Paper on the Risk Assessment of Dicamba

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Dicamba Risk Assessment Based on Recent Research Advances Abstract Dicamba is an herbicide in widespread use in agriculture. Current dietary safety standards are based on the relative lack of toxicity that this agent has shown in past laboratory tests, but recent research developments may require stricter standards. Exposure of mammalian cells to dicamba in vitro revealed cytotoxic and genotoxic effects at concentrations up to 6-fold lower than the current safety standards are based on. In addition, genetically modified food crops resistant to dicamba have recently been developed, which lead to increases in the concentration being applied to crops and an expansion of use. After accounting for the combined effects of these developments, the dietary margin of safety for the most vulnerable segments of the U.S. population will likely be exceeded. Dicamba Risk Assessment Based on Recent Research Advances In 1967, the United States registered an herbicide called dicamba that was developed by the German chemical company BASF (EPA, 2009, p. 18). Its intended use was to control post-emergent broadleaf weeds and woody plants. Since then, 434 dicamba products have been developed to control weeds in a variety of settings and dicamba is currently the seventh most commonly used herbicide in the U.S. In more recent years, the use of genetically modified (GM) crops to exploit engineered resistance to the herbicide glyphosate (Roundup) has become "… one of the most quickly

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