Endogenous synthesis of vitamin D takes place in two steps. In first step the ultraviolet (UV-B) spectrum (wave length 290-360 nm) impinges on human skin and facilitates the conversion of 7-dehydrocholesterol present in the plasma membrane of the cells in upper skin layers, mainly in the stratum basale and the stratum spinosum to pro vitamin D3. UV light B breaks the B ring of 7-dehydrocholesterol to form a pre D isomer26-27. In second step the Pro vitamin D3 which is inherently unstable rapidly isomerizes to D3 in a thermo sensitive but non catalytic process. With continued exposure of UV-B, Pro- D3 is converted to biologically inactive lumisterol . Tachysterol is also formed but like pro-D3 it does not accumulate with extended UV radiations24,28. The formation of lumisterol and tachysterol is reversible and can be converted back to pre-D3 as pre-D3 levels fall. Thus prolonged …show more content…
The other hand, vitamin D2 and vitamin D3 derived from supplements, fortified foods and fish ingested from the diet are incorporated into chylomicrons and absorbed into the lymphatic system. From here they enter the circulation, where they are bound to the DBP and lipoproteins29-30. Since endogenously synthesized vitamin D3 provide a slower hepatic delivery of the vitamin D and the more sustained increase in plasma 25- hydroxy cholecalciferol in contrast to orally administered vitamin D which associates with chylomicrons and lipoproteins and allow receptor-mediated rapid hepatic delivery of vitamin D but less sustained increase in plasma 25-hydroxycalciferol. Therefore vitamin D3 produced in the skin last 2-3 times longer in the circulation when compared with ingesting it
This lab could have contained errors. The errors could have happened when performing the lab. Some of the possible errors in this lab are:
Abstract: The purpose of this experiment is to use the apparatus shown in figure 7-1 of experiment 6 found in the lab manual, to synthesize [1,3,5-C6H3(CH3)3]Mo(CO)3.(2016 Oleg) With this, characterization of the molecule can be accomplished using the infrared spectrum and NMR spectrum of the synthesized compound. It was found in the IR spectra of the product, that suitable stretches were found associated with the C-O bonds of mestylene and molybdenum. With One strong spectra was found at 1855.3973 cm-1 , one medium strength spectra was found at 1942.6002 cm-1 , and one weak spectra of C-O stretch was found at 1298.8638cm-1 . The 1H NMR spectrum of the product showed peaks at δ 2.28 and 5.25, while the H NMR spectrum of mesitylene gave peaks at δ
Tanning salons also state that some UV radiation is needed for the manufacturing of vitamin D. Vitamin D certifies that a constant level of calcium remains in the blood and controls its absorption. In an advertisement for tanning equipment, one tanning bed company, The Beach House Tanning, claims that the sun is the only source of Vitamin D (http://www.beachouse.com/tanning_benefits.htm). However, vitamin D is also found in foods such as dairy products, cereal, and fish (http://shrike.depaul.edu/~vbard/vitdpg.html), and it takes far less UV radiation to obtain the necessary amount of vitamin D than it does to get a suntan (http://www.fda.gov/cdrh/tanning.html).
Vitamin D plays a critical role in many normal bodily functions as well as fighting against a wide number of health barriers. In an article by Jacqueline Kanopa, studies revealed that exposure to ultraviolet rays play a huge part in Vitamin D production, as well as having preventative effects on a disorder known as rickets; which leads to weakened bones due to lack of Vitamin D. This study supports the belief that exposure to UV rays play a critical role in Vitamin D production, and can be beneficial to those prone to certain
I chose for my enrich topic for this week the subject of the "Synthesis of Urea". I chose this because I like the historical aspect of scientific discoveries. I immediately learned that when you do a Google scholar search for "synthesis of urea" that you get a number of results about modern patents on synthesizing urea. It was sort of difficult to find a historical article on the synthesis or urea in the scientific journal databases. I found a couple of articles from the 1920s that talked about Friedrich Wöhler, the man credited with the first synthesis of urea, "a naturally occurring organic compound from inorganic materials." ("urea". Encyclopædia Britannica. Encyclopædia Britannica Online. Encyclopædia Britannica Inc., 2016. Web. 26 Oct.
