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The Effects Of Radiation On Patients With Pgc Undergoing Xrt

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Radiation is known to damage the parotid glands and surrounding tissues, resulting in various toxicities which can lead to a functional decline in swallowing. The current study examined the incidence, nature and severity of treatment-related toxicities in patients with PGC undergoing XRT and found a trend of acute toxicities and swallowing difficulties that deteriorated throughout the course of XRT and peaking at the end of the treatment. Whilst this pattern of toxicity presentation and recovery is similar to other HNC groups, the severity of toxicities presenting in this clinical group was much lower, with few patients having any persistent difficulties at 3 months post treatment. The current information can be used to develop models of …show more content…

Although the types of toxicities are comparable to prior research, there has been minimal data reported regarding the specific nature and severity of these toxicities experienced during XRT. In the current study, maximal incidence of Grade 2 severity across the toxicities monitored in this study ranged from 12-68%. This data supports that XRT induced toxicities in this clinical group were mostly mild and the majority of the patients did not require SLP intervention to manage symptoms, including dysphagia, while undergoing treatment. The low level of severe toxicities experienced by patients in our current study was similar to that found in the few studies to date which examined early toxicities following PGC management. Oliver et al. (2004) found that only 23% of their study population of 25 patients who underwent XRT experienced Grade 2 mucositis, which is directly comparable to the incidence of oral mucositis (24%) and pharyngeal mucositis (28%) in the current cohort. In comparison, Chung et al. (2011) and Patel et al. (2014) reported only 3-5% of their study population experienced Grade 2 mucositis. Chung et al. also reported low incidence of Grade 2 xerostomia (5%), while Patel et al. reported only Grade 1 xerostomia and dysgeusia in 5%. These maximal incidence rates for early toxicities are much lower than the current study data. However different rating scales (Radiation Therapy Oncology Group

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