Vaccines and Autism: Shifting Hypothesis
February 28 1998, Andrew Wakefield published research article “ Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children” in Lancet journal.
HYPOTHESIS:
There is connection of Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder with measles, mumps, and rubella vaccination in children.
NULL HYPOTHESIS:
There is no connection of Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder with measles, mumps, and rubella vaccination in children.
OUT COMES OF STUDY:
They accepted the alternative hypothesis” There is connection of Ileal-lymphoid-nodular hyperplasia, non-specific
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-“Lack of Association between Measles Virus Vaccine and Autism with Enteropathy: A Case-Control Study” published in plos one journal on September 4, 2008.
ALTERNATIVE HYPOTHESIS:
• Children with GI disturbances and autism have MV RNA in their bowl.
• There is inflammation in bowel tissues to receipt of MMR.
NULL HYPOTHESIS:
• Children with GI disturbances and autism not have MV RNA in their bowl.
• There is no inflammation in bowel tissues to receipt of MMR.
OUT COMES OF STUDY:
• They accepted the null hypothesis “Children with GI disturbances and autism not have MV RNA in their bowl” and rejected alternative hypothesis.
• They accepted the null hypothesis “There is no inflammation in bowel tissues to receipt of MMR” and rejected alternative hypothesis.
CONCLUSION:
This study gave strong confirmation against association of autism with persistent MV RNA in the GI tract or MMR exposure.
3. “No Evidence of Persisting Measles Virus in Peripheral Blood Mononuclear Cells from Children with Autism Spectrum Disorder” research article published in PEDIATRICS Volume 118, 4 October 2006. ALTERNATIVE HYPOTHESIS: Measles virus nucleic acids is present in blood of children with autism spectrum disorder.
NULL HYPOTHESIS:
No measles virus nucleic acids in blood of children with autism spectrum
Autism is not an immune-mediated disease. There is no evidence of immune activation or inflammatory lesions in people with autism. No studies have compared the incidence of autism in vaccinated, unvaccinated, or alternatively vaccinated children. Twenty epidemiologic studies have shown that neither thimerosal or MMR vaccine causes autism. There have been studies in many countries by different people who have tried multiple statistical methods. A meta-analysis of ten studies involving more than 1.2 million children reaffirms that vaccines don’t cause autism. Immunization was associated with decreased risk that children would develop autism, a possibility that’s strongest with the measles-mumps-rubella
“Based on our ongoing research of a reciprocal relationship between nervous system and immune system, we studied autism as a neuroimmune dysfunction syndrome in which auto-immunity to brain was strongly implicated. We found that autoantibodies to M[yelin] B[asic] P[rotein] were selectively present in up to 80 percent of the autistic children, but they were only rarely detected in the controls. Regarding virus serology, autistic children had a significantly higher level of measles virus antibodies as compared to controls; however, the antibody level of [the] other three viruses [assessed] did not significantly differ between the two groups. This suggested a temporal link of measles virus with autoimmunity in autism. This examination of brain auto-antibody and virus serology data revealed that there was a
In 1998, the British medical journal called The Lancet published a controversial research paper written by Andrew Wakefield. In the research paper “Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children, ” Andrew Wakefield et al. attempted to link MMR (Mumps, Measles, Rubella) vaccinations and autism. Nevertheless, the paper seemed to successfully do that. However, this was not known was at the time was Wakefield had tampered with the findings. Furthermore, this was brought to light in 2004 by British journalist Brian Deer. In 2011, thirteen years after The Lancet published the paper, and seven years after Brian Deer exposed the paper. The Lancet finally retracted the article. A common theory
In the 1998 article in the Lancet, Wakefield studied 12 children “who, after a period of apparent normality, lost acquired skills, including communication” (Wakefield, Murch, Anthony, Linnell, Casson, Malik, Berelowitz, Dhillon, Thomson, Harvey, Valentine, Davies, & Walker-Smith,1998). All 12 children were reported to show behavioral symptoms after receiving the vaccination. After receiving the vaccination, the features associated with exposure collectively included fever/delirium, rash, self-injury, repetitive behavior, loss of self-help, convulsion, gaze avoidance, diarrhea, disinterest, lack of play, vomiting, and recurrent viral pneumonia. In 8 of the 12 children, the beginning of behavioral problems was linked to the measles, mumps, and rubella vaccination by either the parents or by the child’s
For recurrent generations, there encompasses numerous controversies surrounding vaccinations for children in addition to the unfavorable reactions that may arise. The chief concerns are whether vaccinating causes serious developmental delays such as autism in children. The aim of this composition is to enlighten others that vaccinating children does not bring about autism. By means of scientific exploration along with advanced medical diagnosis in children, researchers currently recognize that the increase in autism claims are not vaccine linked.
Do vaccines cause autism is a question that has been bouncing around for over twenty years. The increase in the number of diagnosed cases of Autism Spectrum Disorder has increased significantly and due to the impact this has in people’s lives several studies have been done in an effort to determine the cause. More specifically the MMR, Measles, Mumps, and Rubella, vaccination has been accused of being the cause of autism. This accusation then contributed to families not vaccinating their children. Even though science disproves the link between vaccines and autism in several studies done in the United Kingdom, California, and Canada, many people cling to the vaccination-autism connection (Gerber, 2009).