The definition of Vitamin D deficiency is changed almost yearly, as the laboratory levels which determine what is an adequate or inadequate level of vitamin D in the blood serum are changing as well 2, 4. Recent research studies have determined that ideal levels of vitamin D are at or above 50 ng·mL-1 from 30 ng·mL-1, which was previously thought to be adequate levels within the blood. This is problematic for several reasons, but one of the most critical reasons is that the number of diseases caused at least in part by vitamin D are on the rise and
Another hormone involved in the regulation of calcium levels is calcitriol. Differently from the other two hormones discussed in this text, vitamin D, as it is also known, is a hydrophobic peptide hormone and thus acts via its nuclear receptor (VDR) in a slower, steroid-like mechanism. By activating its receptor, this hormone regulates gene promotion via nuclear response elements (VDRE). This way, vitamin D stimulates the upregulation of calcium transporters in the gastrointestinal tract, resulting in an increase in plasma calcium levels by raising the ion uptake. Moreover, it also induces a higher renal reabsorption of calcium and promotes bone resorption, increasing
D vitamins are necessary to facilitate the dietary absorption of essential minerals like phosphate, zinc or calcium. They are especially important in the metabolism of calcium. A deficiency in calcium metabolism by the body is at the base of conditions such as osteoporosis, hypocalcaemia, osteomalcia or rickets. Non-alcoholic fatty liver disease and depressive symptoms have been linked to low vitamin D. Vitamin D refers to a group of fat-soluble secosteroids. These compounds are generally synthethized by the body through skin exposure to sunlight. This mechanism is compromised by a sedentary lifestyle. Vitamin D may also be acquired through diet, but there are few dietary sources. Dietary supplementation use would be particularly useful to sedentary people and to dark-skinned people living in temperate
There is a growing interest in Vitamin D these past few years. Vitamin D is for the metabolism of the bone. It is important throughout life. Aside from that, Vitamin D have many other functions in the human body that plays an important role in the prevention of chronic diseases. Vitamin D is very important and we get enough of it from the time we are born.
A study published in Archives of Internal Medicine found that 75 percent or more of American teens and adults are deficient in Vitamin D. That is why we have so many serious illnesses, like cancer, diabetes and heart disease (Huff, 2010).
Vitamin D is a bit mystifying--the only vitamin that's also a hormone, and the only vitamin people don't have to consume from food. You manufacture it when your skin is exposed to the sun. See how you do on this quick quiz.
If a person is deficient in Vitamin D, they may have a greater chance of getting this disease. One area of key interest is that in patients who have this disease, can enhancing the uptake of Vitamin D alleviate symptoms of
Spending time in the sun causes an increase in vitamin D levels. According to the Assistant Professor at Touro University, Kim Pfotenhaur, wearing sunscreen prevents this vitamin gain. Pfotenhaur states that sunscreen “essentially nullifies the body’s ability to produce vitamin D,” (“Sunscreen…”). The article goes into further detail explaining how it is healthy to have unprotected exposure to the sun. Vitamin D is necessary for normal body functions like cell growth and proper immune functioning. A study was done that stated almost a billion people worldwide have a vitamin D deficiency due to wearing sunscreen while outside. The article recommends
* Production of Vitamin D: The sign present in the skin and UV rays, helps in the production of vitamin D, an important nutrient of the body.
Have you ever thought when you were putting on sunscreen to prevent a sunburn, you could actually be causing something much more harmful? Sunscreen has been around since 1928 in order to prevent the harsh ultraviolet-rays from the sun burning our skin and thus preventing skin cancer. In contrast, studies have shown that sunscreen has caused many people to contract skin cancer due to harsh chemicals added into the products. Sunscreen also prevents your body from absorbing Vitamin D. Mercola, the world 's #1 natural health website discusses how Dr. William Grant, a vitamin D expert scientist, found that about 30% of cancer deaths could be prevented by more vitamin D intake. That equates to 2 million people