The Effects Of Dependence On High Dosages Of Benzodiazepines

Xanax is a benzodiazepine that is most often used to treat anxiety. The effects of benzodiazepines mainly come from their ability to alter the movement of the inhibitory transmitter known as GABAa. GABA is triggered to release when it then can bind to the GABAa receptor. The binding of the two causes the ion channel to open and chloride ions are sent across the cell membrane. This causes the inhibitory factor by depolarizing the membrane (Griffin et al., 2013).

The rate of death due to prescription drug abuse in the U.S. has escalated 313 percent over the past decade. According to the Congressional Quarterly Transcription’s article "Rep. Joe Pitt Holds a Hearing on Prescription Drug Abuse," opioid prescription drugs were involved in 16,650 overdose-caused deaths in 2010, accounting for more deaths than from overdoses of heroin and cocaine. Prescribed drugs or painkillers sometimes "condemn a patient to lifelong addiction," according to Dr. Tom Frieden, director of the U.S. Centers for Disease Control and Prevention. This problem not only affects the lives of those who overdose but it affects the communities as well due to the convenience of being able to find these items in drug stores and such.

The United States currently faces an unprecedented epidemic of opioid addiction. This includes painkillers, heroin, and other drugs made from the same base chemical. In the couple of years, approximately one out of twenty Americans reported misuse or abuse of prescriptions painkillers. Heroin abuse and overdoses are on the rise and are the leading cause of injury deaths, surpassing car accidents and gun shots. The current problem differs from the opioid addiction outbreaks of the past in that it is also predominant in the middle and affluent classes. Ultimately, anyone can be fighting a battle with addiction and it is important for family members and loved ones to know the signs. The cause for this epidemic is that the current spike of opioid abuse can be traced to two decades of increased prescription rates for painkillers by well-meaning physicians.

Almost one hundred years ago, prescription drugs like morphine were available at almost any general store. Women carried bottles of very addictive potent opiate based pain killers in their purse. Many individuals like Edgar Allen Poe died from such addictions. Since that time through various federal, state and local laws, drugs like morphine are now prescription drugs; however, this has not stopped the addiction to opiate based pain killers. Today’s society combats an ever increasing number of very deadly addictive drugs from designer drugs to narcotics to the less potent but equally destructive alcohol and marijuana. With all of these new and old drugs going in and out of vogue with addicts, it appears that the increase of misuse and

Developed in 1959 by a Belgian chemist, Fentanyl came into widespread use in the mid-1990s as a painkiller and anesthetic. With the widespread availability of this drug as a common prescription, it’s not difficult to understand how easy it is to become dependant on. Here begins the problem, for once their prescriptions run out, people need to buy drugs off the street to feed their addictions. Now, buying drugs off the street can be incredibly dangerous, as drugs produced in illegal labs without a way to control dosage can be deadly. This is an especially big issue with fentanyl, because of its potency; “A few hundred

* Attention : Is it possible that you or someone you love is addicted to prescription drugs?

In the United States, 40 people die across each day due to overdosing on narcotic prescription medicine. One of the most commonly abused prescriptions is opioids painkillers such as Vicodin and codeine. Another medicine to treat anxiety and sleep aids such as Valiums and Xanax. Other abused prescriptions are stimulants to treat Attention Deficit Hyper Disorder (ADHD) like Adderall and Ritalin. When the overdose first became a problem, 60 percent of NC prescription overdose victims were dying before the arrival of emergency medical

The problem with opioids as a sole source of relief is that not only are they physically and psychologically addictive, but the user also begins to build a tolerance to the therapeutic effects. Eventually one requires higher doses in order to achieve the initial levels of pain relief. As the dose increases, so does the level of dependency and addiction. If a doctor refuses to increase the dose for the patient’s safety, the pain returns and patient may begin to feel the effects of opiate withdrawal. In worst-case scenarios people begin to abuse alcohol or seek out prescription pain medication illegally. Illicit and less expensive street drugs are often sought out if the afflicted can no longer afford their medications or cannot find a source of pain and addiction relief anywhere else. Purchase of street drugs becomes common when addiction begins to affect someone’s ability to keep a steady source of income. As a result, there has been a surge of opioid, heroin, and alcohol abuse and eventual overdose. (Dart, et al., 2015)

Concerning pharmacotherapy, physicians are reluctant to prescribe controlled medications because the DEA is more stringent. However, at CRH’s Mental Health Unit (MHU), many patients are still addicted to narcotics and stimulants. Some patients take pills to wake up, to be pain-free, and to sleep. Apparently, some doctors in the area are still prescribing these medications. They will treat obese patients with stimulants. Instead of taking the medication, patients will sell their pills to make money. Then, they come to MHU, and the hospitalist or psychiatrist will start the pharmacy-confirmed

The United States is currently under an opioid epidemic where the abuse of opioids has increased significantly within the last 20 years. It is important to understand that relapse for opioid users is common. This problem has been around for a while; studies have shown that “higher recidivism proportions were found for shorter tenure clients” (Joe, Lloyd, Simpson, & Singh, 1982). Specifically, from 2002-2007 “nonmedical use of prescription pain relievers grew from 11.0 million to 12.5 million people in the United States” (Meyer, Patel, Rattana, Quock, & Mody, 2014). This trend shows that opioid abuse is a growing issue and it requires direct action. Research has disclosed that in 2011, 2.2 million Americans were in jail/prison, and “[o]f those

We are seeing an increase in the number of people who are dying from overdoses, predominantly after abuse of prescribed opioid analgesics. This disturbing trend appears to be associated with a growing number of prescriptions in and diversion from the legal market.

Researching Xanax abuse in college-aged students, I explored the effects and consequences of this addiction. Doctors prescribed this drug for people diagnosed with severe anxiety and depression. According to RehabCenter, despite the high rate of abuse, Xanax remains the ninth best-selling drug in the United States. Young adults tend to use this drug to amplify the effects of alcohol. Circulating the streets, this drug commonly goes by “xans” or “bars”. Taking Xanax with alcohol or on their own, past users can guarantee negative effects such as severely impaired judgement. Advocating never taking this drug, I believe only a doctor’s prescription should excuse consumption.

In Australia there is a multitude of medication available to us to increase our quality of life that are typically used appropriately in the community. However, there has been a growing number of individuals misusing pharmaceutical drugs and this has now become an emerging public issue in Australia and overseas. This research will be based on the misuse of the following pharmaceutical drugs: opioids, benzodiazepines and codeine. All of which have the potential to become an addiction. The extent to which these drugs are misused by individuals will range from those intentionally using these drug for recreational reasons, to those who are unware that they are misusing the drugs due to inappropriate prescribing.

Enhance the affinity of the recognition site for GABA by inducing conformational changes that make GABA binding more efficacious.

The negative outcomes of medication misuse influence people who ill-use medicates as well as their families and companions, different organizations, and government assets (Akindipe, Abiodun, Adebajo, Lawal, & Rataemane, 2014). Albeit huge numbers of these impacts can 't be evaluated, “Office of National Drug Control Policy (ONDCP) as of late in 2002 reported that, the monetary expense of drug abuse within the United States was $180.9 billion” (Akindipe et al., 2014, Pg 250 Para 10). The