An outbreak of the measles in the United States has sparked controversy in the autism world today. Contrary to previous theories, the measles vaccination is not a leading component to the cause of this disease. One in sixty-eight children in the United States are entering this world with Autistic Spectrum Disorder today, a thirty percent increase from the one in eighty eight
Since early 1998 autism and the MMR vaccine, a vaccine that protects the body from measles, mumps, and rubella viruses, has said to been linked. In an article written by Jeffery S. Gerber and Paul A. Offit published in Clinical Infectious Diseases, Andrew Wakefield discovered this apparent link. According to Gerber and Offit:
Wakefield published a study on the effects of the Measles, Mumps, and Rubella (MMR)-vaccine, specifically the “mercury” based and the vaccine instigating the onset of autism (Wakefield para 3). Wakefield’s study involved 12 individuals whose medical background was altered in order to support his study (Goodlee para 2). After 12 years of Wakefield’s research being published, his findings were found to be inaccurate. Many doctors and scientists alike have proven his theory wrong, causing the magazine that published the article to fully retract it (Goodlee para 2). However, the damage caused by Wakefield’s false findings has yet to be undone. The number in vaccinations dropped and the number of deadly diseases ultimately rose (Goodlee para 8). Despite study after study proving that Wakefield blatantly falsified his findings, many parents including, celebrities like Jenny McCarthy, continue to advocate against vaccinations and blame the MMR-vaccine for her child’s autism diagnosis.
In a study by Brent Taylor and his coworkers, they had studied the mystery debate link as to whether or not MMR vaccines have a link towards the development of autism. Taylor and his coworkers had examined around 498 children who were developed with autism. As Taylor examined the children, he had discovered two great findings. The first being that there was “no difference in the age of diagnosis of autism was found in vaccinated and unvaccinated children” (Taylor), and second being “symptoms of autism did not occur within 2, 4, 6 months of receiving the MMR vaccine”
There has been much research and debate on whether vaccines cause autism, however, there is no evidence that Measles, Mumps, Rubella vaccination is associated to autism. Parental age and pregnancy complications have been the most studied risk factors for ASD especially low birth weight and prematurity. Three of five studies have found low birth weight to have a significant association with autism spectrum disorder. Mothers aged 35 years and older and fathers aged 40 to 49 years have also found significant associations with autism. Pregnancy complications have been found to be significantly associated with ASD according to a 2012 systematic review. Prenatal, perinatal, and neonatal overall health have been explored by many studies. A cohort
Autism is being linked to early vaccinations to illnesses, and by doing so may cause children as their body is developing serious complications. Though the topic is still up to debate there have been numerous accounts of children obtaining autistic effects shorty after being immunized from illnesses such as the meals, mumps, and chicken pox. One such account Came Parsippany New Jersey, the parents of a 15 month year old toddler had just been to the clinic to vaccinate their child against the illness of the measles. Following the weeks after the child though fine before the vaccination in the year of 1986 started to show signs of different behavior and was having trouble communicating, by 1989 three years after his treatment he was diagnosed with autism. Now this may be just another short story to stop vaccinations but it’s backed by many of the same cases. Where autism comes from is unknown and many believe it to be a genetic defect
In 1998 a study was published by Andrew Wakefield theorizing that there was a link between autism symptoms and receiving a MMR vaccination. However, his findings are to be inconclusive considering he did not take the proper procedures to conduct a controlled study. First, he did not include control subjects in his study, so the results cannot be compared properly if there were any changes in the subjects. Second, the endoscopic or neuropsychological assessments were not done blind and the data was not collected systematically or completely. Third, the symptoms found between the children with autism and gastrointestinal problems were inconsistent. In reality, many health groups are theorizing that a vaccination does not cause autism by any
the question posed by gastroenterologist and medical researcher Andrew Wakefield and is now used as a counter-argument by those who oppose vaccination. Autism is, “A developmental brain disorder known to impair social interactions and communication,” [28]. Andrew Wakefield originally proposed a link between the measles vaccine and autism in a study he conducted and published in 1997 in the Lancet, and as a result many were led to believe the so. Actress Jenny McCarthy believed strongly that vaccines were responsible for her son's autism, “the soul left his eyes” [11]. and many have pointed out that after the wide spread of vaccines the number of autism diagnoses has
In 1963 the Noble Peace Prize winning virologist John F. Enders finally licensed his vaccine for measles. Prior to this vaccine the United States alone reported 4 million cases of the measles each year. With more scientific discoveries the measles vaccine today has evolved to include immunity against rubella and mumps along with protecting millions against illness each year. However, vaccination is a word surrounded by controversy in today’s parenting world and the Measles Mumps and Rubella vaccine (MMR) can be distinguished as possibly the most controversial vaccine of our time. Controversial because of the fear that many have that it causes autism along with other hazards. This fear has clouded