most organelles because they have their own DNA and reproduce independently. In most animal species, mitochondria appear to be inherited through the
Mitochondrial are dynamic organelles that are involved in a number of functions essential for the maintenance of cellular homeostasis. To maintain the energetic state of the cell mitochondria maintains a subtle balance between fission and fusion to regulate mitochondrial number, mitochondrial shape, and network as unbalanced fission and fusion can have deleterious impact on cellular metabolism, energy status and redox homeostasis. Further, mitochondrial and neuronal activities are closely integrated to one another as injuries in mitochondria compromises neuronal function and survival. Mitochondrial dynamics impacts mitochondrial genome integrity, bioenergetics and neuronal functions including synaptic maintenance
Mitochondria are organelles found in the cytoplasm of eukaryotic cells and play a crucial role in the respiration of the cell (Bandelt et al, 2006). Mitochondria are thought to have originated as free-living bacteria that parasited proto-eukaryotic cells~1.5 billion years ago and have since remained in an endosymbiotic relationship inside eukaryotic cells (Margulis, 1981). The mitochondria preserve remnants of the original bacterial genome coding for key aspects of the mitochondrial machinery, but over the course of evolution, most mitochondrial genes have been transferred to the nucleus. The extent of these nuclear insertions was estimated to represent at least 400,000 base pairs (bp) in the human genome (Qu, Ma, & Li, 2008). The number of
Mitochondria is a cylindrical organelle surrounded by a double membrane and the outer membrane forms a smooth boundary. The inner membrane is folded to make cristae, inside the inner membrane lies the matrix.
The mitochondria is like the cafeteria. The mitochondria generates cellular energy (ATP). Mitochondria are also involved in other cell processes such as cell division and growth, as well as cell death.Mitochondria are bounded by a double membrane. The cafeteria