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PTSD: A Synthesis Essay

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All the experiments performed by Rau, Decola, & Fanselow support a phenomenon in which prior exposure to several shocks enhances subsequence learning of conditional fear. Based on the data they suggested that this effect occurs because the potent pre-shock experience sensitized the subject’s susceptibility to acquire conditional fear. It also proves that this procedure may serve as a model of specific components of PTSD. This series of experiment provides insight into the possible treatments for PTSD. Neither behavioral nor pharmacological elimination of the fear to the original traumatic context was capable of alleviating the effects of the stressor. It will is important for future studies to determine the mechanisms for this sensitization, which will be able to provide a complete treatment for PTSD.
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This study was the first to propose specific cellular and molecular mechanisms that may be causing stress-enhanced fear learning. It also suggested molecular and cellular targets, including glycine and neuropeptide systems, chromatin remodeling, and gliotransmission, that have the potential to be used for therapeutic intervention in PTSD.
Findings in recent studies that are using stress-enhanced fear learning in rats, developed and tested in Rau et al., as a model for Posttraumatic Stress Disorder has a lot of potential. The model allows for scientist and researchers to learn more about what is happening in the brain as a result of traumatic situations. By pinpointing these molecular and cellular mechanisms in rats, we are able to apply the information to humans who have PTSD. Continuing work on this topic gives the ability to learn more about how to treat PTSD and offers the potential for therapeutic

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